Cholangiocarcinoma Flashcards
What is cholangiocarcinoma?
Cancer of the biliary system.
It can occur at any site but most commonly in extrahepatic biliary system
What is the most common site for bile duct cancers?
Bifurcation of the right and left hepatic ducts (Klatskin tumours)
Nature of Klatskin tumours
Slow-growing tumours that invade locally
They metastasise to local lymph nodes before spreading distally.
They then spread to peritoneal cavity, lung and liver.
Epidemiology
Two thirds of cases in patients >65 years
Higher incidence in SE asia due to chronic endemic parasitic infections from liver flukes.
Cholangiocarcinoma histology.
95% are adenocarcinomas from cholangiocytes within the biliary tree.
Remaining are SCC, or even rarer like sarcomas, lymphomas and small cell cancers
Risk factors
PSC
UC
Infective like liver flukes, HIV, hepatitis viruses
Toxins like chemical in rubber and aircraft industry
Congenital (Caroli’s disease, choledochal cyst)
Alcohol excess
Dm
Clinical features
Generally asymptomatic until late stage
Post-hepatic jaundice + pruritus
Pale stools and dark urine
Less commonly…
RUQ pain, early satiety, weight loss, anorexia and malaise
Examination findings
Jaundice and cachexia
Courvoisier’s law can be applied
Explain Courvoisier’s law.
If there is presence of jaundice and an enlarged or palpable gallbladder
-> malignancy of the biliary tree or pancrease should be strongly suspected since the cause is unlikely to be gallstones.
Dx
Post-hepatic jaundice causes
Obstructive choledocholithiasis
Bile duct strictures
Choledochal cysts
External compression from extra-biliary tumours like…
Benign biliary tumours
Pancreatic tumours
PBC
PSC
Lab tests
Biochemistry for bilirubin, ALP and gamma-GT
Tumour markers - CEA and CA19-9 may also be elevated
Imaging
USS may be used initially to confirm an obstructive cause.
MRCP is the optimal imaging for diagnosis
ERCP can demonstrate site of obstruction and can also be used to obtain smaples for cytology and histology.
How is staging assessed?
CT imaging
It is better than MRI because it is better at locating distant metastases
Angiography may be used in pre-op planning to image the hepatic arteries or portal vein
Definitive management
Complete surgical resection (majority of patients have inoperable disease at time of presentation however)
Management of intrahepatic Klatskin tumours
Partial hepatectomy and reconstruction of the biliary tree