Cholinesterase inhibitors Flashcards
Cholinesterase inhibitors have effects on what?
skeletal mm, autonomic system, brain
Ach action on what receptors is enhanced by cholinesterase inhibitors?
muscarinic and nicotinic
two main binding sites on cholinesterase enzyme that are important for drug action
anionic, esteratic
Anionic site of the enzyme will be blocked where
Tyrosine and Phenylalanine ring system
Esteratic sit of teh enzyme will be blocked where?
Ser, His, Glu hydrolyses ester
Achase inhibitors are used to do what?
increase GI activity post-op
Achase inhibitor is what type structure? how to take?
quaternary, PO just give a bit of a larger dose
Achase inhibitors are more popular than one drug?
bethanacol (muscarinic PSymimetic)
myasthenia gravis
autoimmune disease against nicotinic receptors
treatment begins when you lose how many of your receptors
2/3 receptors
incidence of MG/ more common in who
1/10,000, women
how to diagnose MG
edrophonium
treatment for MG
pyridostigmine po
how to ddx between myasthenic crisis versus cholinergic crisis
give edrophonium- if MG, will improve for a few minutes (short duration drug), if cholinergic, worsen.
