Cholesterol Flashcards
4 groups of patients who should be taking statins
- those with clinical ASCVD (past stroke, MI) regardless of LDL
- Those with LDL at or ↑ 190 mg/dL
- Those with DM (without evidence of clinical ASCVD) with LDL 70-189 mg/dL
- Those 40-75 y/o without clinical ASCVD or DM with LDL 70-189 mg/dL AND ASCVD risk >7.5%
who should be on “high intensity” statin therapy?
groups 1 and 2, group 3 if 10 year ASCVD score > 7.5%
who should be on “moderate intensity” statin therapy?
group 3 - start moderate based on risk factors (then go to high if needed)
and group 4
who should be on “low intensity” statin therapy?
no one really.
lovastatin, pravastatin, simvastatin, fluvastatin, atorvastatin, rosuvastatin (which one is the prototype?)
HMG-CoA Reductase Inhibitors (statins)
colestipol, colesevelam, cholestyramine
which one is the prototype?
Bile Acid Sequestrants
which statins are high intensity statins (2)
atorvastatin & rosuvastatin
which statins are moderate intensity statins (6)
atorvastatin & rosuvastatin plus pravastatin, simvastatin, fluvastatin, and lovastatin
category D & X drugs
D = ACEs, ARBs, DRIs X = statins
class of antilipidemics used mostly for hypertriglyceridemia?
fibric acid derivatives
medication associated with gallstones? it is both an adverse effect & contraindication
gemfibrozil (fibric acid derivative)
contraindications are myopathy, gallstones, & liver injury
fibric acid derivatives
promotes athersclerotic plaque stability, reduces inflammation, improves endothelial fx, enhances vasodilation & reduces thrombus risk
statins
indications include: hypercholesterolemia, primary prevention of hypercholesterolemia, post MI, and DM
statins
contraindications include liver disease, viral hepatitis, alcoholic cirrhosis
statins
adverse effects include new onset DM, myopathy, rhabdo, hepatotoxicity
statins
most common drug that causes rhabdo
rosuvastatin
