CHRONIC LIVER FAILURE Flashcards
1
Q
What is Chronic Liver Failure?
A
Progressive deterioration of liver function for more than 6months leading to fibrosis and cirrhosis
2
Q
What causes Chronic Liver Failure?
A
Hepatitis B, C and D Epstein Barr Virus Alcoholic Liver Disease Acetaminophen (Paracetamol) Non-Fatty Liver Disease Wilson’s Disease Primary Biliary Cholongitis
3
Q
What is Wilson’s Disease?
A
Autosomal recessive disorder leading to copper accumulation causing liver cirrhosis
4
Q
What causes non-fatty liver disease?
A
T2DM
Hypertension
Obesity
Hyperlipidaemia
5
Q
What symptoms are present in Chronic Liver Failure?
A
Nausea Anorexia Fatigue Diarrhoea Weight loss Itching
6
Q
Which signs are visible in Chronic Liver Failure?
A
Jaundice Easy bruising or bleeding Oedema Ascites Palmar Erythema Spider Naevi Gynaecomastia Hepatomegaly Splenomegaly Asterixis Nail Clubbing
7
Q
What risk factors lead to chronic liver failure?
A
Excess alcohol use Obesity Exposure to bodily fluid Sharing needles Unprotected sex with multiple partners Certain medical prescriptions
8
Q
Which investigations would you do for chronic liver failure?
A
LFT
ULTRASOUND
BIOPSY OF LIVER
9
Q
How is Chronic Liver Failure managed?
A
Treat cause
Corticosteroids
Interferon
Antivirals
Bile acids
Diuretics
N-acetyl cysteine
Surgery or Transplant
