Chemotherapy MoAs

Question 1

Abiraterone (Zytiga) MoA

Answer 1

Works by inhibiting 17-a hydroxylase therefore lowering testosterone precursor synthesis of DHEA and androstenedione

Question 2

Cabozantinib (Cometriq) MoA

Answer 2

TK inhibitor of AXL, FLT-3, KIT, MER, MET, RET, ROS, VEGFR-1,2,3; used in clear cell renal carcinomas

Question 3

Sunitinib MoA

Answer 3

RTK that inhibits VEGF 123, PDGFR-aB, KIT, FLT-3, RET, CSF-1r, which disrupts angiogensis, tumor signaling and promotes apoptosis

Question 4

Daratumumab MoA

Answer 4

IgG1k ab directed against CD38 which is a surface antigen highly expressed on myeloma cells and lower on regular myeloid/lymphoid cells

Induces apoptosis by Fc cross linking and immune mediated tumor lysis through complement and antibody dependent cytotoxicity

Question 5

Carfilzomib (Krypolis) MoA

Answer 5

Inhibits proteosome 20s inducing cell apoptosis by pausing the cell cylce

Question 6

Cyclophosphamide MoA

Answer 6

Prevents cell division by cross-linking DNA strands and decreasing DNA synthesis; cell cycle nonspecific

Prodrug that is activated in the liver

Question 7

Ixazomib (Ninlaro) MoA

Answer 7

Reversible 20s proteosome inhibitor leading to cell cycle arrest and apoptosis (like Krypolis/Carilzomib)

Is an oral medication that is taken for maintenance as well

Question 8

Lenalidomide (Revlimid) MoA

Answer 8

Inhibits secretion of pro-inflammatory cytokines (TNF-a), enhances cell-mediated immunity (increased IL-2 and IFN-y secretion), and inhibits tropic factors in angiogenic cells

Question 9

Pomalidomide (Pomalyst) MoA

Answer 9

Induces cell cycle arrest and apoptosis in MM cells by enhancing NK-cell mediated immunity, TNF-a,IL-1, IL-6 (all proinflammatory) and angiogenesis