Chimio Flashcards

1
Q

Toxicité du cisplatine

A

NEUROLOGIQUE : périphérique
OTOTOXICITÉ: cochleovestibulaire
NEPHROLOGIQUE : tubulaire

NON mémo

Toujours hydrater avant donner cette chimio

Attention oxaliplatine que neuropathie

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Toxicité du 5-FU :

A

Cardiaque : spasme coronaire

Synd pied lainé erythro dysesthesies palmo plantaire

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Folfox =

A

Oxaliplatine + 5-FU+ acide folique

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Chimio alopeciante

A

Taxane
Antracyclines
Cyclophosphamides
Etoposide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Toxicité ciclophosphamide

A
Cystites hémorragique 
K vessie 
Encéphalopathie 
Risque stérilité 
SIADH
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Toxicité anthracyclines

A

Toxicité cardiaque cumulative = cardiomyopathie

Faire ETT avant donner ttt à faire tous les 3 mois et mesurer FEVG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Toxicité bleomycine

A

Fibrose pulmonaire

Faire EFR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Bevacizumab type Ac et EI

A
Ac monoclonal anti VEGF : antiangiogéniques 
EI: 
Protéinurie 
HTA
Retard cicatrisation 
Hémorragie
Thrombose
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

EI cytarabine

A
  • cytopenie
  • alopécie
  • synd cérébelleux
  • réaction cut
  • tox hépatique
  • fievre
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Toxicité taxanes et action

A

Inh Dépolymérisation de la tubuline

Tox :

  • neuro
  • hémato
  • dig
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Ttt anti émétisant

A
  • aprépitant
  • benzamides substitues (primperan)
  • setrons (anti 5HT3) Ac récepteurs sérotonine
  • cortico
  • BZD
  • metoclopramide : neuroleptique (anti dopaminergique stimule motricité gastrique )
  • domperidone
  • metopimazine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Toxicité oxaliplatine

A

Neuro

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Comment agissent les inhibiteurs de point de contrôle immunitaire

A

Ac monoclonaux stimulant le système immunitaire

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Trastuzumab indications /voie administration / toxicité

A
Contre Her2
Anticorps monoclonal 
Administration SC 
Ttt cancer sein Her2+++ et dans cancer estomac métastatique 
Toxicité cardiaque réversible
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Avant donner plaxitaxel quelle pemedication faire

A

Antihistaminique 1 ère gé

How well did you know this?
1
Not at all
2
3
4
5
Perfectly