Childrens Ortho Flashcards
A child’s skeleton has how many bones?
270
What does the physis describe?
The areas from which long bone growth occurs post-natally
How do flat bones develop in utero?
Intramembranous ossification
Mysenchymal cells -> bone
How do long bones develop in utero?
Endochondral ossification
Mesenchymal cells -> cartilage -> bones
Outline the process of intramembranous ossification
- Condensation of mesenchymal cells which differentiate into osteoblasts - Ossification centre forms
- Secreted osteoid traps osteoblasts which become osteocytes
- Immature woven trabecular matrix and periosteum form
- Compact bone develops superficial to cancellous bone. Crowded blood vessels condense into red bone marrow
What bones are formed by intramembranous ossification?
Flat bones of skull, clavicle and mandible
Intramembranous ossification describes the bone development from what origin?
Fibrous membranes
What is the cell templates for intramembranous ossification?
Mesenchymal cells
What is endochondral ossification?
Development of long bone by replacing the hyaline cartilage precursor
Does endochondral or intramembranous ossification take longer?
Endochondral
What are primary ossification centres?
Sites of pre-natal bone growth through endochondral ossification from the central part of the bone
What are secondary ossification centres?
Occurs post-natal after the primary ossification centre and long bones often have several (the physis)
Outline the process of primary endochondral ossification
PRIMARY endochondral ossification1. Mesenchymal differentiation at the primary centre2. The cartilage model of the future bony skeleton forms3. Capillaries penetrate cartilage.> Calcification at the primary ossification centre - spongy bone forms> Perichondrium transforms into periosteum4. Cartilage and chondrocytes continue to grow at ends of the bone5. Secondary ossification centres develop with its own blood vessel and calcification at the proximal and distal end - calcification of the matrix6. Cartilage remains at epiphyseal (growth) plate and at joint surface as articular cartilage.
Outline the process of secondary ossification
ossification occurs at the physis
• basically interstitial growth
• proliferation of chondrocytes and the subsequent calcification of the extracellular matrix into immature bone that is then subsequently remodelled
What is the role of secondary ossification in children?
• physis is responsible for the skeletal growth of a child
• any congenital malfunction to this area or acquired insult - whether it is traumatic/infective or otherwise will therefore have a subsequent impact on growth of the child