Chronic Pain Management - Exam 4 Flashcards
What is acute pain? What is the associated timeframe?
A warning of pathology, threat, or direct insult and injury to the body.
lasts from a brief moment to 6 months
What is chronic pain? What is the associated timeframe?
Persistent pain that lasts longer than the course of healing, associated with a specific injury or disease process.
after 90 days of continued pain
What is the bodies response to constant chronic versus intermittent chronic pain?
constant chronic: the body adapts in terms of normal BP, HR, RR
intermittent chronic: pain will imitate acute pain and the body does NOT adapt
How does chronic pain affect the brain?
volume of gray matter decreases
What does time to intervention have to due with success rates?
quicker you intervene with pain control the higher the rate of success and vice versus is true
What are the 2 basic neurophysiologic pain mechanisms? give a brief explanation of both
somatosensation and nociception
somatosensation: Sensory neurons activated by physical stimulus. Perception of touch, pressure, pain.
nociception: Activation of specific neural pathways due to tissue-damage and/or
potential tissue damaging stimuli.
What is the basic understanding on how pain medication works?
Drugs decrease pain by antagonizing the effect of excitatory neurotransmitters or by stimulating production/preventing breakdown of inhibitory NT’s.
______ is the first step in the pain signal. What is it? What is a nociceptor?
Nociception
The perception of a potentially tissue-damaging stimulus
Neurologic receptor capable of differentiating between noxious and innocuous stimuli
What are the 3 different types of primary afferent fibers?
A-beta
A-delta
C
Which primary afferent fiber?________ Thick myelination. Low threshold, mechanoreceptors. Fastest. Light touch, Pressure, hair movement. NOT usually pain.
A-beta
Which primary afferent fiber?________ thinly myelinated. high & low threshold mechanical & thermal receptors. The first, ‘sharp’ and ‘intense’ pain sensation.
A-delta
Which primary afferent fiber?________ Unmyelinated. Free nerve endings, High threshold to thermal, mechanical or chemical insults. 75% of all afferent fibers. Prolonged, ‘burning’ that follows the initial A-delta stimulus.
C
Where does a pain signal enter the spine cord?
pain enters at the dorsal root at the posterior portion of the spinal cord
The neurons of peripheral sensation begin in the ________. The cell body lies outside of the CNS in the _______. The nerve then enters the spinal cord via the _______.
sensory receptor
dorsal root ganglia
dorsal (posterior)root
First neuron synapse occurs at _______ (nociception from primary afferents), and _______ (A-betas, light touch)
spinal dorsal horn
dorsal column nuclei
Once in the spinal cord they make synaptic connections with ______ that may; cross the cord _______ & ascend (lateral spinothalamic tract), ascend ipsilaterally, descend, or take part in a _____
second order neurons
contralaterally
reflex arc
What is a reflex arc?
an instantaneous movement caused by the stimulus
watch youtube video on the anterolateral system!
do it!!
Where are 3rd order neurons found? What is the role?
thalamus
The thalamus processes sensory and complex motor signals; these in turn relay signals to the cortex in order to express the sensation of pain.
Also opioid receptors in ______area inhibits pain via endogenous or exogenous opiates.
periaqueductal gray
What are some major differences between white and gray matter?
What is nociceptive pain defined as?
Aberrant activation of pain sensitive afferent peripheral nerves, due to noxious stimulation of somatic or visceral structures (i.e., celiac plexus.) through activation of A delta and C fibers
What is neuropathic pain defined as? Activation of ______ by ______ increases spinal neuron sensitization which increases perception of pain.
Abnormal somatosensory processing in the PNS or CNS due to a primary lesion, neural injury or irritation, or dysfunction.like a burning, stabbing, electrical sensation
NMDA receptors
glutamate
**______ When innocuous stimuli is painful; bedsheets, air, light touch.
Allodynia
**______ Abnormal pain ‘like fire’
Dysesthesia
______ increased perception of noxious stimulation; hurts worse than it should
hyperalgesia