Children and Adolescent Psychiatry Flashcards
When do mental health problems start?
Childhood
Pre-conception factors influencing mental health
Genetics
Which mental health problems are highly genetic?
ADHD
autism
Which mental health problems are substantially genetic?
Depression
Anxiety
Post conception factors influencing mental health
Maternal health
- antibodies
- obesity
- DM
Substance misuse (alcohol, marijuana)
Toxins (lead, mercury)
Drugs (esp psychotropics, antiepileptics)
Epigenetics (folate controlled methylation)
Endocrine environment - especially androgens
Immune environment
Premature birth / perinatal complications
Twinning
What substance is linked to depression later on in childhood?
marijuana
In an androgen environment, what is more likely to develop?
Autism
ADHD in boys
What is premature birth / perinatal complications related to?
impaired development of attention and cognition - those being associated with ADHD
Presentation of foetal alcohol syndrome
Growth retardation (body, head, brain (inc. cerebellum), eyes Sensorimotor effects cognitive development effects executive function effects language effects characteristic appearance - short palpebral fissure length in eyes - thin upper lip - smooth / absent philtrum Grey matter gyrification - increased cortical complexity
Outcomes of foetal alcohol syndrome
Highly variable clinical picture Learning difficulties Conduct disorders (ODD) Combined ADHD or ADD or hyp-imp subtypes Anxiety disorders
What does ODD stand for?
Oppositional defiant disorder
Presentation of ODD
Frequent loss of temper Arguing becoming easily angered or annoyed showing vindictive, spiteful or other negativistic behaviours Behaviour is learned - enacted to obtain a desired result Oppositional defiance Refused to obey adults request Deliberately annoys people Touch of easily annoyed by others
Presentation of ADHD
Distractibility sustaining attention to tasks that provide high level of stimulation or frequent rewards problems with organisation Impulsive aggression Poor cognition often remorseful resistant to pure behaviour management
Presentation of Hyp-imp subtypes disorders
Difficulties with remaining still - more evident in situations that require behavioural self control
Impulsivity
What is white matter connectivity important for?
Functions that require interplay between brain areas e.g. working memory between hippocampus and anterior cingulate
What is low connectivity of white matter associated with?
More ‘neural noise’ in the system
cognitive instability
Poor integration of function
===»> ADHD
Environmental factors during childhood influencing mental health
Carer-child relationship (attachment) Parenting skills Parental mental disorder Marital harmony / family function Abuse / neglect Discipline (too much is associated with mental health problems) Day care and schooling Peer relationships life events physical disability
What does early life stress influence in the brain?
The function of the limbic circuit including amygdala and determines the subsequent patterns of stress response (resilient or flight)
mood and patterns of response to threat including withdrawl and/or aggressive response
What does experience of adversity do?
Trains the brain to adapt to a hostile environment
- limbic response and heightened amyglada activity
- cortical response and preparation of aggressive response
- behavioural response and aggression
What happens in reward based learning?
Dopamine neurones fire when you associate an action with a subsequent reward
Association between early adversity and reward based learning
early adversity decreases DA response - so have to behave a bit more to get the reward = the hypoactive reward response
What does the hypoactive reward response underpin?
underpins a variety of conditions e.g. addiction (obesity, drugs, alcohol, gambling, porn) and increases delay aversion
Features of executive function and cortical control
Taking control over automatic and learned behaviours
inhibit prepotent responses
intentional decision making and forward planning
requires self awareness and capacity to self monitor
Delay aversion and ADHD
Inability to wait and maintain attention in the absence of an immediate reward
What does the social brain reflect?
Increased understanding, reflection and control with age
What does carers negative emotion in the clinical predict?
Rates of relapse of chronic illness
Mental health issues associated with school
Fear of leaving home
Fear of going to school
Unwilling to go to school
Unwilling to leave home