Chemotherapy Flashcards

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1
Q

How do alkylating agents work?

A
  • impair DNA replication
  • example: platinum compounds
  • platinated inter- and intrastrand adducts leads to inhibition of DNA synthesis
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2
Q

How do anti-metabolites (methotrexate and 5-Flurouracil) work?

A
  • fluorouracil activates thymidylate synthase which damages DNA
  • methotrexate inhibits a critical point in the folate cycle; therefore no purines can be formed
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3
Q

How do spindle poisons work?

A
  • affect the spindle fibres during the mitosis cycle in metaphase and anaphase
  • inhibits polymerization
  • or stimulates polymerization and prevents depolymerization
  • the taxoids promote assembly and prevent disassembly, so the spindles become so rigid that division cannot occur properly
  • the vinca alkaloids prevent spindle formation
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