Cholesteatoma and mastoiditis Flashcards
What is a cholesteatoma?
It is a three-dimensional collection of epidermal and connective tissues within the middle ear. Its significance lies in the fact that it grows independently and can be locally invasive and destructive, particularly affecting the bones of the middle ear.
What is the pathophysiology of cholesteatoma?
Chronic negative middle-ear pressure due to dysfunction of the eustachian tube causes the tympanic membrane to be sucked back and retract. As this process continues, there is bone erosion.
Bone erosion (epitympanum) occurs mainly by pressure but release of osteolytic enzymes has been detected at the peripheral margins of the lesion. This erosion produces a slowly expanding defect.
A ‘retraction pocket’ lined by squamous, non-keratinising epithelium is thus formed. The erosion often goes on, as the ball of epithelium grows, to surround the ossicles and may extend into the mastoid bone, the lateral semicircular canal, the middle cranial fossa and the posterior cranial fossa.
The (usually) unilateral lesion can give rise to a spectrum of problems, ranging from painless otorrhoea (discharge from the ear) through to serious central nervous system complications.
What are the different types of cholesteatoma?
Congenital
Primary acquired
Secondary acquired
What is congenital cholesteatoma?
Occurs when squamous epithelium becomes trapped within the temporal bone during embryogenesis. It expands, resulting in conductive hearing loss either through obstruction of the Eustachian tube.
What is primary acquired cholesteatoma?
Accounts for 80% of all cases.
Follows pathophysiology of cholesteatoma
What is secondary acquired cholesteatoma?
Arises as a result of insult to the tympanic membrane such as perforation secondary to acute otitis media or trauma.
What is the presentation of cholesteatoma?
Progressive conductive hearing loss
Vertigo
Headache
Facial nerve palsy
Ear discharge (which may be foul-smelling)
Recurrent otitis poorly responsive to treatment
Tympanic membrane perforation
What are the risk factors for cholesteatoma?
Cleft palate
Ear trauma
What are the differentials of cholesteatoma?
Otitis media with effusion
Otitis externa
Tympanosclerosis
Osteonecrosis
What are the investigations for cholesteatoma?
CT imaging
MRI scan if there is concern about soft tissue involvement such as herniated brain or epidural abscess
What is the management of cholesteatoma?
Medical therapy is reserved for those patients who refuse surgery or for whom a general anaesthetic would be too dangerous owing to comorbidity. In these patients, regular ear cleaning with treatment of infections (topical ± systemic antibiotics) is advised but, ultimately, this will not prevent cholesteatoma growth with its consequences.
Surgery to remove the cholesteatoma and leave a safe, dry ear.
What are the complications of cholesteatoma?
Perichondritis Chondritis Ear canal stenosis Facial nerve injury Long-term dizziness
Where is the mastoid process?
The mastoid process is an inferior extension of the petrous temporal bone of the skull and provides a structural function as an anchor point for the large muscles of the neck. It contains multiple air cells that develop from a single main cavity (the antrum), after the age of about 2.
What is mastoiditis?
Mastoiditis occurs when suppurative infection extends from a middle ear affected by otitis media to the mastoid air cells. The infective process causes inflammation of the mastoid and surrounding tissues and may lead to bony destruction.
The mastoid air cells are related superiorly to the middle cranial fossa and posteriorly to the posterior cranial fossa. This means that suppuration in the mastoid may, rarely, spread to cause meningitis or a cerebral abscess.
What is the classification of mastoiditis?
Acute mastoiditis is defined as an acute inflammation of the mastoid with colliquation of the air-filled mastoidal bone.
Chronic, latent, or masked, mastoiditis presents in a chronic, or subclinical, fashion. It is usually associated with chronic suppurative otitis media or cholesteatoma.
What are the risk factors for mastoiditis?
Young children
Immunosuppressed patients
Cholesteatoma
Most common organism is s. pneumoniae. Others include H. influenzae, pseudomonas, Moraxella catarrhalis
What is the presentation of mastoiditis?
History of acute or recurrent episodes of otitis media.
Intense otalgia and pain behind the ear.
Fever.
Infants may present with irritability, intractable crying and feeding problems.
Swelling, redness or a boggy, tender mass behind the ear.
The external ear may protrude forwards; fluctuance can sometimes be demonstrated behind the ear (examine from behind).
Ear discharge may be present and the eardrum may be perforated.
Tympanic membrane bulges and is erythematous.
The patient is unwell.
What are the differentials of mastoiditis?
Otitis media or externa Trauma Meningitis Cellulitis Parotid swelling Bone cysts
What are the investigations for mastoiditis?
Blood tests inc. FBC, ESR Blood cultures CT LP if brain spread suspected MRI Skull X-ray Audiogram to monitor the hearing loss
What is the management of mastoiditis?
Managed in a hospital setting
The usual initial therapy is high-dose, broad-spectrum intravenous (IV) antibiotics, given for at least 1-2 days (eg, with a third-generation cephalosporin).
Oral antibiotics are usually used after this, starting on IV treatment after 48 hours without a fever and continuing for at least 1-2 weeks.
Paracetamol, ibuprofen and other agents may be given as antipyretics and/or painkillers.
Myringotomy ± tympanostomy tube insertion may be performed in some cases as a therapeutic procedure, or to collect middle ear fluid for culture.
Immediate mastoidectomy is usually the method of choice to treat acute mastoiditis with subperiosteal abscess formation
What are the complications of mastoiditis?
Labyrinthitis Osteomyelitis Subperiosteal abscess Cranial nerve palsies Petrositis Lateral sinus thrombosis
What is otosclerosis?
Otosclerosis describes the replacement of normal bone by vascular spongy bone.
It causes progressive conductive deafness due to fixation of the stapes at the oval window. Otosclerosis is autosomal dominant and typically affects young adults.
What are the risk factors for otosclerosis?
Race- more common in white and Asian populations.
Sex- more commonly diagnosed in women
Age- presents between teen years and middle age.
What is the presentation of otosclerosis?
Onset is usually at 20-40 years - features include:
Progressive conductive deafness
Tinnitus worsens as hearing loss worsens
Vestibular symptoms are usually absent
Tuning fork tests reveal conductive pattern deafness
Normal tympanic membrane*
Positive family history
*10% of patients may have a ‘flamingo tinge’, caused by hyperaemia- the Schwartze sign