CITRIC ACID CYCLE

Question 1

Pyruvate–>

Answer 1

Acetyl- CoA

Question 2

Phase 1 : condensation–>

Answer 2

enzyme: citrate synthase
acetyl CoA –> citrate
In: h2o
out: CoASH

Question 3

Phase 2: dehydration–>

Answer 3

enzyme: aconitase
citrate–> cis-aconitate
out: H2O

Question 4

Phase 2b: hydration–>

Answer 4

enzyme: aconitase
cis-aconitate–> isocitrate
in: H2O

Question 5

Phase 3: Oxidative decarboxylation

Answer 5

enzyme: isocitrate dehydrogenase
isocitrate–> alpha hetoglutarate
out: CO2 and NADH
in: NAD+

Question 6

Phase 4: Oxidative decarboxylation

Answer 6

enzyme: alpha-ketogluante dehydrogenase complex
alpha-Hetoglutarate–> succinyl-CoA
in: NAD+ and CoASH
out: NADH + CO2

Question 7

Phase 5: substrate level phosphorylation

Answer 7

enzyme: succynil-CoA synthase
succinyl-CoA–> succinate
in:GDP + Pi
out: GTP + CoASH

Question 8

Phase 6: dehydrogenation

Answer 8

enzyme: succinate dehydrogenose
succinate —> fumarate
in: FAD
out: FADH2

Question 9

phase 7: hydration

Answer 9

enzyme: fumarase
fumarate –> malate
in: H2O?
out: N/A

Question 10

Phase 8: Dehydrogenation

Answer 10

enzyme: malate dehydrogenase
malate – >oxaloacetate
in: NAD+
out: NADH