Chronic Kidney Disease Flashcards

1
Q

What GFR range is classified as stage 1

A

mor or equal than 90

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2
Q

What stage of CKD is GFR range of 60-89

A

2

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3
Q

what stage of CKD is GFR rate of 30-59

A

3

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4
Q

what stage of CKD is GFR of 15-29

A

4

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5
Q

what stage of ckd is GFR <15

A

5

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6
Q

what stage of CKD is classified as renal failure

A

stage 5

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7
Q

what stage of CKD would you prepare for renal replacement therapy

A

4

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8
Q

what is the definition of CKD

A

either functional or structural
kidney damage or a glomerular filtration
rate (GFR) less than 60 mL/min per
1.73m2
for at least 3 months

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9
Q

3 MAIN causes of CKD

A

type 2 DM, HPT, HIV

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10
Q

What medication is causing ckd

A

PPI (proton pump inhibitor)

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11
Q

how long after diabetes diagnosis are patients at risk of getting diabetic nepropathy

A

15-25 yrs

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12
Q

Are kidneys in diabetic patients hyper/hypofiltrating

A

hyper

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13
Q

what feature does some HIV patients with CKD get

A

proteinuria (around 5%)

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14
Q

what is the primary prevention of CKD

A

healthy lifestyles in terms of Obesity, smoking, hpt. Educational programmes also help

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15
Q

How do you implement/promote healthy lifestyles

A

healthy eating in school, compulsory sport, anti-smoking campaigns, PREVENT HIV

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16
Q

What should be done at a community health care centre for early detection

A

Routine BP checks, glucose checks for tho those at risk for DM, voluntary HIV testing

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17
Q

what is the goal BP for patients + DM patients to reduce risk

A

Normal patients: <140/90, DM <130/80

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18
Q

what should the HBA1C% be

19
Q

what should the fasting glucose be in screening tests

20
Q

when should statin therapy be considered when screening

A

if LDL is more than 3 mmol/L or total cholesterol>5mmol/L

21
Q

what patient profiles should have dipsticks as screening tests and how often

A

diabetics, hpt, HIV+, >65. They should have it anually

22
Q

what test should diabetics with negative proteinuria test on dipsticks have

A

spot urine test for microalbuminuria

23
Q

what 2 characteristics are needed to classify CKD

A

GFR<60 and/or overt proteinuria/haematuria

24
Q

what characteristic do diabetics need on spot urine test to be in early CKD

A

microalbuminuria

25
what spot urine result is classified as microalbuminuria?
ratio between 3-30
26
what spot urine ratio is classified as macroalbuminuria
>30
27
Where is CKD-EPI more accurate in staging CKD
stages 4/5
28
why is CKD-EPI/ MDRD more convenient?
no need for patient weight
29
what staging system is better at normal GFR?
cockcroft-gault equation
30
How can you slow progression in CKD stage 1/2
Treat the primary causes of CKD: Treat BP: <130/80 Treat proteinuria: <1g/day by using ACE-I/ARB Treat hyperlipidaemia: LDL<3mmol/l or less if having IHD Treat Glucose: HBA1C <7% but not less than 6.5% Lifestyle modifications: nutritional diet, stopping smoking, exercise
31
How should you slow progression at stage 3
Limit increase in phosphate/PTH by: - low phosphate diet - phosphate binders - Vitamin D - Calcimimetics
32
slowing progression of stage 4/5
treat anaemia: - exclude iron def anaemia by looking for ferritin <100/transferrin sats <20% erythropoeisis stimulating agents keeping Hb between 10-12 If bicarbonate <20mmol/L it must be treated with NaBic
33
why is bicarbonate supplementation beneficiary
slows rate of progression + improves nutrtional status
34
what is latest that you should refer CKD to nephrologist
stage 4
35
what are the 3 options included in renal replacement therapy
hemodialysis peritoneal dialysis transplantation
36
how often should haemodialysis be done?
4 hours 3x weekly/ Nocturnal for 6-8hrs
37
Is peritoneal dialysis continuous of intermittent
continuous
38
when do they take a kidney from a deceased donor
after brain death, after circulatory
39
Which formulas are no longer used to calculate eGFR?
Cockcroft-Gault
40
Patients should be referred to a nephrologist once the eGFR drops below:
30ml/min
41
Iron supplementation in CKD is targeted to Ferritin levels in the following range:
200 - 500ug/L
42
What is the MOST COMMON form of anaemia seen in patients with CKD?
Normocytic normochromic anaemia
43
Which phosphate binders are no longer much used because of safety concerns?
Aluminium Hydroxide
44
The best form of renal replacement therapy is:
Kidney Transplantation