Cholinergic Drugs

Question 1

Metoclopramide hydrochloride (ROA and Uses, Considerations)

DAC

Answer 1

IM and IV

GERD, gastroparesis, nausea and vomiting

Causes drowsiness, dizziness, fatigue, restlessness, headache, nausea, vomiting

Question 2

Bethanechol chloride

Answer 2

PO and SUBQ

Urinary retention and neurogenic bladder

Nausea, vomiting, diarrhea, abdominal cramps, hypersalivation, diaphoresis, headache, dizziness, flushing, urinary urgency, miosis, lacrimation

Question 3

Edrophonium chloride (ROA and Uses, Considerations)

Answer 3

IV and IM

To diagnose Myasthenia Gravis, neuromuscular blockade reversal

Monitor PR, RR, BP, neurologic static and ECG

May cause:
Diplopia (Double vision)
Hypersalivation
Dysphonia (verbal difficulty)
Dysphagia (difficulty swallowing)
Dysarthria (speech difficulty)
Diaphoresis, bradycardia, hypotension, respiratory depression, diarrhea and seizures

Question 4

Neostigmine methylsulfate (ROA and Uses, Considerations)

Answer 4

PO, SUBQ and IM

Myasthenia gravis, urinary retention, neuromuscular blockade reversal

May cause dizziness, headache, nausea, vomiting, bradycardia, hypotension, tachycardia, muscle cramps, seizures, dyspnea

Question 5

Physostigmine salicylate (ROA and Uses, Considerations)

Answer 5

IV and IM

Anticholinergic syndrome and glaucoma

Diaphoresis, hypersalivation, nausea and vomiting, bradycardia, hypotension, seizures, confusion, muscle paralysis, dyspnea and bronchospasm.

Question 6

Pyridostigmine bromide (ROA and Uses, Considerations)

Answer 6

IV

Myasthenia gravis, neuromuscular blockade reversal, nerve gas exposure prophylaxis

Nausea, vomiting, headache
Abdominal cramps and diarrhea
Bradycardia, bronchospasm
Blurred vision, diaphoresis, hypersalivation and increased urinary frequency.

Question 7

Pralidoxime chloride

Answer 7

IV

Cholinesterase inhibitor toxicity and organophosphate pesticide toxicity

Dizziness, blurred vision, headache, drowsiness, tachycardia, hypertension and hypertonia (muscle stiffness)