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Ans Drugs > Cholinomimetic Drugs > Flashcards

Cholinomimetic Drugs Flashcards

1
Q

Name direct agonists

A

Bethanochol
Carbachol
Methacoline
Pilocarpine

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2
Q

Moa of bethanochol

A

Causes bladder contraction

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3
Q

Use of bethanochol

A

Used in neurogenic bladder

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4
Q

Moa of carbochol

A

Constricts pupil

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5
Q

Use of carbachol

A

Used in acute angle glaucoma to relive intraocular pressure

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6
Q

Pilocarpine MOA

A

Contraction of ciliary muscles and constriction of pupil
Can cross the blood brain barrier

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7
Q

Uses of pilocarpine

A

Used in acute angle and open angle glaucoma
It increases sweat saliva and tears
Used to test in CF and Xerostomia and sjogrens

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8
Q

Moa of methacolline

A

Activatesmuscaranic receptors in bronchi

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9
Q

Methacoline used in

A

Challenge test for asthma

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10
Q

Can all direct agonist be broken down by AchE

A

No

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11
Q

Name indirect agonist

A

Donpezil
Rivastigmine
Neostigmine
Pyridostigmine
Physostigmine

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12
Q

Drugs used in Alzheimer’s

A

Donapezil
Rivastigmine

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13
Q

Drug used in myasthenia graves diagnosis

A

Edrophonium

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14
Q

Uses of neostigmine

A

Used in postoperative neurogenic ileus
Bladder retention and myasthenia gravis

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15
Q

Uses of pyridostigmine

A

Used in myasthenia gravis ( long acting )
Used along with glycopyrrolate or propanthaline to control pyridostigmine adverse effects

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16
Q

Physostigmine uses

A

Physostigmine also used in myasthenia gravis
Used as an antidote in anti cholinergic toxicity
It can cross the blood brain barrier

17
Q

How to indirect cholinomimetics act

A

They inhibit AchE

18
Q

Anticholinesterase poisoning or cholinergic poisoning
Muscaranic effects

A

Diarrhea
Urination
Mitosis
Bradycardia
Emetics
Lacrimation
Sweating
Salivation

19
Q

Cholinergic poisoning nicotinic effects

A

Neuromuscular blockade

20
Q

CNS effects of organophosphate poisoning

A

Respiratory depression
Lethargy

21
Q

Muscaranic effects of OP poisoning treatment

A

Atropine
It’s a competitive inhibitor
Can cross BBB so can relive CNS symptoms

22
Q

Nicotinic effects of OP poisoning treatment

A

Pralidoxime
It regenerates AchE
Does not cross BBB

Ans Drugs (3 decks)

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