Childhood bacterial diseases II Flashcards
What is passive immunization?
Transfer of preformed antibody
What is active immunization?
Stimulation of the hosts immune response by the host
What are examples of toxoid vaccines?
Tetanus, Diphtheria, anthrax
Why must the Hib vaccine be conjugated?
Children under 2 don’t recognize T-indepandant antigens like polysaccharides
13-valent pneumococcal and 4-valent meningococcal vaccines are also conjugated
What is the pathogen of whooping cough?
Bordetella pertussis
What are the characteristics of B. pertussis?
Gm-
short coccobacilli
pleomorphic
encapsulated when virulent
What are the virulence factors of B. pertussis?
LPF (lymphocytosis promoting factor) ups cAMP
Extracellular adenylate cyclase - ups cAMP
Filamentous hemagglutinin and pertactin -adhesive
Tracheal cytotoxin-destroys ciliated epithelial cells
During what phase of pertussis is the bacterial culture the highest?
Catarrhal phase
What cough inducing bacteria produces a mercury drop colony when plated?
Pertussis
What is used to treat pertussis?
Erythromycin (or others)
Why might erythromycin fail to improve the condition of a pertussis patient?
Paroxysmal stage my be too late to treat effectively
What is the mechanism of action of the Diptheria toxin?
Inhibits protein synthesis
What are diptheriods?
Corynebacterium diphtheria without the toxin gene from the lysogenic phage
What are the microbe identifying characteristics of C. diphtheriae?
Gm+ Rods
non-motile
non-sporeforming
catalase +
What bacterium forms chinese letters?
Corynebacteria dipthereiae
