[CIS] Bleeding and Clotting [Hubbard]

Question 1

Answer 1

E. Decreased platelet numbers

***The most common cause of easy bruisability/bleeding = thrombocytopenia

[Decreased serum fibrinogen can be seen in DIC]

Question 2

Answer 2

E. Antibody interaction w/ platelet surface.

[Defective ADAMTS13 is associated with

Question 3

Answer 3

D. A platelet count of 35,000/cc.

Question 4

Answer 4

D. Immune thrombocytopenia.

*

Question 5

Answer 5

E. Observation.

Question 6

Answer 6

B. DIC

*She has abnormalities of her coagulation factors, PT and PTT are both prolonged…this implies that there is a significant issue with clotting factors.

(HELLP= hemolysis,

Question 7

Answer 7

B. Correction of the underlying problem.

Question 8

Answer 8

B. A qualitative platelet disorder.

*Not sick enough for DIC or TTP, Adenocarinoma of the uterus

Question 9

Answer 9

D. Bernard-Soulier syndrome

*Absent aggregation to ristocetin because the platelets lack the receptor

**REMEMBER: Glanzmann thrombasthenia is the opposite of bernard-soulier syndrome in their reactions to ristocetin.

Question 10

Answer 10

C. A PT of 17 seconds.

*Advanced cirrhosis; has portal hypertension

Question 11

Answer 11

B. Coagulopathy

*Remember, this patient’s liver is essentially shot,

Question 12

Answer 12

D. Fresh frozen plasma.

(*NEED TO REPLACE ALL THE CLOTTING FACTORS HE ISN”T MAKING)

(Eculizumab is used for PNH)

(Fondaparinux is a blood thinner, prolongs bleeding time)

Question 13

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Question 20

Answer 20

D. Hypercoagulability panel.

Question 21

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Question 24

Answer 24

A. In patients who are thought to be unlikely to have PE, a normal D-dimer excludes PE and no further testing is required.

Question 25

What are conditions that affect D-dimer levels?

Answer 25

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