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Pharm > Cholinergic/Anticholinergic > Flashcards

Cholinergic/Anticholinergic Flashcards

1
Q

Direct Acting Cholinergic Agonist effect on sk. m.

A

nAChR on skeletal m.-contraction..prolonged-flaccid paralysis

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2
Q

PS effects Direct Acting Cholinergic Agonist

A 
Contraction sphincter of iris-Miosis
Contraction ciliary m. for near vision
Dec HR, dec contractility
high dose-vasoconstriction
bronchial m. contraction
stim secretion all glands
inc GI motility
relax Gi sphincters
contract detrusor/relax trigone/sphincter (urination)
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3
Q

Uses Direct Acting Cholinergic agonist

A

Glaucoma
Accomodative esotropia
GI/GU disorders

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4
Q

Direct acting cholinergic agonists agents

A 
Acetylcholine
Bethanechol
Carbachol
Pilocarpine
Varenicline (Chantix)
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5
Q

Indirect acting cholinergic agonists agents

A 
cholinesterase inhibitors
-neostigmine
-physostigmine
-pyridostigmine
-organophosphates
cholinesterase regenerators
-pralidozime
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6
Q

indirect acting cholinergic agonist effects

A

CNS
low dose-alter
high dose-generalized convulsion, coma
Same on eye, resp, GI/GU as direct acting
CV
PS and S stim (PS dominates, dec HR)
high dose-hypotension too

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7
Q

Indirect cholinergic agonist uses

A

reversal of pharmacologic paralysis
glaucoma
dementia
antidote

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8
Q

Cholinergic antagonists effects

A 
CNS-drowsiness, amnesia
Eye-cycloplegia, mydriasis, xeropthalmia
CV-low dose-dec HR, high dose-inc HR
Resp-bronchodilation, reduce secretions
GI-dec secretions, gastric emptying prolonged
GU-dec urination
sweat glands-inhibit sweating
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9
Q

cholinergic antagonist agents

A 
scopolamine-motion sickness
atropine-GI, ophthalmic, cholinergic poisoning
Resp-ipratropium
        tiotropium
oxybutynin-GU
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10
Q

cholinergic antagonist uses

A 
Parkinsons
Motion sickness
Anesthesia
Opthalmic disorders
Resp disorders
CV disorders
GI disorders
Urinary disorders
cholinergic poisoning
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11
Q

ganglion blocking drugs

A

mecamylamine

MAO-block all autonomic ganglia (PS tone dominates)

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12
Q

Cholinesterase regenerator

A

pralidoxime

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13
Q

nAChR locations

A

NMJ in sk m

autonomic ganglia

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14
Q

mAChR locations

A 
nerve
heart
sm m
glands
endothelium
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15
Q

alpha 1

A

E >NE&raquo_space;»Iso

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16
Q

Alpha 2

A

E>NE»»>Iso

17
Q

Beta 1

A

Iso>E=NE

18
Q

Beta 2

A

Iso>E»>NE

Pharm (3 decks)

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