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Microbiology Mina > Chemotherapy > Flashcards

Chemotherapy Flashcards

1
Q

Cell membrane inhibitors

A 
TIPP
Triazoles
Imidazole 
Polyenes; fungi
Polymyxins; gram-
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2
Q

Protein synthesis inhibitors

A 
Line takes Anton's Mac for chemistry 
Lincosamides
Tetracycline
Aminoglycosides 
Macrolides 
Fusidic acid 
Chloramphenicol
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3
Q

Nucelic acid synthesis inhibitors

A

Quinn’s rifle fires three souls. Quinn smokes cigars and pipes. This happens during the nuclear wear.

Quinolone; ciprofloxacin, pipemidic acid
Rifamycin; rifampin
Fusidic acid
Trimethoprim 
Sulfonamide
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4
Q

B-lactamase inhibitors

A

When lactating, children sucks on your Tatars.
Clavulanic acid
Sulbactam
Tazobactam

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5
Q

Antileprotic drugs

A 
Mina cyclet under klar himmel, hun treffer på et reef... Uflax! Klo fast i Mine, Dapsoone.
Minocycline
Clarithromycin
Rifampicin
Ofloxacine
Clofazimine
Dapsoone
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6
Q

Bactericidal

A 
Kills bacteria
MBC, minimal bactericidal concentration. 
AB(...cde)FG
Aminoglycosides - cons.dep
B-lactams - time dep.
Fluroquionolones - cons.dep
Glycopeptides
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7
Q

Bacterostatic

A

Inhibits bacterial growth
MIC: time above
Good efficiency: b-lactams and macrolides
AUC, area under curve; azythromycine

Lincosamides
Chloramphenicol
Macrolides
Tetracycline
Ketolides 
Sulfonamides
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8
Q

Penicillins

A

Cell wall

High affinity for B-lactams

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9
Q

Cell wall synthesis inhibitors

A

B-lactames; penicillin, cephalosporins
Polypeptides; bacitracin
Glycopeptides; teicoplanin, daptomycin, vancomycin
Fosfomycin

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10
Q

Penicillins, natural + bacteria

A

Benzylpenicillin G
Phenoxymethylpenicillin V

Strep+staph, Takes a trip to Nigeria Close to Benin

Streptococcus spp. penicillianse (-)
Staphylococcus spp. 
Treponema
Neisseria
Clostridium 
Bacillus
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11
Q

Penicillins, semisynthetic + bacteria

A 
Isoxazolyl penicillins: 
Drugs: meth, coke, fluor
Methycillin
Cloxacillin
Dicloxacillin
Flucloxacillin
  • Staph +&-
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12
Q

Penicillins with broad spect.

Aminopenicillins

A 
Aminopenicillins: 
- Ampicillin
- Amoxycillin
Like penicillin G 
Staph+strep takes a trip to Nigeria close to Benin +
HELME: 
Haemophulus
Enterococcus
Listeria 
Moraxella 
Enterobacteriacae
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13
Q

Penicillins with broad spect.

Carboxy-, ureido

A 
Piper likes Carbs like Macaroni, Tikka, Aioli
-Piperacillion
-Carbapenem
-Mezlocillin
-Azlocillin
-Ticarcillin
\+
Acinetobacter
Pseudomonas
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14
Q

Penicillins with broad spect.

With inhibitors of B-lactamases

A

Ampicillin/sulbactam
Amoxycillin/clavulanic acid
Ticaracilin/clavulanic azid
Piperacilin/tazobactam

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15
Q

4 groups of penicillins

A
  1. Highest act against G+, spirochetes - suspectible to hydrolysis by B-lactamases and acid-lable.
    Penicillin G
  2. Lower act against G+, inactive G-, relative resistance to B-lactamases.
    Nafcillin
  3. High act against G+ and G-, destroyded by B-lactamases.
    Ampicillin, piperacillin
  4. Stable to gastric acid, oral adm.
    Penicillin V, cloxacillin, amoxicillin
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16
Q

Cefalosporins

- activity

A

Inactive: Enterococcus, listeria, MRSA, most anaerobes.
Penetrate CNS
Good tolerance
Susceptibility to B-lactamases

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17
Q

Cefalosporins

I. gen

A 
Cefalotin
Cefazolin
Cefradine
Cefadroxyl
Cefalexin
Strep(+), staph
PEK
Proteus
E.coli
Klebsiella
18
Q

Cefalosporins

II.gen

A 
Cefaclor
Cefuroxim
Cefamandol
Cefprozil
\+
Haeomphilus
Moraxella+
19
Q

Cefalosporins

III.gen

A 
More resistant to B-lactamases
Penetrate into CNS
Cefotaxime
Cetriaxone
Ceftazidime
Cefoperazon
\+
Acinetobacter
Pseudomonas

Orally: inactive against pseudomonas, less active staph.

20
Q

Cefalosporins

IV.gen

A

More active to staph
More resistant to B-l
Cefepime
Cefpirome

21
Q

Cefalosporins

V. gen

A

Ceftaroline
Anti-MRSA

Seff tar ho Line MRSA

22
Q

Monobactams

A 
Aztreonam
G(-) aerobes
Haeomphilus
Neisseria
G(-) rods
23
Q

Carbapenems

A 
spiser du Erter må du Mer Inni Do
Ertapenem
Meropenem
Imipenem
Doripenems

Highest act G+/- aerobes, anaerobes, enterococci.

INACTIVE: 
MRSA, 
Jeikeium
Faecium
Burkholderia
Stenotrophomonas
24
Q

Bacterostatic 50S

Spectrum

A

Ketolides
Azalides
Macrolides

Atypical bacteria:
Chlamydia
Mycoplasma
Legionella
Ureaplasma
Rikettsia

Side effects:
Nausea
Vomiting
Diarrhoea

25
Q 
Bacterostatic 50S
14 member (macrocyclic lactone)
A 
Trec
Telithromycin (ketolide)
Roxythromycin
Erythromycin
Clarithromycin
26
Q

Bacterostatic 50S

15 member

A

Azalide - Azithromycine

27
Q

17-member

A

Spiramycin

28
Q

Lincosamides

A

Lincomycin
Clindamycin

Disturbance of gut flora -> Clostridium difficile

29
Q

Streptogramines A, B

A 
Active against 
MRSA
PRSP
VISA
VRE
Enterococcus faecium
30
Q

Bactericidal 30S
Aminoglycosides
Natural

A

Neo er en gente som sitter i en kana, blir bitt av en tobra og får strepto

Neomycin
Gentamycin
Kanamycin
Tobramycin
Streptomycin
31
Q

Bactericidal 30S
Aminoglycosides
Semisynthetic

A

Fake Natila = Netila
Annika = Amika

Netilmicin
Amikacin

32
Q

Bactericidal 30S
Aminoglycosides
Spectrum

A 
G(-) rods, except Haemophilus
Inactive with penicillin
Strepto
Entero
\+ Anaerobes

Disadv.
No absorption from GIT
Nephro and otoxic
PAE

33
Q

PAE

A

Carbapenemes with G- bacilli

34
Q

Linezolid

A 
Synthetic
Aerobic G+
Inhibits protein synthesis
Bacterostatic: enterococci + staph
Bacterocidal: strepto
35
Q

Tigecyclin

A

Inhibits protein translatiojn
Generally bacterostatic
Bacterocidal against S.pneumoniae
L.pneumophila

36
Q

Atypical bacteria

A 
Mycoplasma
Rickettsias
Legionella
Chlamydia
Ureaplasma 
(Haemophilus)
37
Q

Antibiotics against atypical bacteria

A

Lincon betaler en penny for å ta metro med sin tiger. Den spiser carbs, altså maccaroni ceff.

Lincosamide
Penicillin
Metroniadazole
Tygacycline
Carbapenem
Macrolides
Cefalosporins
38
Q

First-line antituberculous drugs

A

Reis Roma(med buti)-Paris

Rifampin (orange urine, sweat, tears)
Ethambutol
Isoniazid
Streptomycin
Rifabutin
Pyrazinamide
39
Q

Second-line antituberculous drugs

A

Fecck Pavel og Viola

Fluroquionolones
Ethionamide
Caperomycin
Cycloserine
Paraaminosalycilic
Viomycin
40
Q

Triple antileprotic

A 
Dapsone
Rifampin
Clofazimine
- Severe: min. 2 years
- Less severe: rifampin + dapsone for 6 months

Microbiology Mina (9 decks)

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