Cholinergic Receptor-Inhibitors

Question 1

Atropine

Answer 1

Tertiary amine antimuscarinic. Blocks muscarinic receptors. Mydriasis; cycloplegia. General block of muscarinic functions

Question 2

Scopolamine

Answer 2

Tertiary amine antimuscarinic. Blocks muscarinic receptors. Prevent or reduce motion sickness. General block of muscarinic functions

Question 3

Dicyclomine

Answer 3

Tertiary amine antimuscarinic. Blocks muscarinic receptors. Reduce transient hypermotility. General block of muscarinic functions

Question 4

Tropicamide

Answer 4

Tertiary amine antimuscarinic. Blocks muscarinic receptors. Mydriasis; cycloplegia. General block of muscarinic functions. very rapidly metabolized.

Question 5

Tolterodine

Answer 5

Tertiary amine antimuscarinic. Blocks muscarinic receptors. Treat transient cystitis; postoperative bladder spasms; incontinence. General block of muscarinic functions

Question 6

Benzotropine

Answer 6

Tertiary amine antimuscarinic. Blocks muscarinic receptors. Treat manifestations of Parkinson’s disease. General block of muscarinic functions. Crosses BBB

Question 7

Ipratropium

Answer 7

Quarternary amine antimuscarinic. Blocks muscarinic receptors. Bronchodilation in asthma or COPD General block of muscarinic functions

Question 8

Tiotropium

Answer 8

Quarternary amine antimuscarinic. Blocks muscarinic receptors. Bronchodilation in asthma or COPD. General block of muscarinic functions. Longer acting than Ipratropium.

Question 9

Hexamethonium

Answer 9

Ganglionic blocker. Blocks ganglionic (Nn) receptor. Treats hypertensive crisis; “Bloodless” field surgery. Rarely used.

Question 10

Succinylcholine

Answer 10

Depolarizing blocker. Overstim of nicotinic receptor, leading to desensitization of muscle unit to further ACh stim. Brief procedures (trach intubation, reset dislocated joints). SE: Respiratory paralysis; disturbance of autonomic function. Produces flaccid paralysis w/i 1 min

Question 11

Tubocurarine

Answer 11

Nondepolarizing blocker Blocks nicotinic (Nm) receptor. Muscle relaxant for surgery w/o deep anesthesia. SE: Respiratory paralysis; disturbance of autonomic function. Lasts 30-60 min

Question 12

Mivacurium

Answer 12

Nondepolarizing blocker Blocks nicotinic (Nm) receptor. Muscle relaxant for surgery w/o deep anesthesia. SE: Respiratory paralysis; disturbance of autonomic function. Rapidly hydrolyzed, short acting.

Question 13

Botulinum Toxin A

Answer 13

Local paralytic. Blocks vesicle fusion and ACh release on presynaptic terminal by degrading SNAP-25. Reduce frown lines and wrinkles; achalasia; strabismus; oromandibular dystonia