Chronic lymphocytic leukemia/lymphoma Flashcards
1
Q
What are the four potential etiologies?
A
Del 13- good
Trisomy 12
Del 11
Del 17- bad (p53)
2
Q
What is a HUGE complication of CLL
A
Hypogammaglobulinemia…look for recurrent infections
3
Q
Who presents with it?
A
Older men with recurrent infection
4
Q
Imunophenotype major markers
A
CD 5, Zap 70, CD 38
70, 38 bad.
5
Q
Treat with
A
Rituximab flubarabine
6
Q
Morphology
A
Smudge cells
7
Q
Chronic Lymphocytic leukemia is a disease of what cell type?
A
B cells
8
Q
What happens in CLL
A
B cells accumulate in blood, bone marrow, liver, spleen, lymph nodes as a result of increased production and prolonged lifespan with impaired apoptosis
