Cholinergic Drugs Flashcards
Cholingeric Agents are AKA…?
- Parasympatholytics
- Cholinergic Agonists
stimulate/mimic PANS
Be able to write out the chart regarding cholinergic agonists
notes
What are the Trade names (2) for bethanechol?
- Duvoid
- Urecholine
Describe: 💊bethanechol
Type, Direct/Indirect, MOA, Route, Indications,Therapeutic Effects, Side Effects, Contraindications, Nursing Implications (Assess, Check/Monitor)
Type
- Muscarinic Agonist
Direct/Indirect
- Direct
MOA
- Binds to cholinergic (muscarinic) receptor → ↑ muscle contractions (GI & GU tract) → ↑ smooth muscle tone & (digestive + urinary) contractions
Route
- IV/IM
Indications
- Urinary retention (post op, nonobstructive)
Therapeutic Effects
- Promote bladder emptying
-> ↑ Urination - ↑ GI motility
Side Effects
- ↑ abdominal cramping
- Hypotension
-> fainting - ↑ salivation & sweating
Contraindications
- Asthma
- Bradycardia
- Parkinsons
- Hyperthyroidism
Nursing Implications
Assess:
- Urine elimination b4 administration (baseline)
Check/Monitor:
- Voiding pattern
- Urinary retention after voiding
What is the Trade name for donepezil
Aricept
Describe: donepezil
Type, Direct/Indirect, MOA, Route, Indications,Therapeutic Effects, Side Effects, Contraindications, Nursing Implications (Monitor, Schedule)
Type
- Cholinesterase Inhibitors
- Anti-cholinesterase Agents
Direct/Indirect
- Indirect
MOA
- Inhibit AChE (enz that destroys ACh) → pvt breakdown of ACh → ↑ [ACh]
Route
- IV/IM
Indications
- Alzheimer DZ
Therapeutic Effects
- Reversal of life threatening delirium
- Reversal of anticholinergic toxicity
Side Effects
- ↑ Salivation
- ↑ GI motility
-> Aaspe (discomfort) - Pupil constriction
- Mucus
- Wet cough
Contraindications
- Asthma
- Bradycardia
-> Cardiovascular DZ - Diabetes
Nursing Implications
Monitor:
- Muscle strength/weakness
neuromuscular status - Ptosis (drooping of upper eyelid)
- Diplopia (double vision)
- Chewing
Schedule:
- Medication around mealtimes
- Activities to avoid fatigue
What is the Trade name for neostigmine ?
Prostigmin
Describe: 💊neostigmine
Type, Direct/Indirect, MOA, Route, Indications,Therapeutic Effects, Side Effects, Contraindications, Nursing Implications (Monitor, Schedule)
Type
- Cholinesterase Inhibitors
- Anti-cholinesterase Agents
Direct/Indirect
- Indirect
MOA
- Inhibit AChE (enz that destroys ACh) → pvt breakdown of ACh → ↑ [ACh]
Route
- IV/IM
Indications
*Myasthenia Gravis
Therapeutic Effects
- Reversal of life threatening delirium
- Reversal of anticholinergic toxicity
Side Effects
- ↑ Salivation
- ↑GI motility
-> Aaspe (discomfort) - Pupil constriction
- Mucus
- Wet cough
Contraindications
- Asthma
- Bradycardia
-> Cardiovascular DZ - Diabetes
Nursing Implications
Monitor:
- Muscle strength/weakness
neuromuscular status - Ptosis (drooping of upper eyelid)
- Diplopia (double vision)
- Chewing
Schedule:
- Medication around mealtimes
- Activities to avoid fatigue
