CKD 2 Flashcards
CKD: Who is at risk?
● Age (>60 years), as we age, lose 1% of kidney fxn after 35 years
● Hypertension
● Diabetes
● Family History
● Vascular disease
● Nephrotoxic drugs (NSAIDS, lithium) - ppl taking NSAIDS regularly (even OTC)
● History of AKI (prior insults)
● Multisystem diseases with potential kidney
involvement (Lupus autoimmune disease)
● Health disparity (lower income)
Symptoms of CKD
● General: fatigue, edema, decreased urine output ● Cardiac: hypertension, heart failure, pericarditis, athersclerosis ● Dermal: pruritis ● GI: anorexia, nausea/vomiting, altered taste, constipation, bleeding ● Neuromuscular: restless leg syndrome, muscle cramps, imparied cognition, peripheral neuropathy ● Malnutrition ● Bone pain (CDK mineral bone disease)
stage 1 CKD
Kidney damage with normal
or ↑ GFR
GFR ≥ 90
- see damage with ultrasound
stage 2 CKD
Kidney damage with mild
or decreased GFR
GFR 60-89
stage 3 CKD
Moderate ↓ GFR
30-59
stage 4 CKD
Severe ↓ GFR
15-29
stage 5 CKD
Kidney Failure/End Stage
Renal Disease
< 15 or dialysis
how is CKD defined?
Chronic kidney disease is defined as either kidney damage or GFR < 60 for ≥ 3 months
read
• G1–GFR> 90 ml/min/1.73m2 • G2–GFR 60-89 ml/min/1.73m2 • G3a – GFR 45-59 ml/min/1.73m2 • G3b – GFR 30-44 ml/min/1.73m2 • G4 - GFR 15-29 ml/min/1.73m2 • G5 - GFR < 15 ml/min/1.73m2 or on dialysis (5d)
Staging via Albumin:Creatinine Ratio
what are the 3 stages
A1 – ACR <3.0mg/mmol (normal – high)
• A2 – ACR 3.0-30 mg/mmol (high)
• A3 – ACR>30 mg/mmol (very high)
management of CKD
goals of therapy
● Stabilize renal function ● Delay progression to end stage renal disease ○ Dialysis ○ Transplant ● Treat/prevent complications of CKD
Lifestyle Management
increases their heart rate
● Exercise: 30-60 minutes 4-7 days per week.
● Weight loss where required
● Smoking cessation
● Adequate fluid intake
● Low sodium diet (<2000mg/day)
● Other recommendations to reduce cardiovascular risk:
○ Limit alcohol intake < 2 standard drinks per day
○ Reduce dietary protein intake 0.8-1.0 g/kg/day
Protein Restriction: 0.8-1.0g/kg/day
Too high protein can exacerbate progression of CKD
● May be recommended for adults not on dialysis :
○ Patients with >1g/day of proteinuria despite optimal BP control with an ACE inhibitor or ARB
● Avoid malnutrition
● Do not implement in patients who are < 80% IBW or with >10 g/day proteinuria
Pharmacological Management
● Glycemic control
● Blood pressure control
○ <130/80 mmHg (diabetic)
○ <120/80 mmHg (non-diabetic kidney disease)
○ Often requires multiple agents to attain target
● Avoid potentially nephrotoxic drugs
Renin Angiotensin Aldosterone System (RAAS) Inhibition:
ACE inhibitors and ARBS
drugs
which classes do we use?
Direct renin inhibitors not effectiv ein long term, adverse effects
We use ACEi and angio receptor blockers
ACEi: ● Ramipril ● Perindopril ● Lisinopril ● Enalapril ● Fosinopril ● Quinapril ARB: ● Irbesartan ● Telmisartan ● Candesartan ● Olmesartan ● Valsartan ● Eprosartan