Chromosomal factors and recurrent miscarriage

Question 1

% rec miscarriages due to parental chromosomes

Answer 1

• 2 - 5 %

- Balanced reciprocal or Robertsonian translocation

Question 2

% rec miscarriages and fetal chromosmal abnormalities

Answer 2

30–57% of subsequent miscarriages

Question 3

Parents of balanced translocation should be informed that

Answer 3

• They have a higher (50–70%) chance of a healthy live birth in future untreated pregnancies following
  natural conception than is currently achieved after preimplantation genetic diagnosis/in vitro fertilisation (approximately 30%)

Question 4

% miscarriages due to sporadic chromosomal abnormalities

Answer 4

70 %