Chronic renal failure

Question 1

Most important predictor factor for renal decline in glomerular disease

Answer 1

Proteinuria

Question 2

Most important cause of glomerulonephritis in ANZ

Answer 2

Ig A nephropathy

Question 3

Pathogenesis of IgA nephropathy

Answer 3

Anti-glycan Ab against galactose-deficient IgA1

Question 4

Biomarker in idiopathic membranous nephropathy

Answer 4

PLA2R Ab (Phospholipase A2 receptor Ab)

Question 5

Elevated levels of SuPAR associated with which renal condition

Answer 5

FSGS

SuPAR binds and activates podocyte beta3 integrin leading to podocyte foot process effacement

Question 6

Most common cause of NS in adults

Answer 6

Membranous nephropathy

Question 7

Induction treatment in pauci immune GN

Answer 7

IV pulse methyl pred, cyclophosphamide oral vs pulse therapy, plasma exchange, Ritux

Question 8

Indications for plasma exchange in pauci immune RPGN

Answer 8

Severe renal failure, concurrent anti-GBM antibodies, pulmonary hemorrhage

Question 9

Risk factors for AKI in CKD

Answer 9

Advanced age, female gender, cancer, heart, lung or liver disease, anemia

Question 10

Site of production of erythropoetin

Answer 10

Peritubular cells

Question 11

Risk factors for progression in membranous nephropathy

Answer 11

Male, Age>45, increased Cr at presentation