Cholinergic and Noradrenergic Transmission Flashcards
Sympathetic ANS
Fight or flight
Parasympathetic ANS
Rest and digest
Homeostasis
Maintains constant internal environment/visceral organs
White Ramus Communications
Sympathetic preganglionic axons enter the sympathetic chain ganglion here
Grey Rami Communicans
Postganglionic axons exit the sympathetic chain through here
Rami communicans
The communicating nerve branch between the sympathetic ganglions and spinal nerve
Which fibers are adrenergic
All postganglionic sympathetic fibers
2 classes of noradrenaline receptors
Alpha-adrenergic and beta-adrenergic receptors
Alpha 1 adrenergic receptor
Smooth muscle, iris, gut, uterus, salivary glands, bladder
Alpha 2 adrenergic receptor
Presynaptic, smooth muscles, gut, brain
Beta 1 adrenergic receptor
Heart
Beta 2 adrenergic receptor
Uterus, airway smooth muscle, smooth muscle
Beta 3 adrenergic receptor
Adipose tissue
Heart adrenergic receptor type and response
B1, acceleration, contractility increases
Arterioles first adrenergic receptor type and response
A1, A2, constriction
Arterioles second adrenergic receptor type and response
B2, dilation
Bronchial muscle adrenergic receptor type and response
B2, relatation
Gastrointestinal muscle adrenergic receptor type and response
A1, A2, B2, relaxation
Uterus adrenergic receptor type and response
B2, relaxation
Pancreas first adrenergic receptor type and response
A2, reduced insulin
Pancreas second adrenergic receptor type and response
B2, increased insulin
Releasers
Help drive the release of neurotransmitters
Reuptake Inhibitors
There is an inhibition leading to a longer acting adrenaline or epinephrine at synapse
Hypertensives
Nasal decongestants and appetite suppressants
Sympathomimetic Drugs
Used for raising blood pressure by stimulating the heart and inducing vasoconstriction
Sympatholytic Drugs
Block sympathetic adrenergic system through, alpha and beta receptor antagonists, ganglionic blockers, and drugs that black sympathetic activity in the brain before signal can leave the brain
Antihypertensives
Decrease heart rate and blood pressure
Muscarinic receptor response
Excitatory or inhibitory
Nicotinic receptor response
Short and excitatory
Cholinergic neurons
Neurons that synthesize and release ACh
Function of parastmpatholytic drugs
By blocking the parasympathetic nervous system they increase heart rate, open up airways, and reduce mucous production in asthma patients