Chronic Disease Stations Flashcards
What is bilirubin?
Breakdown product of RBC
Name 5 factors that can cause a rise in bilirubin
Gilbert’s syndrome
Stress
Fasting
Drugs
Haemolytic disease
What is Gilbert’s syndrome?
Inherited disease where liver can’t process bilirubin properly = raised bilirubin levels on testing + episodes of jaundice
Name 3 drugs that can increase bilirubin levels
Rifampicin
Sulfonamide Abx
Carbimazole (thyroid meds)
What is ALT?
Alanine transaminase - marker of liver cell damage
What is a high ALT?
> 120 IU/L
Name 4 hepatic causes of raised ALT
Alcohol
Viral hepatitis
Drugs
Wilson’s disease
Name 4 drugs that can increase ALT levels
NSAIDs
Abx
Statins
Anti-epileptics
Name 4 non-hepatic causes of raised ALT
Coeliac disease
Strenuous exercise
Muscle disease
Hypo/hyperthyroidism
What is AST?
Aspartate aminotransferase
What does an AST:ALT >2.1 indicate?
Alcohol related liver disease
What does an AST:ALT <2.1 indicate?
Hepatic steatosis/chronic viral hepatitis
What is ALP?
Alkaline phosphatase
Name 2 physiological causes of raised ALP
3rd trimester pregnancy
Bone growth in adolescents
Name 4 pathological causes of raised ALP
Heart failure
Bone diseases
Steroids
Bile duct obstruction/pathology
What is gammaGT used for?
Sensitive but non-specific marker for hepatobiliary disease
Name 7 causes of raised gamma GT
Hepatobiliary disease
Pancreatic disease
Alcoholism
COPD
Diabetes
MI
DRugs e.g. OCP, carbamazepine (anti-epileptic)
Name 5 causes of low albumin
Liver disease
Malnutrition/absorption
Pregnancy
Injury/infection
Chronic illness-increased catabolism
Name 4 conditions that can increase HbA1c levels
Iron deficiency
Alcoholism
Chronic renal failure
Splenectomy
Name 3 conditions that can decrease HbA1c levels
Chronic liver disease
Haemoglobinopathies
RA
Name 3 drugs/vitamins that can decrease HbA1c levels
Vit C
Vit E
Aspirin
Ribavirin (anti-viral for hepatitis)
What advice would you give to someone with raised HbA1c levels?
High fibre, low sugar diet
Less saturated fats
Exercise + physical activity
Reduce alcohol + smoking
Attend yearly check ups e.g. urinalysis, eye tests, diabetic foot screenings
What is INR?
International Normalised Ratio - measure of how thick/thin blood is - how well it clots
What symptoms should you ask about for raised INR?
Bruising
Bleeding-gums, heavy periods, nosebleeds etc
Blood in stool/urine
Sudden severe back pain-spontaneous retroperitoneal bleeding
What symptoms should you ask about for decreased INR?
Stroke symptoms
Visual changes
DVT/PE symptoms-pain, red, swollen, chest pain, SOB
Name 4 contraindications for warfarin
Pregnancy
Hemorrhagic stroke
Within 72hrs major surgery
Severe hepatic impairment (processed by liver)