Cholinergic Receptors and Signaling Flashcards
What is the receptor class of M1 receptors?
What are the major associated signaling components?
GPCR (Gq)
increased PLC and PKC activity
increased conversion of PIP2 into IP3/DAG
increased [Ca2+]
What is the receptor class of M2 receptors?
What are the major associated signaling components?
GPCR (Gi)
decreased adenylyl cylase and PKA activity
decreased [cAMP]
What is the receptor class of M3 receptors?
What are the major associated signaling components?
GPCR (Gq)
increased PLC and PKC activity
increased conversion of PIP2 into IP3/DAG
increased [Ca2+]
What is the receptor class of M4 receptors?
What are the major associated signaling components?
GPCR (Gi)
decreased adenylyl cylase and PKA activity
decreased [cAMP]
What is the receptor class of M5 receptors?
What are the major associated signaling components?
GPCR (Gq)
increased PLC and PKC activity
increased conversion of PIP2 into IP3/DAG
increased [Ca2+]
What is the receptor class of nicotinic receptors?
What are the major associated signaling components?
Na+/K+ channel
Where are M1 receptors found?
-nerves
Where are M2 receptors found?
- heart
- smooth muscle
Where are M3 receptors found?
- glandular tissue
- smooth muscle
- endothelium
*most common muscarinic receptor
Where are M4 receptors found?
CNS
Where are M5 receptors found?
CNS
Where are nicotinic receptors found?
- sympathetic/parasympathetic postganglionic cell bodies
- CNS
- skeletal muscle, neuromuscular junctions
- adrenal medulla
What are the major effects of mAChR stimulation?
Eye:
- pupillary contraction (miosis)
- ciliary muscle contractioin (near vision)
Heart:
-decreased rate and force of contraction
Lungs:
-bonchoconstriction
GI:
- increased motility and secretion
- increased salivation
GU:
-aides urination
What are the major effects of nAChR stimulation?
- nerve deploarization
- skeletal muscle end plate depolarization
