CIS: Adrenergic Flashcards
Activation of what adrenergic receptor will increase cAMP?
Beta1-3
Drug acts directly on receptors on membrane of effector cells?
Phenylephrine
Indirect: amphetamine, cocaine, metyrosine, guanethidine
Epinephrine increases all except: A. cAMP in heart muscle B. Free fatty acids in blood C. Free glucose in blood D. Triglycerides in adipocytes
D. Epi causes free fatty acids and glycerol to release into blood
Healthy 25 y/o M on NE. BP from 115/75 to 152/100. Cell action most likely cause?
Activation of phospholipase C in arteriolar smooth muscle
- alpha1 receptor
- Gq
- phospholipase C
- IP3 and DAG
Dilation of vessels in skeletal muscle, constriction of cutaneous vessels, and direct inotropic and chronotorpic effects of heart all actions of
Epinephrine (beta2, alpha1, beta1)
37 y/o M. Spinal cord. Low dose dopamine. Effect on D1 receptors?
Increase diuresis.
Vasodilation.
High D1 density in renal, cerebral, mesenteric, and coronary
53 y/o postural hypotension. Tyramine did not increase BP, but NE caused large, transient increase BP. Degeneration where?
Postganglionic sympathetic neurons
- innervation of vascular smooth muscle
- preganglionic: ACh: nicotinic-receptor -> postganglionic: NE: alpha-receptor
When moderate pressor dose of NE given after pretreatment with large atropine, response to NE?
Increase HR by direct cardiac effect
Decrease in HR by indirect reflex (baroreflex) if without atropine
Pt with acute cardiac failure. You prefer to prescribe dobutamine but unavailable. Suitable alternative?
NE + phentolamine
B1a1 + phentolamine (blocks a1) -> beta1
What will phentolamine block? A. Bronchodilation by epi B. Vasodilation by isoproterenol C. BP increase By phenylephrine D. INcrease in cardiac contractibility by NE E. Miosis by ACh
C. Phenylephrine: alpha
-Phentolamine is alpha-blocker
A. Epi bronchial effect: B2
B. Isoprterenol: B2
D. Beta1
E. M3
Pretreatment with propranolol will block A. Phenyephrine: mydriasis B. NE: bradycardia C. Phentolamine: tachycardia D. Nicotine: vasoconstriction E. Pilocarpine: miosis
C. Phentolamine: tachycardia
Phentolamine (alpha blocker)-> decrease in BP->baroreceptors->SNS outflow->B1->tachycardia
Propranolol = beta blocker
A. Alpha1
B. Increase BP->reflex arc->muscarinic rec
D. Alpha1
E. M3
53 y/o M. 30 yr history of asthma. Hypertension. Prescribe which beta blocker? A. Isoproterenol B. Labetalol C. Metoprolol D. Propranolol E. Timolol
C. Metoprolol: cardioselective B1 blocker
A. Nonselective beta agonist
B. Alpha selective blocker
D/E. Nonselective B antagonists->trigger asthma attacks
53 y/o. Septic shock. Adrenergic drug decreases total peripheral vascular resistance at lower dose and increases it at higher dose. Drug?
Dopamine
B1 in heart
0.3: D1 in kidney->diuresis
0.7: B1 in heart->increase contractile force
1.0: alpha: increase in peripheral resistance->increase HR
47 y/o drug induced hypotension. Give phenylephrine has no change in BP. Likely overdoses drug? A. Atenelol B. Bethanecol C. Prazosin D. Propranolol E. Guaethidine
C. Prazosin: alpha1 blocker
Phenylephrine: alpha1 mimetic->increase in BP
A. B1 blocker
B. Muscarinic agonist
D. Beta blocker
E. Indirect adrenergic
What tissue will respond to catecholamine hormone in systemic circulation but not to catecholamine neurotransmitter in postganglioni sympathetic terminal? A. Ventricular myocyte B. Dilator muscle of iris C. arteriolar smooth muscle D. Bronchial smooth muscle E. Sinoatrial nodal cells in heart
D. Bronchial smooth muscle: B2
Catecholamine hormone: Epi: alpha1, beta1, beta2
Catecholamine NT: NE: alpha1, beta1
A. B1
B. a1
C. A1
E. B1
