Chronic Limb Ischaemia Flashcards

1
Q

What is chronic limb ischaemia?

A

A peripheral arterial disease resulting in the symptomatic reduction of blood supply to a limb.

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2
Q

What typically causes chronic limb ischaemia?

A

Atherosclerosis (or rarely vasculitis)

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3
Q

What are the risk factors for limb ischaemia?

A

Same as RFs for atherosclerosis:

  • Smoking
  • Diabetes mellitus
  • Hypertension
  • Hyperlipidaemia
  • Increasing age
  • Family history
  • Obesity and physical inactivity
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4
Q

How are the symptoms of chronic limb ischaemia classified?

A

Fontaine’s Classification

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5
Q

Outline Fontaine’s Classification.

A

Stage 1- Asymptomatic
Stage 2- Intermittent Claudication
Stage 3- Ischaemic Rest Pain
Stage 4- Ulceration, Gangrene or Both

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6
Q

What is intermittent claudication?

A
  • Cramping pain in the calf, thigh, or buttock
  • After walking a fixed distance (the ‘claudication distance’)
  • Relieved by rest within minutes.
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7
Q

What is Buerger’s Test?

A
  • Test for severe ischaemia
  • Lye the patient supine and raising their legs until they go pale and then lower them until the colour returns (or even until hyperaemic)
  • The angle at which a limb goes pale is Buerger’s angle
  • An angle of less than 20 deg. is severe ischaemia
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8
Q

What is Leriche Syndrome?

A
  • Peripheral arterial disease of the aortic bifurcation

- Presents as buttock/thigh pain and erectile dysfunction

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9
Q

What is critical limb ischaemia?

A

Advanced form of chronic limb ischaemia

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10
Q

How is critical limb ischaemia defined?

A
  • ABPI less than 0.5
  • Presence of ischaemic lesions of gangrene
  • Ischaemic pain on rest for 2+ weeks requiring opiate analgesia
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11
Q

What is an ABPI?

A

A measure of BP in the upper and lower limb, allowing them to be compared

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12
Q

How is ABPI calculated?

A

Ankle BP/Brachial BP

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13
Q

How would an ischaemic limb typically look/feel?

A
  • Cold
  • Pale
  • Weak/absent pulses
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14
Q

How is ABPI used to classify ischaemia severity?

A

Normal 0.9+
Mild<0.9
Moderate<0.8
Severe<0.5

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15
Q

What could an ABPI of 1.2+ mean

A

Interpret with caution, artery calcification can also cause a falsely high ABPI

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16
Q

What imaging should be used for critical limb ischaemia?

A
  • Doppler USS

- CT angiography

17
Q

How should a CVS risk assessment be done?

A
  • ECG
  • Bloods (lipid profile)
  • Cap glucose
  • BP
18
Q

How is critical limb ischaemia surgically managed?

A
  • Angioplasty (+- stenting) or Bypass

- Amputation (if gangrenous/septic, or if patient isn’t suitable for angio/bypass)

19
Q

When is surgery offered?

A

When risk factor reduction and supervised exercise aren’t reducing symptoms

20
Q

What medical management is used in critical lib ischaemia?

A
  • Lifestyle advice (smoking cessation, regular exercise, weight reduction, supervised exercise)
  • Statin therapy (ideally atorvastatin 80mg OD)
  • Anti-platelet therapy (ideally clopidogrel 75mg OD)
  • Optimise diabetes control
21
Q

What complications may occur in chronic limb ischaemia?

A
  • Sepsis/infection
  • Ulceration
  • Reduced mobility and QoL
  • Acute-on-chronic Limb ischaemia
22
Q

What is the mortality rate in critical limb ischaemia?

A

50% at 5 years