Childhood Functional GI disorders and GERD Flashcards

1
Q

What are functional GI disorders

A

disorders of the digestive system in which symtpoms cannot be explained by the presence of structural or tissue abormality based on clinical symptoms

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2
Q

Types of functional GI disorders

A
G1. infant regurgitation
G2. Infant rumination syndrome
G3. Cyclic vomiting syndrome
G4. Infant colic
G5. Functional diarrhea
G6. Infant dyschezia
G7. Functional constipation
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3
Q

Diagnostic criteria for infant regurgitation

A

must include all the follwing in otherwise healthy infants 3 weeks to 12 months of age

  • regurgitation 2 or more times per day for 3 or more weeks
  • no retching, hematemesis, aspiration, apnea, failure to thrive, feeding or swallowing difficulties, abnormal posturing
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4
Q

Diagnostic criteria for infant rumination syndrome

A

must include all the following for at least 3 months

  1. repetitive contractions of abdominal msucles, diaphragm and tongue
  2. Regurgitation of gastric content into the mouth which can also be reswallowed
  3. three or more of the following
    - onset between 3mo and 8mo
    - does not responed to management for GERD and anticholinergic drugs, formula changing…
    - unaccompanied y signs of nausea or distress
    - does not occur during sleep and when infant is interacting with others
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5
Q

Diagnostic Criteria for Cyclic Vomiting Syndrome

A

must include both:

  • two or more periods of intense nausea and unremitting vomiting or retchign lasting hours to days
  • return to usual state lasting weeks to months
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6
Q

Diagnostic Criteria for Infant Colic

A

must include all of the follwing from birth to 4 mo of age

  • paroxysms of irritability, fussing, crying that start and stop wihtout abvious cause
  • episodes lasting 3 or more hours per day and occuring at least 3 days per week for at least 1 week
  • no failure to thrive
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7
Q

Diagnostic Criteria for Functional Diarrhea

A

must include all of the following

  • daily painless, recurrent passage of 3 or more large, unformed stools
  • Symtpoms that last more than 4 weeks
  • onset of symtpoms that begins between 6 and 36 motnhs of age
  • pasasge of stools that occurs during waking horus
  • there is no failure to thrive if caloric intake is adequate
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8
Q

Diagnostic Criteria for Infant Dyschezia

A

must include both in an infant younger than 6 months

  • at least 10 minutes of straning and crying before successful passage of soft stools
  • no other health problems
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9
Q

Diagnostic Criteria for Functional Constipation

A

must include 1 month of at least 2 of the follwing in infants up to 4 years of age

  • two or fewer defecations per week
  • at least 1 episode per week of incontinence after the acquisition of toileting skills
  • history of stool retention
  • history of painful or hard bowel movements
  • resence of a large fecal mass in the rectum
  • histroy of large diameter stools that may obstruct the toilet
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10
Q

Irritable Bowel Syndrome

A

must include all of the follwing

  1. abdominal pain at least 4 day per month associated with one or more of the follwing:
    - related to defecation
    - a change in frequency of stool
    - a change in form of stool
  2. in children with constipation, the pain does not resolve with resolution of the constipation
  3. After appropriate evaluation, the symtpoms cannot be fully explained by other conditions
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11
Q

Functional dyspepsia

A

must include 1 or more of the follqing for at least 4 days per month

  • postprandial fullness
  • early satiation
  • epigastric pain or burning not associates with defecation
  • after appropriate evaluation the symtpoms cannot be fully explained by another medical condition
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12
Q

Functional Nausea

A

must include all of the follwing for the last 2 months

  • boterhsome nausea as the presominant symtpom, at least twice per week and generally not related to meals
  • no consistently associated with vomiting
  • after appropriate evaluation, the nausea cannot be fully explained by another medical condition
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13
Q

GERD definiciton

A
  • all individuals who are exposed to the risk of physical complictions form gastro-esophageal reflux
  • or who experine clinically significant impairment of health-related well-being due to reflux related symtpoms
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14
Q

GERD: two main categories

A
  • Patients with ENRD

- patients with esophagitis (with and without complications)

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15
Q

LA classification of esophagitis

A

GRADE A
one (or more) mucosal break, no longer than 5 mm, that does not extend between the tops of two mucosal folds

GRADE B (most common)
- one (or more) mucosal break, more than 5 mm long, that does not extnd between the tops of two mucosal folds

GRADE C
- one (or more) mucosal break that is continuous between the tops of two or mroe mucosal folds, but which involves less than 75% of the circumference

GRADE D
one (or more) mucosal break that involves at least 75% of the esophageal circumference

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16
Q

Heartburn

A
  • primary symtpom of GERD
  • in at least 75% of patients
  • similar in patients with or without esophagitis
17
Q

Chronic cough in GERD

A
  • may be a frequent symptom
  • up to 75% with GERD related cough have no reflux symtpoms
  • may respons to acid suppressive therapy
  • can be caused by acid refluxate entering the lung or stimulating the vagus nerve
18
Q

Causes of incrased exposure of the esophagus to gastric refluxate

A
  • delayed gastric emptying
  • increased intra-abdominal pressure
  • hiatal hernia
  • LES dysfunction
  • Defective esophageal clearance
19
Q

Acid and pepsin in gastric refluxate

A
  • damage esophagus
  • cell junctions widen
  • penetration of acid and pepsin allows contact of acid with nerve endings
  • disrupts intracellular mechanisms leading to cell rupture and damage
20
Q

Lifestyle factors and GERD

A
  • obestiy: only when BMI over 30
  • smoking: lowers LES pressure and the acid-neutralizing effect of saliva
  • Physical activity: running might provoke GERD by increasing TLESRs
21
Q

Dietary factors affecting GERD symtposm

A
  • citrus fruits and juices
  • carbonated drinks
  • caffeine
  • heavy meals
  • fatty and spicy foods
  • alcohol
22
Q

Medications that aggrevate GERD symtpoms

A

Impairment of LES function:

  • beta agonists
  • anticholinergics
  • TCAs
  • Ca blockers
  • alpha antagonsists
  • progesterone

Damage to esophageal mucosa

  • ASS and other NSAIDs
  • tetracycline
  • quinidine
  • bisphosphates
23
Q

Complications of Gerd (esophageal and extraesophageal)

A

ESOPHAGEAL
- metaplasia, malignancy, ulceration, strictures

EXTRAESOPHAGEAL
- movement of gastric refluxate can cause, exacerbate several disorders

24
Q

Barrett’s esophagus

A
  • change in esophageal epithelium of any length and is confuned to have intestinal metaplasia by biopsy of the tubular esophagus
  • squamous epithelium –> columnar epithelium
  • is associated with prolonged acid reflux
25
Q

Barett’s esophagus and adenocarcinoma

A
  • patients with Barrett’s are at increased risk of developing adenocarcinoma
26
Q

Extraesophageal manifestations of GERD

A
  • asthma
  • sinusitis
  • dental erosions
  • reflux laryngitis
  • vocal cord ulcers
  • subglottal/ tracheal stenosis
  • laryngospasm
27
Q

Diagnosis of GERD

A
  • symptom analysis
  • treatment trial with acid-suppressive therapy
  • endoscopy and biopsies Ueosinophilic esophagitis)
  • pH monitoring and electical impendance
28
Q

Treatment trial of acid suppressive therpay in GERD with…

A

PPIs

29
Q

GERD treatment

A
  1. Diet
  2. Emotional - psychological
  3. Alginat4e
  4. Acid reducing medications
    - PPI
    - H2 blockers
    - Antacids
  5. Prokinetics
  6. Surgery
30
Q

Medications in GERD

A
  • Omeprazole and ranitidine in maintaining intraesophageal pH over 4
  • esomeprazole and lansoprazole in healing esophagitis
  • Maintentance of relief from heartburn with esomeprazole and lansoprazole
    Omeprazole and ranitidine in maintaining patients in remission
  • maintenance of esophagitis in long-term remission with esomeprazole or lansoprazole
31
Q

Surgical therapy of GERD

A
  • Nissen fundiplication and the Toupet procedure
32
Q

Endoscopic therapies for GERD

A
  • Stretta procedure

- Gastroplication