Chronic kidney disease Flashcards
Stags of CKD based on eGFR
With added proteinuria/abluminurea = worse outcome
None/mild/Heavy (A1-A3)
Definition of chronic kidney disease
Must have kidney damage or eGFR <60 for greater than three months
Causes of CKD
Glad shop
Chronic glomerulonpehritis - 20%, Chronic refluxnephropathy -15%
Lupus
Analgesiacs
DM - 20% Most common recognised cause
Systemic vascular disease
Hypertesion
Obstruction
Polycystic kidney disease
Renovascular (including hypertension - 15%
Screening
Intervening early in CKD can reduce the progression to ESRF and so screening is recommended for at risk patients with:
- DM
- hypertension
- CV disease
- structural renal disease
- recurrent UTS or childhood history of Vesicoureteric reflux
- family history of ESRF
History in known/suspected CKD
-
Possible cause -
- Ask about previous UTI, LUTS
- PMH of increased BP, DM, IHD
- check drug history and family history
- systemic review: malignancy>
-
Current state:
- Uraemic symptoms such as anorexia, vomitting, restless legs, fatigue, weakness, pruritis, bone pain
- in women ask about ammeonorhoea and impotence in men
Examination in patient with suspected or known CKD
Look for
- cause of ESRF/CKD e.g polycystic kineys, signs of IHD, DM
- current mode of renal replacement therapy and any complications
- previous types of RRT and any compliations
Periphery- hypertension, ateriovenous fistula, signs of previous transplant- bruising from steroids, skin malignancy
Face- pallor of anaemia, yellow tinge of uraemia, gum hypertrophy from cicilosporin, cushingoid appearance
neck- current or previous tunnelled line inserstion , scar from parathyroidectomy
Abdomen: PD catheter or previous catheter (small midline scar just below umbilicus and small rund scar to sife of midline from exit site), signs of previous transplant (hockey-tick scar, palpable mass), ballotable polycystic kidneys
Elsewhere: signs of diabetic nephropahty, retinopathy, cardiovascular or periphieral vascular disease
Symptoms
Rare in the early stages of disease
usually only occur once stage 4 is reached
Late stage disease
- fatigue
- metallic tase
- restless legs
- low urine output
- anorexia - loss of apetite
- shortness of breath pulmonary odema
- ankle swelling - fluid overload
- confusion - severe uraemia
Signs
- increased BP- fluid overload + release of vasoactive hormones
- oedema- peripheral and pulmonary
- pallor/yellow skin pigmentaiton - increased blood urea
- exoriations- pruritis
- pericardial rub- pericarditis
- tachypnea- metabolic acidois
- tetany- hyperphosphataemia
- coma- severe uraemia
What worses with each stage of CKD
Cardiovascular risk factors and should be adressed even in teh early stages
Management of chronic renal failure
Blood pressure control (aim for <130/80mmhg)
- ACE i
- other hypertensives
- diuretics
Reduction in proteinuria- ACE i
Treatment of anaemia
- IV iron
- erythropoetin
Diet
- low salt intake
- low potassium intake
- high calorie intake
Treatment of hyperphosphataemia and hypocalcaemia (renal bone disease)
- phosphate binders
- alpha caclidol
glucose control in diabetes
Hyperlipidaemia control
Volume status monitoring
Avoid nephrotoxic drugs
Clinical presentation of chronic renal failure
RESIN and 8 Ps
Retinopathy
E exoriations (scatch marks)
S skin is yellow
i increased blood pressure
N nails are brown
Pallor,
purpura and brusing
pericarditis
pleural effusions
pulmonary oedema
peripheral oedema
proximal myopathy
peripheral neuropathy
Salt Losing vs Salt retaining
Investigations
Bloods
- ↓Hb – normochromic & normocytic – ↓Epo
- ↑Urea & ↑Creatinine
- ↓ Calcium & ↑Phosphate
- ↑Parathyroid Hormone– due to low Calcium
- increased alk phos (renal osteodystrophy)
Urine
- Microscopy, Culture & Sensitivity
- Dipstick – proteinurea, haematuria
- 24 Hour Urinary Protein
Imaging
- Renal ultrasound – exclude obstruction, assess kidney size (small in CRF)
- CXR – Cardiomegaly, Pleural or Pericardial effusions, Pulmonary Oedema
- Renal biopsy – if cause is unclear & kidneys are normal size
Anti-proteinuric action of ACE inhibitors
- Reduction of systemic blood pressure
- Relaxation of efferent arteriole from glomerulus (so additional reduction of intraglomerular pressure)
- Gradual reduction in glomerular permeability to protein ?cause
Response of kidneys to blood pressure
Hypotensive
- kidneys respond by releasing renin (activating RAS), leading to release of angiotensin II which causes contriction of the efferent arteriole
- Also causes release of prostaglandins to dilate the afferent arteriole
- ultimately maintaining pressure