Citric Acid Cycle Regulation Flashcards
1
Q
How is acetyl-coA regulated?
A
- pyruvate hydrogenase is inhibited if there are high concentrations of ATP, NADH, and acetyl CoA
2
Q
How is citrate synthase regulated?
A
- inhibited by high concentrations of ATP, acetyl-CoA, and NADH
- citrate can also act as an inhibitor
3
Q
How is isocitrate dehydrogenase regulated?
A
- NADH is a product of the reaction, so high levels of NADH will inhibit the reaction
- ATP also inhibits the reaction
- ADP and Ca2+ activate the reaction
4
Q
How is alpha ketoglutarate dehydrogenase regulated?
A
- Ca2+ activates it
- Succinyl CoA and NADH inhibit it
5
Q
What activates the reaction of pyruvate to acetyl CoA?
A
- Mg2+ and Ca2+
- insulin
- ADP
- pyruvate
6
Q
What inhibits the reaction of pyruvate to acetyl CoA?
A
- Acetyl-CoA
- NADH
- ATP
