Chest Flashcards
Ddx for solitary pulmonary nodule
granuloma, neoplasm, hamartoma, round pneumonia, AVM
Ddx for multiple pulmonary nodules
mets, granulomatous dz (TB or fungal), septic emboli, Wegener granulomatosis
What is Wegener’s granulomatosis?
a multi-system systemic necrotizing non-caeseating granulomatous vasculitis affecting small to medium sized arteries, capillaries and veins 1, and the lungs are the most frequently involved organ, seen in 95% of cases
Appearance of pulmonary Wegener’s?
Highly varied, most commonly nodules +/- cavitation (irregular, thick-walled), hemorrhage, less commonly reticulonodular or peripheral wedge-shaped opacities
Ddx cavitary lung mass
Infxn: TB (reactivation), fungal disease, pulmonary abscess (if widespread, possibly septic emboli)
squamous cell ca,
wegener’s, RA,
Ddx miliary lung nodules
miliary TB, fungal dz, mets (thyroid), pneumoconiosis (silicosis - upper lobe fibrosis/nodules), old varicella, sarcoid
Ddx centrilobular nodules
Infectious bronchiolitis (MAI, TB), hypersensitivity pneumonitis (esp. if gg), endobronchial spread of tumor, RB-ILD (smokers), LCH (early), pneumoconiosis (silicosis or coal-workers’ - look for eggshell LN calcs)
Ddx cystic lung disease
emphysema, LAM (women of reproductive age), pulmonary LCH (smokers: cavitating nodules, irregular, varying sizes), PCP, LIP (peribronchovascular)
post-infectious blebs
Child: hydrocarbons
Ddx lower-lobe predominant ILD
UIP, collagen vascular dz (scleroderma, RA, SLE), asbestos-related lung dz, drug toxicity (eg chemo)
Ddx upper-lobe predominant ILD
postprimary TB, sarcoidosis, CF, pneumoconiosis (silicosis or coal workers’), LCH (smokers)
Ddx hyperlucent lung
chest wall abnl (on x-ray), Swyer-James, acute asthma, airway obstruction, PE (oligemia), bronchial atresia (central mass or nodule, may see mucoid impaction)
What is Swyer-James syndrome?
post-infectious obliterative bronchiolitis, generally characterized on radiographs by a unilateral small lung with hyperlucency and air trapping, CT shows the affected lung as being hyperlucenct with diminished vascularity
Ddx anterior mediastinal mass
Lymphoma, Thymic lesion (thymoma, thymic carcinoma), germ cell neoplasm, (goiter, but usually you can tell it’s from the neck)
Ddx middle mediastinal mass
LAN, vascular abnormality, foregut duplication cyst, pericardial cyst, HH
Ddx posterior mediastinal mass
Neurogenic tumor (neuroblastoma in kids, ganglioneuroma in older), lymphoma, cyst (neurenteric, foregut duplication cyst, extramedullary hematopoiesis
Differences between intralobular and extralobular sequestration
Intralobular has pulmonary venous drainage and tends to get infected. Extralobar has systemic drainage and rarely gets infected
What’s Lemierre syndrome?
Lemierre syndrome refers to rare thrombophlebitis of the jugular veins with distant metastatic sepsis seen in the setting of initial oropharyngeal infection (pharyngitis / tonsillitis +/- peri tonsillar abscess)
reverse batwing sign is likely:
Chronic eosinophilic pna
COP, vasculitis, aspiration, contusion, infarction
Halo sign around lung nodule: most likely? Other possibilities?
Halo is hemorrhage. Classically angioinvasive aspergillosis.
Others: TB, other fungal (mucor, coccidio, crypto), Wegener’s, mets
finger in glove =
allergic bronchopulmonary aspergillosis (ABPA) - overreaction to aspergillus
also bronchial atresia, CF with mucus impaction
crazy paving ddx:
Alveolar proteinosis Sarcoid NSIP Organizing pneumonia (COP) Infection (PCP, viral, Mycoplasma, bacterial) Neoplasm (adeno) Pulmonary hemorrhage Edema (heart failure, ARDS, AIP)
Pulmonary LCH: who? Appearance?
Young (20-40), Hx of SMOKING
Early: small peribronchiolar nodules
Late: multiple irregularly-shaped cysts
mid and upper lung predilection
Bilateral paraspinal masses
extramedullary hematopoeisis, NF, lymphadenopathy
perilymphatic nodules
Sarcoidosis
lymphangitic carcinomatosis from lung ca, met non-lung ca (breast)
silicosis
Atoll sign: aka? ddx?
reverse halo
COP
also regular pna, TB, fungal, Wegener’s, sarcoid
fibrosing mediastinitis: appearance? Caused by? causes what?
Fibrosis/soft tissue in mediastinum. Can compress vessels (SVC, pulmonary), central airways, or esophagus
Causes - mostly idiopathic, also infection (histoplasmosis!), sarcoid, radiation, drugs (methylsergide)
centrilobular ground-glass nodules
Hypersensitivity pneumonitis, atypical infection (PCP, mycoplasma)
Smokers: RB-ILD
mosaic attenuation ddx:
Black is abnl: obstructive small airways disease (asthma, obliterative bronchiolitis in lung transplant rejection, CF)
PE
White is abnl: ground glass (hypersensitivity pna, PCP, eosinophilic PNA, hemorrhage)
appearance of NSIP on CT
patchy, reticulonodular, ground glass, mostly subpleural. Can get some fibrosis in fibrotic subtype
Ddx airspace dz
AIR SPACED
Aspiration, Inhalation, Renal failure (edema), Sarcoid, PNA, Pulmonary hemorrhage, alveolar proteinosis, Collagen Vascular dz, Eosinophilic pna, Drugs
DIseases associated with thymoma:
30% have myasthenia gravis (15% of myasthenia pts have thymoma)
also aplastic anemia, cushing’s disease, hypogammaglobulinemia
Ddx of enlarged pulmonary arteries:
idiopathic/primary
Increased pressures: precap (chronic PE), cap: lung fibrosis/emphysema, postcap: heart stuff (LV failure, mitral stenosis) or Pulmonary veno-occlusive disease (PVOD)
Increased volume: ASD, VSD, AVM, thyrotoxicosis
High flow AND pressure can lead to Eisenmenger’s with reversal of shunt (ASD, VSD, PDA)
Wall prob - vasculitis (Takayasu)
Pulmonary amyloid looks like:
Two subtypes: nodular (diffuse nodules, 50% calcify, 0.5-15cm)
diffuse (interlobular septal thickening, alveolar infiltrates) poor prognosis
ping-pong balls in the chest are called:
Plombage, old way to fill space treating TB
PCP appearance:
ground glass, crazy paving, pneumatoceles in 30%, rarely pleural effusion
Ddx for “tree-in-bud” and what is that
infection (incl TB and atypicals, ABPA), aspiration, diffuse panbronchiolitis, CF, tumor (eg met breast)
Ddx subpleural/peripheral opacities
*Eosinophilic pna (reverse batwing), COP, lymphoma, alveolar sarcoidosis, drugs, NSIP, pulmonary infarct, multifocal pna
Ground glass / ill-defined opacities (not centrilobular nodules)
hypersensitivity pneumonitis, PCP, eosinophilic pna, hemorrhage, DIP (smoker), inhalation injury, adenocarcinoma (Bx if it doesn’t go away on follow-up)
Ddx lower lobe lung fibrosis
UIP, NSIP, asbestosis, CVD (collagen vascular disease)
What’s the name for a cardiac mri sequence when the blood is white and it’s moving?
SSFP cine (steady state free-procession)
Myocardial delayed enhancement - subendocardial:
focal or vascular territory: ischemia
if whole inner surface: amyloid