CHX Flashcards

1
Q

Indications for CHX?

A

Cleaning dentures that have been causing denture stomatitis
Post oral/ perio surgery
Short-term use for candidiasis
Necrotising gingivitis
Aphthous ulcer
Oral mucositis in cancer patients
In physically or mentally impaired patients to help maintain good OH

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2
Q

What is CHX and its mechanism of action?

A

Antiseptic and disinfectant.
Di-cationic molecule - binds to negatively charged bacterial cell walls.
One cation invades the cell and the other alters the cell wall - increases permeability leading to precipitation of the cytoplasm and cell death

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3
Q

What is the definition of substantivity?

A

The prolonged association between a material and substrate - how long CHX sticks to oral mucosa and teeth

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4
Q

Side effects of CHX

A

Hypersensitivity
Anaphylaxis
Taste disturbances
Mucosal irritation
Staining of teeth/ composite
Burning/ stinging of the mouth if not diluted properly

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5
Q

What affects CHX substantivity?

A

Drugs
Certain food/ drinks
Absorption to oral surfaces
Maintenance of antimicrobial activity

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6
Q

What are the benefits of CHX?

A

12 hour substantivity
No known bacterial resistance or superinfection reported with use of CHX
Good safety record
Available OTC

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7
Q

What is the general prescription for CHX?

A

CHX 0.2%, 10ml swirled for 1 minute 2x/day for max. 2 weeks or until acute symptoms subside

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