Chimie AB

Question 1

Fluoroquinolones

Answer 1

2 gen:
Norfloxacin
Ciproflixacin

3e gen:
Ofloxacine
Levoflixacine

4e gen
Moxifloxacine

Question 2

Norfloxacin

Answer 2

Noroxin
Norflox

Question 3

Ciprofloxacine

Answer 3

Cipro
Ciloxan

Question 4

Oflixacine

Answer 4

Floxin
Ocuflox

Question 5

Levofloxacine

Answer 5

Levaquin

Question 6

Moxifloxacine

Answer 6

Avelox
Vigamox

Question 7

Inh synthèse et fct ADN

Answer 7

Sulfonamide
Trimethoprime
Quinolones, fluoroquinolones

Question 8

Inh paroi cell

Answer 8

B lactamine
Autres

Question 9

B lactamine

Answer 9

Pénicilline
Cephalosporine
Monobactam
Carbapenem

Question 10

Autres inh paroi cell

Answer 10

Bacitracine
Vancomycine
Daptomycine

Question 11

Pen fermentation

Answer 11

Pénicilline G
pénicilline V

Question 12

Pen semi-synt résistante B lactamamase Po

Answer 12

Cloxacilline

Question 13

Pen semi-synt large spectre Po

Answer 13

Ampicilline
Amoxicilline
Pivampicilline

Question 14

Pen IV

Answer 14

Carbenicilline
Carfecilline

Question 15

Étude structure activité cephalosporine

Answer 15

-act plus faible que pen
-Spectre plus intéressant que Pen
-Biod PO depend: NH2 en 7 , gr non chargé en 3
-bouclier stérique: diminue act
- apparition rapide résistance surtout pr gram-

Question 16

Céphalosporine 1 gen

Answer 16

Cephalexine
Cefadroxil

Question 17

Cephalosporine 2 gen PO

Answer 17

Cefaclor
Cefprozil
Cefuroxime axetil

Question 18

Cephalosporine 3e gen

Answer 18

Cefixime

Question 19

Études relation structure activité pen

Answer 19

-présence gr hydrophobe chaîne lat: augmente act gram +
- augmente caractère hydrophobe: pas de changement gram+ , diminue act gram-
- gr hydrophile: augmente act gram-

Question 20

Acide clavulanique

Answer 20

Peu act antibact
Puissant inh b lactamases
Avec Pen pr:
diminuer dose Pen
Aug spectre act

Question 21

Tetracyclines

Answer 21

Tetracycline
Doxycycline
Monocycline

Question 22

Macrolides

Answer 22

Erythromycine
Clarythromycine
Azithromycine