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*Pharm Exam 2 > Cholinergic Agonists and Antagonists > Flashcards

Cholinergic Agonists and Antagonists Flashcards

1
Q

What is the MOA of nicotine?

A

activation of neuronal nicotinic receptors

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2
Q

What is the MOA of succinylcholine?

A

depolarizing block of muscle nicotinic receptors

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3
Q

What is the MOA of acetylcholine?

A

nicotinic and muscarinic agonist

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4
Q

What is the MOA of methacholine?

A

muscarinic agonist

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5
Q

What is the MOA of carbachol?

A

nicotinic and muscarinic agonist

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6
Q

What is the MOA of bethanechol?

A

muscarinic agonist

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7
Q

What is the MOA of pilocarpine?

A

muscarinic agonist

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8
Q

What is the MOA of neostigmine?

A

AChE inhibitor

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9
Q

What is the MOA of edrophonium?

A

AChE inhibitor

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10
Q

What is the MOA of physostigmine?

A

reversible AChE inhibitor

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11
Q

What is the MOA of donepezil?

A

reversible AChE inhibitor

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12
Q

What is the MOA of pralidoxime?

A

peripheral AChE reactivator

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13
Q

What is the MOA of echothiophate?

A

irreversible AChE inhibitor

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14
Q

What is the MOA of atropine?

A

muscarinic antagonist

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15
Q

What is the MOA of scopolamine?

A

muscarinic antagonist

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16
Q

What is the MOA of glycopyrrolate?

A

muscarinic receptor antagonist

17
Q

What is the indication for nicotine?

A

withdrawal symptoms of smoking cessation

18
Q

What is the indication for succinylcholine?

A

neuromuscular block for electroconvulsive shock therapy or emergency intubation

19
Q

What is the indication for acetylcoline?

A

none

20
Q

What is the indication for methacholine?

A

diagnosis of subclinical asthma or test for severity of asthma

21
Q

What is the indication for carbachol?

A

miotic agent in ocular surgery to reduce pressure following ocular surgery

22
Q

What is the indication for bethanechol?

A

urinary retention, bladder atony

23
Q

What is the indication for pilocarpine?

A

dry mouth from head and neck radiation or Sjogren’s syndrome; narrow angle glaucoma

24
Q

What is the indication for neostigmine?

A

myasthenia gravis, reversal of neuromuscular block

25
Q

What is the indication for edrophonium?

A

diagnosis of myasthenia gravis, reversal of neuromuscular block

26
Q

What is the indication for physostigmine?

A

delirium from anticholinergic drugs, glaucoma

27
Q

What is the indication for denopezil?

A

diagnosis of Alzheimer’s

28
Q

What is the indication for pralidoxime?

A

respiratory muscle weakness in organophosphate poisoning

29
Q

What is the indication for echothiophate?

A

open angle glaucoma

30
Q

What is the indication for atropine?

A

excess secretions during surgery, increased frequency and urgency associated w/ cystitis, hypertonic gut, organophosphate poisoning, bradycardia

31
Q

What is the indication for scopolamine?

A

motion sickness, anti-salilagogue in surgery

32
Q

What is the indication for glycopyrrolate?

A

protects against excessive muscarinic activation during reversal of neuromuscular blockade, anti-salilagogue

33
Q

What is the HL of acetylcholine? How is it eliminated?

A

~150 msec; AChE

34
Q

How is succinylcholine broken down?

A

butyrl cholinesterase

35
Q

What is the HL of pilocarpine?

A

~1 hr

36
Q

What is the HL of edrophonium?

A

~10 mins

37
Q

What is the HL of pralidoxime?

A

~75 mins

38
Q

What is the HL of echothiophate?

A

not exactly known, but very long

*Pharm Exam 2 (4 decks)

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