Cholesterol Flashcards
4 groups of patients who should be taking statins
- those with clinical ASCVD (past stroke, MI) regardless of LDL
- Those with LDL at or ↑ 190 mg/dL
- Those with DM (without evidence of clinical ASCVD) with LDL 70-189 mg/dL
- Those 40-75 y/o without clinical ASCVD or DM with LDL 70-189 mg/dL AND ASCVD risk >7.5%
who should be on “high intensity” statin therapy?
groups 1 and 2, group 3 if 10 year ASCVD score > 7.5%
who should be on “moderate intensity” statin therapy?
group 3 - start moderate based on risk factors (then go to high if needed)
and group 4
who should be on “low intensity” statin therapy?
no one really.
lovastatin, pravastatin, simvastatin, fluvastatin, atorvastatin, rosuvastatin (which one is the prototype?)
HMG-CoA Reductase Inhibitors (statins)
colestipol, colesevelam, cholestyramine
which one is the prototype?
Bile Acid Sequestrants
which statins are high intensity statins (2)
atorvastatin & rosuvastatin
which statins are moderate intensity statins (6)
atorvastatin & rosuvastatin plus pravastatin, simvastatin, fluvastatin, and lovastatin
category D & X drugs
D = ACEs, ARBs, DRIs X = statins
class of antilipidemics used mostly for hypertriglyceridemia?
fibric acid derivatives
medication associated with gallstones? it is both an adverse effect & contraindication
gemfibrozil (fibric acid derivative)
contraindications are myopathy, gallstones, & liver injury
fibric acid derivatives
promotes athersclerotic plaque stability, reduces inflammation, improves endothelial fx, enhances vasodilation & reduces thrombus risk
statins
indications include: hypercholesterolemia, primary prevention of hypercholesterolemia, post MI, and DM
statins
contraindications include liver disease, viral hepatitis, alcoholic cirrhosis
statins
