Chimiothérapies Flashcards

1
Q

Adriamycine : autre nom + catégorie

A

Doxorubicine

Anthracycline = Anti-topo II + agent intercalant

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2
Q

Vincristine : catégorie

A

Poison du fuseau > inhibiteur polymérisation = vinca-alcaloïde

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3
Q

EI vincristine

A

Neutropénie

Neuropathie sensitive végétative

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4
Q

EI adriamycine

A

Toxicité cardiaque cumulative +++

Toxicité cutanée si extravasation (nécrose)

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5
Q

Inhibiteurs topo-isomérase : sous catégories

A

Topo I : camptothécine –> irinotécan
Topo II :
- Intercalant : adriamycine/doxorubicine
- Non intercalant : étoposide

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6
Q

Catégorie bléomycine

A

Alkylant : radio-mimétique induisant cassures ADN

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7
Q

Chimiothérapie dont EI est cystite hémorragique

A

Cyclophosphamide (endoxan) < moutarde azotée < alkylant

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8
Q

Chimiothérapies fortement émetisantes

A

Anthracyclines

Cisplatine

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9
Q

Prévention des vomissements aigus post-chimiothérapie

A

Ondensétron (5HT3) / Aprépitant (NK1) / Corticoïdes

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10
Q

Prévention des vomissements tardifs post-chimiothérapie

A

Aprépitant (NK1) / Corticoïdes

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11
Q

Anti-émétique anti-NK1 : lequel + indication chimiothérapie

A

aprépitant (= emende)

Vomissements aigus + tardifs post chimiothérapie

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12
Q

Anti-émétique anti-5HT3 : lequel + indication chimiothérapie

A

Ondansétron

Vomissements aigus

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