Chromosome Structure

Question 1

C value

Answer 1

total amount of DNA in the haploid genome

Question 2

correlation between _

Answer 2

species complexity and number of genes

Question 3

no correlation between _

Answer 3

species complexity and total genome size/chromosome number

Question 4

structural elements of chromosome

Answer 4

two telomeres, centromere, and origins of replication

Question 5

centromeres

Answer 5

contain alpha satellite DNA; needed for attachment to mitotic spindle and chromosome segregation

Question 6

CENP-A

Answer 6

key component of centromeres

Question 7

centromeres require

Answer 7

CENP-A and secondary structure/higher order DNA structure

Question 8

centromeres do not require _

Answer 8

specific DNA sequence

Question 9

LINE elements

Answer 9

encode proteins needed for retrotransposition - reverse transcriptase and endonuclease activities

Question 10

SINE elements

Answer 10

rely on LINE elements for transposition

Question 11

hemophilia A

Answer 11

L1 insertion into gene encoding protein factor VIII (one of proteins needed to form blood clots is missing or reduced)

Question 12

colon cancer

Answer 12

insertion of L1 into APC gene