CHEST Flashcards
- Granuloma - Neoplasm (bronchogenic carcinoima, solitary met) - Hamartoma = Round pneumonia (under 8yo) = AVM
Solitary Pulmonary Nodule
- Mets
- Granulomas (TB or fungal)
- Septic emboli
= Wegener’s
= Rheumatoid
Multiple Pulmonary Nodules
- TB
- Fungal disease
- Sqaumous cell carcinoma
= Pyogenic infection (abscess or septic emboli)
= Wegener’s
= Rheumatoid arthritis
Cavitary Pulmonary Nodule
- TB - Fungal disease - Mets = Pneumoconioses = Healed Varcicella
Milary Pulmonary Nodule
- Infectious bronchiolitis (MAC, TB) - Hypersensitivity pneumonitits - Endobronchial spread of tumor = RB-ILD = Pneumoconioses
Centrilobular Pulmonary Nodules
- Emphysema - LAM - LCH/EG = Pneumocystis pneumonia = LIP
Cystic Lung Disease
- Idiopathic pulmonary fibrosis/UIP - Collagen vascular dz (scleroderma) - Asbestos-related lung dz = drug toxicity
Lower Lobe Interstitial Disease
- TB - Sarcoidosis - Cystic Fibrosis = Pneumoconioses = LCH
Upper Lobe Interstitial Disease
- Chest wall abnormality (Polan, mastectomy) - Swyer-James - Acute asthma = Airway obstruction = PE = Pneumothorax
Hyperlucent Lung
- Lymphoma - Thymic lesion - Thyroid lesion = Germ cell neoplasm (teratoma)
Anterior Mediastinal Mass
- Lymphadenopathy - Vascular abnormality (aneurysm) - Congenital cyst / bronchogenic cyst = hiatal hernia
Middle Medistinal Mass
- Neurogenic tumor - Lymphoma - Developmental cyst (neuroenteric cyst) = extramedullary hematopoiesis = mediastinal hematoma
Posterior Mediastinal Mass
- Cryptogenic Organizing Pneumonia - Pulmonary Alveolar Proteinosis - Bronchioloalveolar Cell Carcinoma [BAC] = Chronic Eosinophilic Pneumonia = Lipoid Pneumonia
Chronic Airspace Disease
- Cryptogenic Organizing Pneumonia - Eosinophilic Pneumonia - Pulmonary Infarction = Pulmonary Contusion = Alveolar Sarcoidosis
Peripheral Airspace Disease
- Pulmonary edema - Atypical infection - Pulmonary hemorrhage = ARDS = Alveolar proteinosis = Vasculitis
Ground Glass Opacification
- Infection - Lymphoma - Sarcoidosis = Mets = Pneumoconioses
Mediastinal/Hilar lymphadenopathy
- Asbestos related pleural disease - Fibrothorax (prior infex or hemorrhage) - Iatrogenic (pleurodesis)
Calcified Pleural Disease
- Postinfectious (bacterial, TB, MAC) - Cystic Fibrosis - ABPA = Obstructive lesion/mass = Ciliary dyskinesia
Bronchiectasis
- Sarcoidosis - Lymphangitic spread of tumor - Pneumoconioses = Lymphoproliferative disorder
Perilymphatic Pulmonary Nodules
- Pleural mets - Empyema - Mesothelioma = Fibrous tumor of the pleura = Fibrothorax
Pleural Based Mass
- PCP - TB - Fungal infection = Invasive aspergillosis = Kaposi Sarcoma = Pulmonary lymphoma
Parenchymal Disease in an HIV patient
- True LV aneurysm - False LV aneurysm - Pericardial cyst/ mass = Calcified pericarditis
Abnormal left ventricular contour
- Thrombus - Mets - Benign Neoplasm (myxoma, rhabdomyoma) = Malignant neoplasm (sarcoma, lymphoma)
Cardiac mass
- Infarction/scar - Myocarditis - Cardiac mass = Infiltrative disease (amyloid, granulomatous)
Delayed myocardial enhancement
- Lipoma - Lipomatous hypertrophy of the interatrial septum - Arrhythmogenic RV dysplasia
Cardiac wall fatty deposit
- Lymphangitic carcinomatosis - lymphoma - sarcoid - pulmonary edema
Unilateral interstitial lung disease
- Histo - Healed varicella - silicosis
Multiple diffuse calcified nodules
- Sarcoid (upper lobe) - EG (upper lobe) - UIP (lower lobe, idiopathic) - Asbestosis (lower lobe) - Pneumoconiosis (upper lobes) - Scleroderma (lower lobe)
Honeycombing
- ABPA (asthmatics) - Noninvasive (normal people, fungus ball) - Semi invasive (mild immunosuppressed) - Invasive (very compromised, ill defined pulm nodules)
4 types of Asprergillus
- PAP - BAC - lipoid pneumonia - Drug induced pneumonitis
Crazy Paving
- COP - sarcoid - BAC - Eosinophilic pneumonia
Peripheral ground glass opacification
- Thymus (thymoma, carcinoma, thymolipoma) 2. Germ cell neoplasm (teratoma) 3. Lymphoma 4. Throid (goiter, cancer) 5. Vascular abnormality (aneurysm)
Anterior Mediastinal Mass
- Infection (fungal, bacterial) 2. Wegener’s ganulomatosis 3. Septic emboli 4. Cavitary Mets 5. Rheumatoid Nodules 6. Pulmonary lacerations
Multiple cavitary lesions
- Edema 2. Hemorrhage 3. Infection (PCP) 4. Hypersensitivity Pneumonitis 5. Drug Toxcicity/Inhalation
Ground Glass Opacities - Acute
- BAC 2. NSIP 3. LIP
Ground Glass Opacities - Chronic
- Neoplasm (squamous, adnoid cystic, mucoepidermoid) 2. Papillomatosis 3. Tracheopathica Osteoplastica 4. Saroidosis, Amyloidosis, Relapsing Polychondritis
Endotracheal mass
- Mesothelioma 2. Pleural Mets 3. Fibrous tumor of pleura 4. Lipoma 5. Empyema/loculated effusion 6. Infection / empyema necessitans
Pleual Mass
- Esophageal injury/rupture 2. Pulmonary/tracheal trauma 3. Rupture of bleb, asthma, severe coughing 4. Barotrauma 5. Surgery 6. Retropharyngeal infection
Pneumomediastinum causes
- UIP / IPF 2. CVD (scleroderma, rheumatoid) 3. Aspiration 4. Asbestosis 5. Durg toxicity (methotrexate, chemo, busulfan)
Basilar Fibrosis
- Sarcoidosis 2. Lymphoma 3. Mets 4. Small cell lung cancer 5. Infections (TB) 6. Castleman’s Dz
Bilateral hilar adenonopathy
- Miliary TB / Histo 2. Hematogenous mets (thyroid, renal) 3. Silicosis 4. EG
Small nodules, random distribution
- Neruogenic tumor (schwannoma, neurofibroma, paraganglioma, ganglioneuroma) 2. Hematoma 3. Abscess (Pott’s dz) 4. Vascular (aortic aneurysm) 5. Extramedullary hematopoesis
Posterior Mediastial Mass
- Cystic Fibrosis 2. Kartagener’s / Ciliary Dyskinesia 3. Chronic aspiration 4. Chroinic infection 5. Inhalation injury
Bronchiectasis
- Maligancy (primary and mets) 2. Hamartoma 3. AVM 4. Infection 5. Fluid/effusion 6. Round atelectasis (a/w asbestos exposure)
Solitary Lung Mass
- Esophagus (mass, tic, hiatal hernia) 2. Varicies 3. Foregut cyst 4. Lymphadenopathy 5. Pericardial mass/ cyst 6. LV pseudoanerysm 7. Aortic or PA aneurysm
Middle Mediastinal Mass
- Edema 2. Hemorrhage / Contusion 3. Infection 4. Drug toxicity 5. Hypersensitivity Pneumontis
Bilateral Patchy Opacities - Acute
- BAC 2. Sarcoidosis 3. COP / BOOP 4. Eosinophilic Pneumonia 5. PAP 6. NSIP
Bilateral Patchy Opacities - Non-Acute
- Azygous continuation of IVC - Obstruction of vena cava - Tricuspid insufficiency - Rt sided heart failure
Causes of azygous vein enlargement
- Pulmonary embolism - Extrinsic compression of PA (mass, aortic aneurysm [Ehlor-Danlos, Marfan’s, syphilis]) - Aortic dissection
Causes of unilateral absent perfusion on VQ scan
- silicosis - sarcoidosis - Coal worker’s pneumoconisosis - ankylosing spondylitis - EG - cystic fibrosis
Upper Lung Chronic Infiltrative Disease
- Cystic medial necrosis (marfan’s, Ehlers-Danlos) - atherosclerosis - syphilis
Causes of ascending aortic aneurysms [>4cm]
- kidney - melanoma - thyroid - breast - colon
Common extrathoracic sites with endobronchial mets
- radiation fibrosis - mediastinal lipomatosis - vascular abnormalites (coarc)
Bilaterally enlarged apical caps
- Bronchogenic carcinoma - lymphoma - extrapleural hematoma - abscess - radiation fibrosis
Unilateral apical cap
Cryptococcus
In an HIV + patient, what fungal infection presents with pulmonary nodules, pleural effusion, and lymph node enlargement?
- maligancy - cystic fibrosis - IPF - localized fibrous lesions of the pleura
Disorders that are associated with Hypertrophic Pulmonary Osteoarthropathy
Cylindrical Varicoid Cystic/Saccular
Three types of bronchiectasis (Reid classification)
Cystic Fibrosis Williams-Campbell Immotile cilia syndrome Mounier-Kuhn Primary hypogammaglobulinemia
Congenital disorders associated with bronchiectasis
- Loffler’s syndrome - Chronic eosinophilic pneumonia - BOOP - pulmonary infarcts - vasculitides
Peripheral distribution of consolidation
- centrilobular 2. paraseptal 3. panlobular 4. paracicatricial
4 types of emphysema
Alpha-1-antitrypsin Ritalin lung IV methylphenidate
Panlobular emphysema with basilar predominance
- mosaic perfusion - bronchial dilation - air trapping
CT findings of bronchiolitis obliterans
- bone marrow txplant - viral infections - toxic inhalation - rheumatoid arthritis - lung txplant - IBD
Conditions associated with bronchilitis obliterans
- curvilinear subpleural lines 2. thickened septal lines 3. subpleural dependent density 4. parenchymal bands 5. honeycombing
5 CT findings of asbestosis
ground glass opacification with smooth septal thickening in a geographic distribution
Define crazy paving
- BOOP - Loffler’s syndrome - chronic eosinophilic pneumonia - pulmonary infarcts - vasculitidies
Peripheral pattern of consilidation
- Left to right shunt (Vein of Galen, hemangioendothelioma) - Coarctation - Hypoplastic left heart - narrow proximal Aorta, MV, and LV - Arrhythmia - Cardiomyopathy
CHF in a newborn
- Hypersensitivity pneumonitis - Sarcoid - Acute on chronic PE - GVHD/CVD (BO and OP)
Head Cheese (air trapping, normal lung, GGO)
Think small airways disease - BO - Asthma
Mosaic Attenuation with air traping
- Chronic PE (pulmonary HTN and enlarged RVH) - Vasculitis - Fibrosing mediastinitis (ST around aorta, RVH, RVE)
Mosaic attenuation with no air trapping
- TOF - Ebsteins - Severe pulmonary stenosis - Tricuspid atresia
Neonate with CHD with decreased pulmonary vascularity
- D-transposition - Truncus arteriosis - TAPVR - VSD - ASD - PDA
Neonate with CHD and increased pulmonary vascularity
- hypoplastic L heart - coarcation - ?TAPVR
Neonate with CHD and pulmonary venous HTN
- Neurogenic - ARDS - Near drowning - Re-expansion pulmonary edema - Acute inhalational injury
Noncardiogenic edema
- Pericardial effusion - oreo cookie sign - Bicuspid aortic valve, aortic stenosis - Coarctation - figure of 3 sign, rib notching (ddx NF) - Extrathoracic shunt - Vein of galen, hemangioendothelioma - Cardiomyopathy - infiltrating (sarcoid,amyloid,HOCM) - Cardiomyopathy - ischemic/infarction - Kawasaki - coronary artery aneurysms - Cor tritriatrium
Acyanotic, no shunt vascularity, big heart, +/- edema
Obstructive, Relaxation, Adhesive, Cicatricial
Types of Atelectasis
Crescent of air on frontal CXR, interface between aorta and hyperexpanded superior segment of LLL
Luftsichel sign
Diffuse cysts , round in shape, thin walled, diffuse, female childbearing age, assoc with tuberous sclerosis 1%
Lymphangiomyomatosis findings and association
RUL atelectasis, usually due to obstructing mass
Golden’s S sign
LLL atelectasis with downward shift of hilar structures causing flattening of left heart border and cardiac rotation
Flat waist sign
1) abnormal adjacent pleura (effusion or pleural thickening/plaque); 2) peripheral, touching pleura; 3) round or elliptical; 4) volume loss in lobe; 5) comet tail sign (pulmonary vessels and bronchi leading to opacity)
Signs of round atelectasis
Pneumonia (atypical in GGO such as viral or PJP) Pulmonary hemorrhage/edema ARDS
Ddx of acute consolidation/GGO
-Mucinous adenocarcinoma -Organizing pneumonia -Chronic eosinophilic pneumonia GGO add Idiopathic pneumonia Hypersensitivity pneumonitis Alveolar proteinosis
Ddx of chronic consolidation/GGO
Pulmonary hemorrhage Pulmonary edema - cardiogenic PJP Alveolar proteinosis
Ddx of GGO in central distribution
Organizing pneumonia Chronic eosinophilic pneumonia Atypical pneumonia Pulmonary edema - noncardiogenic
DDx for peripheral consolidation/GGO
Smooth - pulmonary edema/hemorrhage, Alveolar proteinosis, Atypical pneumonia Nodular - Sarcoid, lymphangitic carcinomatosis
Interlobular septal thickening types and ddx
Alveolar proteinosis PJP Organizing pneumonia Mucinous adenocarcinoma Lipoid pneumonia ARDS Pulmonary hemorrhage
Ddx for crazy paving
Subpleural sparing –Infectious - endobronchial TB or MAI, bronchopneumonia, atypical PNA –Inflammatory - HSP, RB-ILD, diffuse panbronchiolitis, silicosis, hot tub lung (rxn to atypical mycobacterium like HSP)
Ddx of Centrilobular pulmonary nodules
Sarcoid Pneumoconiosis Lymphangitic carcinomatosis
Ddx of perilymphatic nodules
Fungal Miliary TB
Interstitial lung disease, nodules, acute
Silicosis Sarcoidosis LCH Lymphangitic carcinomatosis
Interstitial lung disease, nodular, chronic
Silicosis Sarcoid Treated lymphoma
Eggshell calcifications in lungs
Interstitial edema Atypical pneumonia (viral, PJP)
Interstitial,lung disease, reticular, acute
Fibrosis Emphysema Cystic lung dz Bronchiectasis
Interstitial lung disease, reticular, chronic
Sarcoid Chronic HSP Cystic fibrosis Prior TB Ankylosing spondylitis XRT Silicosis
Fibrosis, upper lobe distribution
UIP, NSIP Connective tissue disorders with UIP-like findings Chronic aspiration End stage asbestosis
Fibrosis, lower lobe distribution
Lymphangitic carcinomatosis Lymphoma Kaposi’s sarcoma Amyloid - rare
Interstitial lung disease, septal lines, chronic
Pulmonary edema Atypical infections
Interstitial lung disease, septal lines, acute (Kerley B lines)
Mycobacterium TB or atypical mycobacterium, bacterial or aspiration pneumonia, airway invasive aspergillus
Tree in bud nodules
Hematogenous metasteses, septic emboli, pulmonary LCH
Random nodules
Disseminated TB, fungal or hematogenous mets
Miliary nodules
Solitary - primary bronchogenic carcinoma (cavitary adenocarcinoma or squamous cell), TB (upper lobe) Multiple - septic emboli, vasculitis, mets (squamous cell or uterine)
Cavitary lesion, solitary and multiple
Solitary - bulla, bleb, pneumatocoele Multiple - lymphangiomyomatosis, emphysema, pulmonary LCH, diffuse cystic Bronchiectasis, PJP pneumonia, lymphoid interstitial pneumonia
Lung cysts , solitary and multiple
Ground glass attenuation surrounding consolidation. Ddx angioinvasive aspegillosis, hemorrhage met, Wegeners granulomatosis, Kaposi’s sarcoma, viral infection
Halo sign in pulmonary
Relapsing polychondritis - usu involves ears and nose in middle age female Tracheobrochopathi osteochondroplastica - nodular with calcifications
Tracheal thickening, diffuse, sparing of posterior trachea
TB - smooth long segment Amyloid - nodular +/- calcifications Wegeners granulomatosis - subglottic stenosis Sarcoid - hilar LAD, differing presentations
Tracheal thickening, diffuse, circumferential
Apical, posterior, anterior
RUL segments?
Lateral and medial
RML segments?
Superior, Lateral, Anterior, Posterior, Medial
RLL and LLL segments?
Apical posterior. Anterior. Superior lingula. Inferior lingula.
LUL segments.
**In lower lobes, medial and anterior are anterior, posterior and lateral are posterior
RUL from RML. Fine horizontal line.
Minor fissure?
1%. RUL apical or posterior segments are encased in their own parietal and visceral pleura
Azygos lobe?
Subsegmental atelectasis. Dont see them in obstructive atelectasis because airways are obstructed of course.
In which type of atelectasis would you expect to see air bronchograms?
Obstruction of small peripheral bronchi usually due to secretions
Subsegmental atelectasis?
**Obstructive atelectasis happens more quickly in patients breathing supplemental oxygen because its absorbed from the alveoli quicker than nitrogen. Obstructive atelectasis happens when oxygen from air is absorbed by blood and not replaced.
**In general obstructive atelectasis is associated with volume loss, but in critically ill ICU patients, there may be rapid transudation of fluid into obstructed alveoli, causing superimposed consolidation
This is what is seen adjacent to a mass or pleural effusion causing mass effect
Relaxation atlectasis?
Lack of surfactant. RDS. ARDS.
Adhesive atelectasis?
Volume loss from architectural distortion of lung parenchyma by fibrosis
Cicatrical atelectasis?
Mucus plugging
Acute lobar atelectasis?
Obstructing central tumor must be ruled out
Lobar atelectasis in an outpatient?
Luftsichel sign. Crescent of air on the frontal radiograph representing the interface between the aorta and the hyperexpanded superior segment of LLL
What sign in LUL atelectasis?
Reverse S sign of Golden.
Sign in RUL collapse?
Peridiaphragmatic triangular opacity caused by diaphragmatic traction from an inferior accessory fissure or an inferior pulmonary ligament
Juxtraphrenic peak sign?
Heart rotates and the L hilum is pulled down.
What do you see in LLL collapse?
Flat waist sign describes flattening of the L heart border as a result of downward shift of hilar structures
What sign in LLL collapse?
**RLL collapse is a mirror image of LLL collapse
You may only seen loss of R heart border.
RML atelectasis?
Focal atelectasis with a round morphology, always associated with an adjacent pleural abnormality
Round atelectasis?
All five have to met. Adjacent pleura has to be abnormal. Opacity must be peripheral and in contact with pleura. Must be round or elliptical. Volume loss in affected lobe. Pulmonary vessels and bronchi leading into the opacity must be curved causing comet tail
Diagnostic criteria for round atelectasis?
Centrilobular artery and central bronchus.
Center of each secondary pulmonary lobule?
Pulmonary veins and lymphatics
Periphery of each pulmonary lobule?
Between 1-2.5 cm
Size of SPL?
**Only call ground glass on CT
Complete filling of the affected alveoli with a liquidlike substance- Blood, pus, water, or cells
Histology of consolidation?
**Can’t see pulmonary vessels through the consolidatoin on unenhnaced CT, but you can with ground glass opacification (GGO)
Pneumonia. Pulmonary Hemorrhage. ARDS. Pulmonary edema.
Differenential of acute consolidation?
BAC. Organizing pneumonia. Chronic eosinophilic pneumonia.
Differential of chronic consolidation?
Upper lobes
Distribution of chronic eosinophilic pneumonia?
Incomplete filling of alveoli (blood, pus, water, or cells). Alveolar wall thickneing, or reduced aeration.
Histology of ground glass opacification?
Edema. Pna (Atypical more common). Pulm hemorrhage. ARDS.
Differential of acute GGO?
BAC. Organizing pneumonia. Chronic eosinophilic pneumonia. Idiopathic pneumonias. HP (subacute phase). Alveolar proteinosis.
Chronic GGO differential?
Edema. Alveolar hemorrhage. Pneumocystis Jiroveci. Alveolar proteinosis.
Central distribution of GGO?
Organizing pna. Chronic eosinophilic (upper lobes). Atypical or viral pna. Edema (noncardiac, cardiac will be central)
Peripheral consolidation or GGO?
Edema
By far, most common cause of smooth interlobular septal thickening?
Edema. PAP. Pulm hemorrhage. Atypical pna. (Same diff as central GGO)
Diff for smooth interlobular septal thickening?
Lymphangitic carcinomatosis. Sarcoidosis.
Nodular, irregular, or assymetric septal thickening?
Interlobular septal thickening with superimposed GGO
Crazy paving?
Filling of alveoli with proeinaceous material and septal thickening caused by lymphatics taking up the same material
Why does PAP cause crazy paving?
PAP. Pneumocystic Jiroveci. Organizing pna. BAC (mucinous). Lipoid pneumonia. ARDS. Pulm Hemorrhage.
Differential for crazy paving? (7)
**Centrilobular nodules never extend to the pleural surface
Endobronchial spread of TB or atypical mycobacteria. Bronchonpneumonia. Atypical pneumonia (esp. mycoplasma)
Infectious causes of centrilobular nodules?
HSP and RB ILD are most common. Otehrwise Hot tub lung, diffuse panbronchiolitis, and silicosis.
Inflammatory causes of centrilobular nodules?
Chronic inflammatory disorder characterized by lymphoid hyperplasia of the walls of respiratory bronchioles, usually patients are Asian.
Diffuse panbronchiolitis?
Type III
What type of hypersensitivity reaction is HSP?
Subpleural. Peribronchovascular. Septal.
Three locations of perilymphatic nodules?
Sarcoid.
Most common cause of perilymphatic nodules?
Sarcoid. Confluent perilymphatic nodules.
Galaxy sign?
Pneumoconioses and lymphangitic carcinomatosis.
Other causes of perilymphatic nodules?
Mets. Septic emboli. Pulmonary LCH.
Random nodule distribution?
Diseminated TB. Diseminated fungal infection. Diseminated mets.
Miliary pattern of nodules?
**Most effusions associated with pneumonia are not empyemas but instead are a sterile effusion caused by increaed capillary permeability
**Treatment of BPF is very contraversial and individualized
**Miliary TB can be primary or reactivation TB
**Normal CT rules out P Jiroveci but it can hide in a normal chest radiograph
Impacted bronchioles, nodules are the impacted terminal bronchioles.
What are the linear branching structures in the tree in bud pattern? The nodules?
Small airways infection
Tree in bud are almost always associated with what?
Mycobacteria. Bacterial pna. Aspiration pna. Airway invasive aspergillosis
Diff for tree in bud nodules?
Under 4 mm will be benign and over 15 mm will be malignant
Wall thickness for definite benign or malignant cavitary lesions?
Cancer or infection
Solitary cavitary lesion is almost always what?
Carcinoma (SCC or adno, usually SCC). TB (Upper lobe cavitation). Septic emboli. Vasculitis (Wegeners). Metastases.
Diff for cavitary lesions?
LAM. Emphysema (upper lobe in a smoker). Pulmonary LCH (cysts and nodules in upper lungs). Diffuse cystic bronchiectasis. Pneumocystis jiroveci. LIP
Diff for multiple lung cysts?
Bulla is big, larger than 1 cm, occupies at least 30% of volume of the thorax. Bleb is an air filled structure contiguous with pleura less than 1 cm
Bulla vs bleb?
IPF. End stage asbestosis. NSIP.
Diff for lower lobe fibrotic changes?
Collagen vascular disease or drug reaction.
NSIP usually associated with what?
Cellular and fibrotic.
Two types of NSIP?
NO
Honeycombing in NSIP?
Fibrotic
Which type of NSIP causes basilar fibrosis?
End stage sarcoidosis. Chronic hypersensitivity pneumonitis. End stage silicosis.
Upper lobe firbosis differential?
Mycoplasma. Viral. Chlamydia.
Types of pneumonia which affect young otherwise healthy patients?
Elderly smokers. Severe infections
Who gets legionella?
Alcoholics and aspirators
Who gets klebsiella?
Voluminous inflammatory exudates causing the bulging fissure sign.
Klebsiella leads to what?
MRSA and resistent gram negatives including pseudomonas
Most important pathogens in HAP?
Usually polymicrobial but pseudomonas and acinetobacter are useful
Pathogens in VAP?
Patchy consolidation with poorly defined airspace opacities usually involving several lobes. Usually S Aureus.
What is bronchopneumonia?
Inflammatory cells in the interstitial tissues of the alveolar septa. Atypical agents.
Interstitial pneumonia?
Children. Incomplete pohrs of Kohn. S. Pneumonia.
What causes round pneumonia?
Necrosis or sloughing of a pulmonary segment or lobe, severe manifestation of pulmonary abscess.
Pulmonary gangrene?
1- Free flowing exudative effusion- treat with needle aspiration or simple drain. 2- Development of fibrous strands- Large bore chest tube and fibrinolytic therapy. 3- Fluid becomes solid and jelly like- Requires surgery.
3 Stages of Empyema?
**Most effusions associated with pneumonia are not empyemas but instead are a sterile effusion caused by increaed capillary permeability
Surgery. More rare causes are lung abscess, empyemia, trauma.
Most common cause of bronchopleural fistula?
New or increasing gas in a pleural effusion.
Imaging of BPF?
**Treatment of BPF is very contraversial and individualized
Extension of empyema to chest wall, usually due to TB. Can also be caused by Nocardia and Actinomyces
Empyema necessitans?
Contained disease. Primary TB.
Initial exposure to TB can lead to what two clinical outcomes?
90%. Results in calcified granulomas and/or calcified hilar lymph nodes. Normal immune patients will sequester the bacilli with a caseating granuloma.
Describe contained TB?
Host cannot contain the organism- Seen in immunocompromised and children
Describe primary TB?
15%
What percentage of primary TB have normal radiographs?
Ill defined consolidation. Pleural effusion. Lymphadenopathy. Miliary disease.
4 Imaging features of pulmonary primary TB?
Lower lobes and RML.
Most common lobes for primary TB?
Initial focus of parenchymal infection.
Ghon Focus?
Ghon focus and lymphadenopathy
Ranke complex?
Rare in primary TB. Common in reactivation TB.
Which TB gets cavitation?
Low attenuation centrally and peripheral enhancement.
Adeonpathy in TB?
Primary. Rare in post primary.
Which TB gets adenopathy?
Upper lobe apical and posterior segments.
Where does reactivation TB usually occur?
Cavitation and lack of adenopathy. Focal upper lobe consolidation and endobronchial spread (Tree in bud) is common.
Reactivation TB in an immunocompetent patient?
Low attenuation adenopathy. May mimic immune reconstitution syndrome seen in HIV patients.
Reactivation TB in an immunocompromised patient?
Well defined rounded opacity in the upper lobes
Tuberculoma?
Apical scarring with upper lobe volume loss and superior hilar retraction.
Healed TB?
Containment of initial infection by a delayed hypersensitivity response.
Calcified granulomas signify what?
**Miliary TB can be primary or reactivation TB
Bronchiectasis and tree in bud nodules in the RML or lingula.
Classic radiographic findings of Lady Windermere syndrome?
Elderly woman with cough, low grade fever and weight loss
Clinical presentation of Lady Windermere syndrome?
MAI. M. Kansasii
Organisms in Lady Windermere syndrome?
Hypersensitivity pneumonitis in response to atypical mycobacteria which are often found in hot tubs. Patient is otherwise healthy, no active infection. Imaging is similar to other causes of HP with centrilobular nodules.
What is hot tub lung?
Fibrosing mediastinitis, infection of lymph nodes leading to pulmonary venous obstruction, bronchial stenosis, and pulmonary artery stenosis.
Rare complication of histoplasmosis?
TB- Upper lobe fibrocavitary consolidation
Chronic histoplasmosis can mimic what?
Bacterial pna. Consider TB if CD4 count is low.
Focal airspace opacity in an immunocompromised patient?
CD4 less than 200
Who gets pneumocystic jiroveci?
Bilateral perihilar airspace opacities with peripheral sparing.
Classic radiographic findings of P Jiroveci?
Perihilar GGO sometimes with crazy paving.
Classic CT of P Jiroveci?
**Normal CT rules out P Jiroveci but it can hide in a normal chest radiograph
Upper lobe pneumotoceles which may predispose to pneumothorax or pneumomediastinum.
P Jiroveci has a propensity to lead to what?
Cryptococcus
Most common fungal infection in AIDS patients?
Cryptococcus meningitis
Pulmonary infection with cryptococcus usually coexists with what?
Less than 100
CD4 in cryptococcus?
Wide range: GGO, Focal consolidation, cavitating nodules, miliary diseaes, lymphadenopathy, effusions
Imaging of cryptococcus?
Individuals with abnormal immunity or pre-existing pulmonary disease
Aspergillus only affects who?
ABPA, Aspergilloma (Saprophytic), Semi invasive. Airway invasive. Angioinvasive.
Types of aspergillus infection?
Hypersensitivity reaction to aspergillus in patients with long standing asthma
What is allergic bronchopulmonary aspergillosis and who gets it?
Recurrent wheezing, low grade fever, cough, sputum production. Sputum contains fragments of aspergillus hyphae.
Presentation of ABPA?
Upper lobe bronchiectasis and mucoid impaction which can be high attenuation or even calcified
Key finding on CT of ABPA?
Finger in glove
Combination of mucoid impaction within bronchiectatic airways represents what sign?
An aspergilloma develops in a pre-existing cavity.
What is saprophytic aspergillosis?
**Imaging of patient in different positions causes the aspergilloma to move
TB and sarcoid.
Most common causes of a pre-existing cavity?
Hemoptysis
Most common symptom of aspergilloma?
Crescent of air outlines the mycetoma against the wall of the cavity.
Monod sign?
Necrotizing granulomatous inflammation (analogous in pathology to reactivation tb) in response to chronic aspergillus infection.
What is semi-invasive aspergillosis?
Debilated, diabetic, alcoholic, and COPD patients
Who gets semi-invasive aspergillosis?
Segmental areas of consolidation, often with cavitatoin and pleural thickening, which progress slowly over months or years
CT of semi-invasive aspergillosis?
Infection deep to the airway epithelial cells
What is airway invasive aspergillosis?
Only the immunocompromised, including neutropenic and AIDS patients
Who gets airway invasive aspergillosis?
From bronchiolitis to bronchopneumonia
Spectrum of clinical disease in airway invasive aspergillosis?
Centrilobular and tree in bud nodules. Also bronchopneumonia which is indistinguishable from other causes of bronchopneumonia
CT findings of airway invasive aspergillosis?
Aggressive infection characterized by invasion and occlusion of arterioles and smaller pulmonary arteries by fungal hyphae.
What is angioinvasive aspergillosis?
Severely immunocompromised patients, including patients on chemotherapy, stem cell or solid organ trasplant recipients, and in AIDS
Who gets angioinvasive aspergillosis?
Represents a crescent of air from retraction of infarcted lung. Good prognostic sign indicating patient is in recovery phase.
Air cresent sign in angioinvasive aspergillosis?
Dilated lymphatic channels radiating from hila, clinically insignificant
What do Kerley A lines represent?
Radiate from periphery- Thickened interlobular septa
Kerley B lines?
Vascular redistribution (increased caliber of the upper lobe vessels compared to lower lobe vessels). Interstitial edema. Alveolar edema (Pleural effusions and cardimegaly are usually present)
3 stages of pulmonary edema radiographically?
Intrathoracic- Patchy. Nonthoracic- Diffuse.
GGO in intrathoracic causes of edema vs non thoracic causes?
Aggressive thoracentesis- reexpansion of lung in a state of collapse for more than 3 days
When does reexpasion pulmonary edema occur?
Transverse width of the upper mediastinum
Vascular pedicle?
Interface of the SVC and R mainstem bronchus.
Right border of vascular pedicle?
Lateral border of the takeoff of the subclavian from the aorta
L border of the vascular pedicle?
Less than 58 mm
Normal vascular pedicle width?
**Vascular pedicle widths of 63 and 70 have been proposed as cutoffs for increased pulmonary capillary wedge pressure
**ET Tube can be slightly lower in situations with low pulmonary compliance like ARDS to reduce barotrauma
1% of patients. Increased risk of venous perforation and thrombosis
Look at pics of azygous malposition of catheter, what risks? What percentage of patients have azygous malposition.
Rupture or pseudoanerysm. Also intracardiac catheter knot and arrythmias are other complications of swan ganz catheters
Risks of Swan Ganz distal to proximal interlobar pulmonary artery? General risks of Swan Ganz.
80-90%
Tobacco is thought to cause what percentage of lung cancers?
**Asbestos increases lung ca risk by 5 and is synergistic with smoking
**Pulmonary fibrosis increases lung ca risk by 10
**Scarring also increases risk
GG nodule
More likely malignant, solid or gg nodule?
Central. Laminar. Diffuse.
What types of calcification are benign?
Hamartoma
What nodules have popcorn calcification?
Non round is usually benign
Shape of pulmonary nodule and correlation with ca?
Infection
Clustering of nodules suggests?
18% of malignancy.
Nodule .8-3cm?
Very high chance of malignancy
Nodules over 3 cm?
Irregular edge or spiculated margin
Margins which are concerning?
26%
Doubling in volume corresponds to what increase in diameter?
**Decrease in size of a suspicious nodule isn’t sufficient to diagnose benignity, can occur with collpase of aerated alveoli or necrosis
Small cell
Histology of lung ca with the worst prognosis?
Adneocarcinoma
Most common histological subtype of lung ca?
Peripheral
Adenocarcinoma, central or peripheral?
TTF-1 (Thyroid transcription factor). Positive in adenocarcinoma and negative in pulmonary mets
Pathologic marker of adenocarcinoma of the lung?
Main lobar or segmental bronchi. Causes symptoms early due to bronchial obstruction.
Majority of SCC arise from where?
BAC. Spreading of malignant cells using the alveolar walls as a scaffold
Lepidic growth?
Most other types of lung cancer. Cancer growth by invasion and destruction of lung parenchyma.
Hilic growth?
Negative
BAC on PET?
**New classification of BAC- Going to ignore this
Nonmucinous
Better prognosis, nonmucinous or mucinous BAC?
Solid or gg nodule with air bronchograms
Imaging of nonmucinous BAC?
Chronic consolidation.
Imaging of mucinous BAC?
Describes prominent appearance of enhancing pulmonary vessels seen in low attenuation mucin rich consolidation of mucinous BAC
CT angiogram sign?
Small cell (after adeno and scc)
Third most common histologic subypte of lung cancer?
Neuroendocrine
In small cells, neoplastic cells are of what origin?
Smoking
Small cell associated with what?
Central bronchi with invasion through the bronchial wall, typically presenting as a large hilar or perihilar mass.
Where dose small cell tend to occur?
**Small cell is considered disemminated disease, rarely amenable to surgery
**Large cell is a wastebasket diagnosis for tumors which aren’t squamous, adenocarcinoma, or small cell
Smoking
Large cell associated with what?
Periphery as a large mass
Where do large cell carcinomas usually occur?
Endobronchial mass distal to the carina which may cause obstructive atelectasis. Up to 20% of cases present as a pulmonary nodule
Common presentation of carcnoid?
Typical- without mets has an excellent prognosis (92% survival over 5 years). Atypical has a worse prognosis and arises in periphery.
Describe two subtypes of carcinoid?
DIPNECH- Extremely uncommon precursor lesion to typical carcinoid tumor, characterized by mutiple foci of neurondocrine hyperplasia or tumorlets (Carcinoid foci less than 5 mm) and bronchiolitis obliterans
What is diffuse idiopathic pulmonary neuroendocrine cell hyperplasia?
Adenocarcinoma, including BAC
50% of cancrs presenting as a solitary pulmonary nodule is what?
SCC and Small cell
Hilar mass is a common presentation of which lung cancers?
**Tapered bronchus is highly specific for lung cancer
Lung ca occuring in the lung apex
What is a superior sulcus tumor?
Type of superior sulcus tumor with involvement of the sympathetic ganglia causing Horner syndrome
What is a pancoast tumor?
Ipsilateral ptosis, miosis, anhidrosis
Horner syndrome?
T3
What stage is a superior sulcus tumor?
Diffuse spread of neoplasm through the pulmonary lymphatics, typically seen in late stage disease. Nodular interlobular septal thickening, usually asymmetric
What is lymphangitic carcinomatosis?
M1a- meaning it precludes curative resection. Have to do cytologic evaluation to be sure.
What stage is a malignant effusion?
Early stages up to IIB and sometimes IIIA. Can do neoadjuvant or adjuvant chemo and radiotherapy also.
Surgery is performed for what stages of lung cancer?
Contralteral or supraclavicular lymph nodes.
What makes a tumor IIIb or unresectable?
**Skipped lung cancer staging. Probably need to review later?
WHO Class 1 entities
When can you use pulmonary arterial hypertension instead of pulmonary hypertension?
Pulmonary arterial systolic pressure greater than 25 at rest or 30 during exercise.
Definition of pulmonary arterial hypertension?
When pulmonary capillary wedge pressure is greater than 18
When are elevated pulmonary venous pressures present?
Chronic thromboembolic disease, chronic respiratory disease, chronic heart disease, idipathic causes
Causes of pulmonary hypertension?
Pre-capillary and Post-capillary.
Most common classification of pulmonary hypertension?
Causes clear up to the pulmonary parenchyma.
Precapillary is what?
Problems with pulmonary veins or pulmonary venous pressure.
Postcapillary is what?
Pulmonary arterial hypertension. Pulmonary venous hypertension. Pulmonary hypertension associated with chronic hypoxemia. Pulmonary hypertension due to thromboembolic disease. Pulmonary hypertension due to miscellaneous disorders.
5 classes of pulmonary hypertension according to WHO?
Primary (Idiopathic or familial). Congenital L to R shunts. Pulmonary venous or capillary involvement such as pulmonary venoocclusive disease and pulmonary capillary hemangiomatosis
Causes of grade 1 pulmonary hypertension?
L sided heart disease.
Causes of grade 2 pulmonary hypertension?
Sarcoid, compression of vessels, etc.
Causes of grade 5 pulmonary hypertension?
Pulmonary artery calcifications
Pathognominic for pulmonary artery hypertension?
Mosaic attenuation due to perfusion abnormalities
Lungs in pulmonary hypertension?
Confirms that a hilar mass is in fact a pulmonary artery. There is a convergence of hilar pulmonary artery branches into an enlarged pulmonary artery
Hilum convergence sign?
Visualization of hilar vessels thorugh a mass- indicates that a mass is actually present.
Hilum overlay sign?
Anterior mediastinum, never middle.
Where is mass in hilum overlay sign?
Enlarged centrally. Taper distally.
Imaging of pulmonary arteries in pulmonary hypertension?
In wall of muscular arteries in pulmonary hypertension- Focal disruption of the elastic lamina by an obstructing plexus of endothelial channels. Relative paucity of prostacyclins and nitric oxide expressed by endothelial cells
Plexiform lesion?
Fibrotic obliteration of the pulmonary veins and venules.
Pulmonary veno-occlusive disease?
May be idiopathic but is associated with pregnancy, drugs, and bone marrow transplant
Associations of pulmonary veno-occlusive disease?
Pulmonary arterial enlargement. Pulmonary edema and gg centrilobular nodules are often present
Imaging of pulmonary veno-occlusive disease?
Surgical thromboendartectomy (similar to carotid endarterectomy)
Treatment of chronic thromboembolic pulmonary hypertension?
Histoplasmosis and TB
Most common cause of fibrosing mediastinitis?
Increased mediastinal soft tissue often with calcified lymph nodes due to prior granulomatous infection
Imaging of fibrosing mediastinitis?
Widening of pulmonary arteries due to clot
Fleishner sign?
Peripheral wedge shaped opacity representing pulmonary infarct.
Hamptoms hump?
Regional oligemia in lung distal to pulmonary artery thrombus
Westermark sign?
Form alveolar wall and participate in gas exchange
Type 1 pneumocytes?
Produce surfactant, which prevents atelectasis
Type 2 pneumocytes?
2-4 years
Mean survival of interstitial pulmonary fibrosis
AIP
Only interstitial pneumonia with a worse prognosis than pulmonary fibrosis?
IPF
Clinical syndrome of UIP?
Collagen vascular disease (RA more than scleroderma). Drug injury. Asbestosis.
Other triggers of lung injury that may result in a UIP pattern?
Less fibrotic change in NSIP
NSIP vs UIP histology
NSIP responds to steroids
Treatment difference between NSIP and UIP?
NSIP
Most common pulmonary manifestation in patients with collagen vascular disase?
Ground glass opacities, nearly always bilateral
Important imaging feature of NSIP?
Features GGO with fine reticulation and traction bronchiectasis
Fibrotic NSIP appearance?
Fibrotic
Which NSIP has worse prognosis?
GGO without much fibrotic changes
Cellular NSIP appearance?
Fibrotic
Which NSIP is more common?
Sparing of immediate subpleural lung
Very specific but uncommon finding in NSIP?
Cryptogenic organizing pneumonia- Clinical syndrome of organizing pneumonia without known cause
What is COP?
**COP used to be called BOOP
Responds to steroids with a good prognosis, may resolve completely, although recurrences are common
Treatment and prognosis of COP?
Granulation tissue polyps that fill the distal airway and alveoli
Pathologic pattern of OP?
Mixed consolidation and ground glass opacities in a peripheral and peribronchovascular distribution
CT of OP?
Reverse halo or Atoll sign- Central lucency surrounded by a GG halo
What sign is specific for COP?
Halo sign- Invasive aspergillus
Central opacity with peripheral GG?
Smoking
RB-ILD associated with what?
Pigmented macrophages are found in respiratory bronchioles
Pathological finding in RB-ILD?
Centrilobular nodules and patchy GGO.
Key imaging findings of RB-ILD?
More random in RB-ILD where it is more peripheral in NSIP
Distribution of GGO in RB-ILD vs NSIP?
**RB-ILD and DIP represent a continous spectrum of smoking related lung disease
In DIP, the brown pigmented macrophages also extend into the alveoli
Pathology of RB-ILD vs DIP?
Diffuse basal predominant patchy or subpleural GGO, more extensive than RB-ILD. A few cysts may also be present although predominant abnormality is GGO
Imaging of DIP?
Sjogrens, HIV
LIP is very rare, associated with what?
DIffuse infiltration of the interstitium by lymphocytes and other immune cells, with resultant distortion of the avleoli.
Histology of LIP?
Diffuse or lower lobe predominant GGO with scattered thin walled perivascular cysts, thought to be due to air trapping from peribronchiolar cellular debris
Imaging of LIP?
PTX
LIP may be complicated by what in advanced disease?
DAD- Diffuse alveolar damage.
AIP is synonomous with what?
Clinical syndrome of ARDS
What is AIP?
Surfactant destruction
Primary cause of AIP?
Early (Exudative) and chronic (Organizing)
Two phases of AIP?
Acute, subacute, chronic
Phases of HP?
Inflammatory exudate filling the alveoli, manifests on imaging as groundglass or consolidation. Small, ill defined centrilobular nodules.
Acute HP?
Centrilobular GG nodules. Mosaic attenuation
Subacute HP?
Describes combination of patchy GG and areas of lucency due to mosaic perfusion or air trapping
Head cheese sign?
**Abnormalities of HP involve entire axial cross section of lung
Upper lobe predominant pulmonary fibrosis superimposed on findings of subacute and acute HP
Chronic HP?
Can be seen in upper lobes but is uncommon.
Honeycombing in HP?
Pneumoconiosis is due to inorganic dust inhalation where HP is organic dust inhalation
Pneumoconioses vs HP?
Silicosis and coal workers pneumoconiosis
Two most common pneumoconioses?
**Findings of CWP and Silicosis are indistinguishable
Miners, from inhalation of silica dust
Who gets silicosis?
Inhalation of coal dust
CWP is due to what?
Upper lobe predominant centilobular and subpleural nodules
Most characteristic finding of uncomplicated disease in silicosis and CWP?
Silicosis. Less commonly CWP
Eggshell lymph node calcifications?
Large conglomerate masses (Progressive massive fibrosis)
Complications of silicosis or CWP?
TB
Both silicosis and CWP have increased risk of?
RA and either CWP (more common) or silicosis- represents necrobiotic rheumatoid nodules superimposed on the smaller centrilobualr and subleural nodules of the pneumoconiosis.
Caplan syndrome?
Pulmonary fibrosis with a UIP pathology
End stage asbestosis?
Lower lobes, the asbestos fibers are too large to be removed by the alveolar macrophages and lymphatic system
Upper or lower lobes for asbestosis? Why?
Pleural thickening and plaques (May or may not be calcified).
Clue to asbestos exposure?
**Even though pleural plaques are due to asbestos exposure, they are not a component of asbestosis, do not lead to fibrosis, and are usually asymptomatic
**Eosinophilic lung disease is a spectrum of diseases that feature accumulation of eosinophils in the pulmonary airspaces and interstitium
Also called Loeffler syndrome- Transient and migratory areas of focal consolidation, with an elevated eosinophilic count in the peripheral smear
Simple pulmonary eosinophilia?
**Identical appearance to eosinophilia can be seen with parasites and drugs but simple pulmonary eosinophilia is reserved for idiopathic causes
Peripheral with upper lobe predominance- pattern can remain unchanged for months.
Consolidation in chronic eosinophlic pneumonia?
Steroids- Responds rapidly
Treatment of chronic eosinophilic pneumonia?
Systemic small vessel disease associated with asthma and peripheral eosinophilia
Churg Strauss?
p ANCA
What is positive in Churg Strauss?
Varied, most common appearance is peripheral consolidation or GG
Imaging findings of Churg Strauss?
p ANCA. Most common cuase of pulmonary hemorrhage with renal failure
Microscopic polyangiitis is most common cause of what? What is positive?
Cnetral predominant GG representing hemorrhage
Imaging of microscopic polyangiitis?
Sinusitis, lung involvement, and renal insufficiency
Triad of Wegeners?
c ANCA
Lab tests specific for Wegeners?
Nasopharyngeal and eustachian tube obstruction. Involvement of trachea and bronchi is common, leading to airway stenosis
Upper airways in Wegeners?
Multiple cavitary nodules which don’t respond to abx. Intra-cavitary fluid level suggests superimposed infection
Lungs in Wegeners? Superimposed infection?
**Drugs can elicit numerous pulmonary responses
40%
What percentage of patients develop radiographic abnormalities after external radiotherapy?
Early stage of radiation injury, can occur within one month of radiotherapy, most severe 3-4 months after treatment. GG centered on radiation port, but can extend out of radiation port
Radiation pneumonitis?
Late stage of radiation injury. Fibrosis becomes apparent 6-12 months after therapy. Key imaging finding is distribution of fibrosis and traction bronchiectasis within the radiation port, but may extend out of the port
Radiation fibrosis?
Pulmonary fibrosis with honeycombing, slight upper lobe predominance
Pulmonary sarcoidosis may progress to what in lungs?
Radiographs only- 0 Normal radiograph. 1- Hilar or mediastinal adenopathy only. 2- Adenopathy with lung changes 3- Lung w/o adenopathy. 4- Endstage fibrosis
Staging of sarcoid?
Symmetric addenopathy with stippled or egg shell calcification in up to 50%
Most common radiographic finding in sarcoid?
Right paratracheal, R hilar, L hilar- Completely encircles trachea on lateral- donut sign
Where is adenopathy in sarcoid?
Upper lobe predominant perilymphatic nodules of variable sizes representing sarcoid granulomas
In addition to lymphadenopathy, most common ct finding in sarcoid?
May see superimposed GGO in sarcoid
Mosaic perfusion due to air trapping
Bronchial involvement of sarcoid?
Smoking- Nearly 100% association
Pulmonary LCH associated with?
PTX
How may pumonary LCH present?
Diabetes insipidus from inflammation of pituitary stalk (hypophysitis), lucent bone lesions, skin involvement.
What other associated findings may be seen with pulmonary LCH?
LCH. Malignancy. TB. Fungal. Sarcoid. Gaucher.
Differential for dz affecting bone and lung?
Rare, but may resemple DIP
Gaucher in lungs?
Nodules associated with airways, as they progress they will cavitate and resultant irregular cysts predominate
First detectable abnormality and progression in LCH?
Smoking cessation is critical. Responds to steroids.
Treatment of pulmonary LCH?
Upper lobe predominant cysts and irregular peribronchovascular nodules both sparing the costophrenic sulci
So overall findings in LCH?
In PAP, there are no effusions and the heart is normal in size
PAP vs pulmonary edema?
Superimposed infection, especially with nocardia
Patients with PAP are susceptible to what?
Bronchialveolar lavage
Treatment of PAP?
1%
What percentage of TS patients have LAM?
Women of child-bearing age
Almost all cases of sporadic LAM are in what patients?
Estrogen
Some cases of LAM respond to what?
PTX, Chylous effusion
LAM is associated with what two things?
Cysts are round and regular and affect all five lobes where LCH is just upper lobe
Cysts in LAM vs LCH?
Prevascular superiorly and precardiac inferiorly (Precardiac is only a potential space)
Two compartments in anterior mediastinum?
**Bascially all of the mediastinal structures are in the middle mediastinum including the phrenic, vagus, and recurrent laryngeal nerve
Posterior trachea and posterior pericardium
Anterior border of the posterior mediastinum?
Formed by four laters of pleura at the anterior junction of the R and L lungs. Projections over the superior 2/3 of the sternum.
Anterior junction line?
Anterior mediastinal mass
Abnormal convexity or displacement of the anterior junction line?
Four layers of pleura, seen projection through the trachea on frontal view, more superior than the anterior junction line.
Posterior junction line?
Posterior
Which extend more superiorly, posterior or anterior lungs?
Posterior mediastinal mass
Abnormal convexity or displacement of the posterior junction line?
Formed by two layers of pleura where the medial aspect of each lung abuts the lateral wall of the trachea and intervening mediastinal fat
Right and Left paratracheal stripes?
Usually pleural thickening, although a paratracheal or tracheal mass can be the cause
Thickening of the R paratracheal stripe?
Same diff as on the R except add mediastinal hematoma in setting of trauma
Thickening of the L paratracheal stripe?
Only interface seen on lateral view, representing interface of posterior wall of trachea with two pleural layers of the medial right lung
Posterior tracheal stripe?
Mach effect
Why do we see R and L paraspinal lines?
2 layers of pleura abutting the posterior mediastinum
What forms the paraspinal lines?
Posterior mediastinal mass
Paraspinal line abnormality?
Interface formed by contact of the posteromedial RLL and retrocardiac mediastinum. Extends from the subcarinal region to the diaphragm inferiorly
Azygoesophageal recess?
Esophageal mass, hiatal hernia, L atrial enlargement and adenopathy
Distortion of the azygoesophageal recess?
Lymph nodes (most common cause of AP abnormality). L Phrenic nerve. Recurrent laryngeal nerve. L vagus nerve. Ligamentum arteriosum. L bronchial arteries
What lives in the AP window?
Anterior mediastinal mass, RV dilatation, Pulmonary artery enlargement
Obliteration of the retrosternal clear space?
Emphysema
Increase in retrosternal clear space?
From the L superior intercostal vein, not usually seen on radiography. It may be dilated in SVC obstruction as a collateral.
Aortic nipple?
Normal posterior junction line because ant junction line isn’t always seen
Easiest way to infer an anterior mediastinal mass on cxr?
Thymic epithelial neoplasm. Germ cell tumor. Thyroid lesion if it extends above thoracic inlet. Lymphoma.
Anterior mediastinal mass diff dx?
Thymoma. Middle aged to older individuals, 45-60.
Most common primary tumor of the anterior mediastinum? Who gets it?
33%. 10%
What percentage of thymoma patients have MG? Other way around.
MG. Red cell aplasia. Hypogammaglobulinemia. Paraneoplastic syndromes. Malignancies such as lymphoma and thyroid cancer.
Thymomas are associated with what other diseases?
Whether capsule is intact
Invasive and non invasive thymoma?
30%. May invade adjacent structures.
What percentage of thymomas are invasive?
Phrenic nerve invasion
Thymoma with L hemidiaphragm elevation?
Drop mets along pleural and pericardial surfaces. Hematogenous mets are very rare.
Where does invasive thymoma spread?
**Thymomas are classfied into A, AB, B1, B2, B3, C, with C being the worst
Thymic carcinoma. Thymic carcinoid. Thymic cyst. Thymolipoma.
Other less common thymic lesions?
Histologically malignant. Aggressive. Hematogenous mets. Poor prognosis.
Thymic carcinoma characteristics?
Metastatic pattern.
Distinguishing between thymic carcinoma and thymoma on CT?
ACTH, causing Cushing syndrome
50% of thymic carcinoids secrete and cause what?
MEN 1 and 2
Thymic carcinoid is associated with what?
Indistinguishable from thymoma and thymic carcinoma.
Imaging of thymic carcinoid?
Preoperative Indium 111 Octreotide.
If carcinoid is suspected, what imaging?
Radiation therapy, AIDS, Congenital
Thymic cyst often caused by what?
Remnants of the thymopharyngeal duct
When thymic cysts are congenital they arise from what?
Anterior mediastinum
Congenital thymic cyst may occur anywhere along the descent of the course of the thymus from neck but usually occur where?
Benign fat containing lesion with interspersed soft tissue. Can become really large and drape over the mediastinum.
Characteristics of a thymolipoma?
Males
Malignant germ cell tumor- which gender?
Fat fluid level. Not commonly seen.
What is specific for a teratoma?
Teratoma
Most common anterior mediastinal germ cell tumor?
**Aorta is in posterior mediastinum, posterior mediastinal mass would silhouette the aorta
Seminoma
What is most common malignant mediastinal germ cell tumor?
Obscuration of the superior border of the mass implying mass is in continuity with the soft tissues of the neck
Cervicothoracic sign?
Continuity with the superior thyroid obviously
Key to diagnosing a thyroid lesion as an anterior mediastinal mass?
**Calcification is rare in untreated lymphoma.
Hodgkins
Lymphoma most commonly in thorax?
Usually happens in CWP and silicosis. Less commonly in sarcoid, but sarcoid is more common.
Egg shell calcification?
TB. Can also be seen in fungal infection, metastatic disease and sometimes lymphoma
Low attenuation lymph nodes should raise concern for what?
Castleman disease. Sarcoid. TB. Vascular mets.
Avid lymph node enhancement?
Angiofollicular lymph node hyperplasia- cause of highly vascular thoracic lymph node enlargement, uncertain etiology.
What is castleman disease?
Children. Surgical resection.
Who gets localized Castlemen and what is cure?
Older patients or AIDS patients.
Who gets multicentric Castleman disease?
Systemic illness including fever, anemia, lymphoma. Treat with chemo.
Symptoms of multicentric Castlemans? Treatment?
Avidly enhancing lymphadenopathy
Key imaging feature of Castemans?
R cardiophrenic angle. Cystic lesion abuts pericardium, can change shape.
Most common location of pericardial cyst? Appearnce.