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Pharm > Cholinergic and Anticholinergic > Flashcards

Cholinergic and Anticholinergic Flashcards

1
Q

Pilocarpine

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: M-Agonist (PS-mimetic)

MOA: agonist M3 (Gq)

(+): Pupil constriction -> drainage
(-): blurred vision, bladder contration, -ino, -chrono, secretion (spit, sweat, gi)

I: Glaucoma narrow+wide
KI:

LADME: drops-> 1 day, limited systemic effects

Dose: /

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2
Q

Atropine

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: M-Antagonist (PS-lytic)

MOA: antagonist all M, competitve and rev.

(+): inhibits secretions, +chrono, -peristalsis, pupils: dilation, no accomodation
(-): constipation, hyperthermia, dry mouth, urinary retention, cns excitement, +intraocular pressure

I: bradycardia, anticholinesterase poisoning
KI:

LADME: p.o. 3h half-life

Dose:

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3
Q

Bethanecol

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: M-Agonist (PS-mimetic)

MOA: agonist M3 (Gq)

(+): +peristalsis
(-): blurred vision, bladder contration, -ino, -chrono, +secretion (spit, sweat, gi)

I: constipation, urinary retention (post-op)
KI:

LADME: p.o.

Dose: /

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4
Q

Tropicamide

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: M-Antagonist (PS-lytic)

MOA: antagonist all M, competitve and rev.

(+): pupils: dilation, no accomodation
(-): constipation, hyperthermia, dry mouth, urinary retention, cns excitement, +intraocular pressure

I: eye examination
KI:

LADME: drops

Dose:

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5
Q

Oxybutinin

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: M-Antagonist (PS-lytic)

MOA: antagonist all M, competitve and rev.

(+): inhibits smooth muscle constriction
(-): constipation, hyperthermia, dry mouth, urinary retention, cns excitement, +intraocular pressure

I: urinary incontinence
KI:

LADME: p.o.

Dose:

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6
Q

Dicycloverine

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: M-Antagonist (PS-lytic)

MOA: antagonist all M, competitve and rev.

(+): inhibits peristalsis
(-): constipation, hyperthermia, dry mouth, urinary retention, cns excitement, +intraocular pressure

I: irritable bowel syndrome
KI:

LADME: p.o.

Dose:

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7
Q

Scopolamine

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: M-Antagonist (PS-lytic)
MOA: antagonist all M, competitve and rev.

(+): central: antiemetic, amnesic, peripheral: inhibits secretions, <3 +chrono, -peristalsis, pupils: dilation, no accomodation
(-): constipation, hyperthermia, dry mouth, urinary retention, +intraocular pressure, drowsiness

I: motion sickness (, urinary incontinence, anaesthesia: amnesia, less secreations, less bronchoconstriciton, less ponv)
KI:

LADME: p.o. 4h half-life, t.d. patch lasts 2-3d

Dose:

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8
Q

Succinylcholine

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: N-Agonist
MOA: depolarizing neuomuscular blockade

(+): paralysis
(-): malignant hyperthermia, hyper-K, <3 -chrono, -ino, muscle pain, +intraocular pressure (M-action)

I: fascilitates intubation
KI:

LADME: i.v., minutes, hydrolysed by CE
Dose:

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9
Q

Pancuronium

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: N-Antagonist
MOA: non-depolarizing neuomuscular blockade

(+): paralysis
(-): tachycardia (M-block)

I: fascilitates intubation and ventilation, surgery: muscle relaxation
KI:

LADME: i.v. 2-3h half-life, renal!
Dose:

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10
Q

Vecuronium

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: N-Antagonist
MOA: non-depolarizing neuomuscular blockade

(+): paralysis
(-): tachycardia (M-block)

I: fascilitates intubation and ventilation, surgery: muscle relaxation
KI:

LADME: i.v. 2-3h half-life, renal!
Dose:

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11
Q

Rocuronium

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: N-Antagonist
MOA: non-depolarizing neuomuscular blockade

(+): paralysis
(-): tachycardia (M-block)

I: fascilitates intubation and ventilation, surgery: muscle relaxation
KI:

LADME: i.v. 2-3h half-life, renal!
Dose:

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12
Q

Atracurium

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: N-Antagonist
MOA: non-depolarizing neuomuscular blockade, reversible and competitive

(+): paralysis
(-): minor (histamine release)

I: fascilitates intubation and ventilation, surgery: muscle relaxation
KI:

LADME: i.v. 30min half-life, Hofmann elimination
Dose:

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13
Q

Cisatracurium

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: N-Antagonist
MOA: non-depolarizing neuomuscular blockade, reversible and competitive

(+): paralysis
(-): minor (histamine release)

I: fascilitates intubation and ventilation, surgery: muscle relaxation
KI:

LADME: i.v. ? half-life, Hofmann elimination
Dose:

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14
Q

Neostigmine

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: Anti-CE (PS-mimetic)
MOA: binds and carbamylates CE -> reversible inhibition -> +Ach

(+): depolarisation at neuromuscular junction
(-): bronchoconstriction, asthma exacerbation, cns: agitation, dreaming, muscles: twitching, +secretions, <3 -chrono, - ino, +peristalsis

I: Myasthenia gravis, reversal of pancuronium&co, post-op urinary retention
KI:

LADME: i.v. or p.o. (low penetration), 1h half-life
Dose: atropine reduces ps-effects

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15
Q

Pyridostigmine

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: Anti-CE (PS-mimetic)
MOA: binds and carbamylates CE -> reversible inhibition -> +Ach

(+): depolarisation at neuromuscular junction
(-): bronchoconstriction, asthma exacerbation, cns: agitation, dreaming, muscles: twitching, +secretions, <3 -chrono, - ino, +peristalsis

I: Myasthenia gravis
KI:

LADME: i.v. or p.o. (low penetration), 1h half-life
Dose: atropine reduces ps-effects

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16
Q

Physostigmine

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: Anti-CE (PS-mimetic)
MOA: binds and carbamylates CE -> reversible inhibition -> +Ach

(+): -intraocular pressure
(-): bronchoconstriction, asthma exacerbation, cns: agitation, dreaming, muscles: twitching, +secretions, <3 -chrono, - ino, +peristalsis

I: glaucoma
KI:

LADME: i.v. or p.o. (low penetration), 1h half-life
Dose: atropine reduces ps-effects

17
Q

Edrophonium

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: Anti-CE (PS-mimetic)
MOA: binds CE -> reversible inhibition -> +Ach

(+): depolarisation at neuromuscular junction
(-): bronchoconstriction, asthma exacerbation, cns: agitation, dreaming, muscles: twitching, +secretions, <3 -chrono, - ino, +peristalsis

I: dx myasthenia gravis, find dose of neo/physostigmine
KI:

LADME: i.v. or i.m., 10min action
Dose: atropine reduces ps-effects

18
Q

Echothiophate

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: Organophosphate
MOA: binds CE irreversibly -> +Ach, +PS

(+): -intraocular pressure
(-): +secretions, <3 -chrono, - ino, +peristalsisparalysis, bronchoconstriction, cns: agitation, dreaming, muscles: twitching, death

I: insecticide etc. (Glaucoma)
KI:

LADME: long half-life, a via skin/lung/gi
Dose: /

19
Q

Dyflos

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: Organophosphate
MOA: binds CE irreversibly -> +Ach, +PS

(+): -intraocular pressure
(-): +secretions, <3 -chrono, - ino, +peristalsisparalysis, bronchoconstriction, cns: agitation, dreaming, muscles: twitching, death

I: insecticide etc. (Glaucoma)
KI:

LADME: long half-life, a via skin/lung/gi
Dose: /

20
Q

Sarin

Class?
MOA?

Effects +/-?

Use/ci?

LADME?
Dose?

A

Class: Organophosphate
MOA: binds CE irreversibly -> +Ach, +PS

(+): -intraocular pressure
(-): +secretions, <3 -chrono, - ino, +peristalsisparalysis, bronchoconstriction, cns: agitation, dreaming, muscles: twitching, death

I: insecticide etc. (Glaucoma)
KI:

LADME: long half-life, a via skin/lung/gi
Dose: /

Pharm (2 decks)

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