Cholinergic Agonist

Question 1

Direct Acting Nicotinic Agonist

Answer 1

Nicotine

Question 2

Direct Acting Nicotinic and Muscarinic Agonist

Answer 2

Carbechol (Miostat)

• Miosis
• Relieves intraocular pressure

Question 3

Direct Acting Muscarinic Agonist

Answer 3

Bathanechol (Urecholine)

• Smooth Muscle activation of GI tract and Bladder
• Urination
• Short Acting
• No CNS

Pilocarpine (Salagen)

• Less Potent
• Enter CNS
• Topical Miosis
• Secretion of Sweat, Tears, Saliva
• Sjorgens Syndrome

Question 4

Indirect Acting Reversible Cholinergic Agonist

Answer 4

• Edrophonium (Enlon)
• 10-20min
• Edrophonium Test for Myasthenia Gravis
• Physostigmine
• 30min-2 hours
• Enter CNS
• For Anticholingergic overdose
• Glaucoma

-Neostigmine
-30min- 4hrs
-Cannot Enter CNS
-Great Effect on SKM
Stimulate GI + Bladder
-Antidote for NM blocker
-Treatment for MG

• Pyridostigmine
• 4-6hrs
• Treatment for MG

Question 5

Indirect Acting IRREVERSIBLE Cholinergic Agonist

Answer 5

Echothiophate

-For glaucoma

Question 6

Organophosphate Poisoning Therapy

Answer 6

• Pralidoxime (2-PAM)
• Reactivate AchE
• Cannot enter CNS

Atropine
-Competitive Inhibitor of Muscarinic receptor