Chronic disease management Flashcards
What does INR stand for, and what information does it provide?
International Normalised Ratio (of prothrombin time). It provides information about a person’s blood’s tendency to clot
What should normal INR be, an what is the INR target range for a patient taking warfarin?
Normal: 1
Taking warfarin: 2 - 3
Name 5 foods that are high in Vitamin K
Broccoli, kale, green apples, cucumber, celery, pears, avocado (plus other green fruit and veg)
Explain (simply) the mechanism of action for warfarin
It is an anticoagulant - this decreases the bodies ability to form blood clots. It blocks an enzyme that stops the production of some clotting factors (specifically II, VII, IX and X)
Give 5 symptoms of a high INR (ie. symptoms of the complications of a prolonged clotting time)
Unusual/severe headache, increased bruising, prolonged bleeding after minor cuts, prolonged menstrual bleeding, bleeding from gums, haematemesis/haematuria/blood in stools
Give 5 factors (other than medication) that increase the risk of an elevated INR
DISEASE, DOSE, DRUGS, DIET Liver failure (bc lack of clotting factors), alcohol, bleeding disorders, decrease in vitamin K intake, smoking
How can changing warfarin adherence increase the risk of elevated INR?
DISEASE, DOSE, DRUGS, DIET
Taking too much warfarin (e.g double dosing), using warfarin and heparin together (which is fine, but INR needs to be checked more regularly)
Give 3 examples of medications that, in combination with warfarin, increase the risk of an elevated INR
Aspirin, NSAIDs, St Johns wart (herbal medication), Omeprazole, Metronidazole
Give 3 examples of lifestyle changes that can be made to decrease a person’s risk of bleeding
Avoid activities that may cause bleeding or bruising
Brush and shave gently
Tell your dentist and other healthcare professionals if you take anticoagulation
Give 5 symptoms of a low INR (ie. symptoms of a reduced clotting time)
Stroke symptoms: weakness in a limb, speech changes, visual changes, numbness/tingling
DVT/PE symptoms: new pain/swelling/redness/heat in a body part, new SOB or chest pain
Give 3 factors (other than warfarin adherence) that increase the risk of a low INR
Supplements containing vitamin K, high intake of foods containing vitamin K, oestrogen containing medication (e.g. OCP and HRT)
How is an elevated INR treated?
Vitamin K
Blood components
If there isn’t a clear explanation, warfarin dose may be decreased and INR re-checked in 4-7 days
How is a low INR treated?
LMWH, Warfarin
Name 4 conditions in which warfarin may be prescribed
Stroke, MI, DVT/PE, Atrial Fibrillation, Thrombophilia
What are the rules regarding taking warfarin and going on holiday?
Arrange for your INR to be checked before you go away. If you’re away for longer than a month, you may need your INR checking while you’re away. Make sure you have enough medication to last the duration of your trip