Childhood disease III

Question 1

What type of transloaction results in infantile fibrosarcoma?

Answer 1

ETV6-TRKC gene via 12;15 transloaction.

Question 2

What is a tumor marker for congenital infantile fibrosarcoma?

Answer 2

ETV6-TRKC

Question 3

what is the incedence of teratoma?

Answer 3

1/20,000 - 40,000 live births

Question 4

What is the most common solid tumor in the newborn?

Answer 4

acrococcygeal teratoma

Question 5

What is the most common solid congenital malignancy?

Answer 5

Congenital neuroblastoma.

Question 6

What oncogene is associated with neuroblastoma?

Answer 6

N-myc

Question 7

Urine vanillylmandelic acid and homovanillic acid are markers for what condition?

Answer 7

Neuroblastoma.

Question 8

“Small blue round cells with rosette structure and dense core neurosecretory granules”

Answer 8

Neuroblastoma

Question 9

What is most common primary malignant tumor of kidney and what is its incidence?

Answer 9

Wilms tumor with an incidence of 1/10,000

Question 10

Wilms tumor is associated with inactivation of what?

Answer 10

WT1 and WT2

Question 11

Rhabdomyosarccoma

Answer 11

Tends to go to the neck and eyes

accounts for 5-8% malignancy

Question 12

What type of rhabdomyosarcoma is most common?

Answer 12

Embryonal rhabdomyosarcoma 60% followed by:

Alveolar rhabdomyosarcoma
and
Pleomorphic rhabdomyosarcoma (worst)