Cholinomimetic Drugs Flashcards
Name direct agonists
Bethanochol
Carbachol
Methacoline
Pilocarpine
Moa of bethanochol
Causes bladder contraction
Use of bethanochol
Used in neurogenic bladder
Moa of carbochol
Constricts pupil
Use of carbachol
Used in acute angle glaucoma to relive intraocular pressure
Pilocarpine MOA
Contraction of ciliary muscles and constriction of pupil
Can cross the blood brain barrier
Uses of pilocarpine
Used in acute angle and open angle glaucoma
It increases sweat saliva and tears
Used to test in CF and Xerostomia and sjogrens
Moa of methacolline
Activatesmuscaranic receptors in bronchi
Methacoline used in
Challenge test for asthma
Can all direct agonist be broken down by AchE
No
Name indirect agonist
Donpezil
Rivastigmine
Neostigmine
Pyridostigmine
Physostigmine
Drugs used in Alzheimer’s
Donapezil
Rivastigmine
Drug used in myasthenia graves diagnosis
Edrophonium
Uses of neostigmine
Used in postoperative neurogenic ileus
Bladder retention and myasthenia gravis
Uses of pyridostigmine
Used in myasthenia gravis ( long acting )
Used along with glycopyrrolate or propanthaline to control pyridostigmine adverse effects
Physostigmine uses
Physostigmine also used in myasthenia gravis
Used as an antidote in anti cholinergic toxicity
It can cross the blood brain barrier
How to indirect cholinomimetics act
They inhibit AchE
Anticholinesterase poisoning or cholinergic poisoning
Muscaranic effects
Diarrhea
Urination
Mitosis
Bradycardia
Emetics
Lacrimation
Sweating
Salivation
Cholinergic poisoning nicotinic effects
Neuromuscular blockade
CNS effects of organophosphate poisoning
Respiratory depression
Lethargy
Muscaranic effects of OP poisoning treatment
Atropine
It’s a competitive inhibitor
Can cross BBB so can relive CNS symptoms
Nicotinic effects of OP poisoning treatment
Pralidoxime
It regenerates AchE
Does not cross BBB
