Chemotherapy Flashcards
Radiosensitizer
Doxorubicin (Adriamycin)
Can cause Cardiac Toxicity
Cisplatin
Can cause hearing loss, nephrotoxicity
Radioprotector
Amifostine
Bleomycin
Can cause Pulmonary Toxicity
Vinka Alkaloids (Mitotic Inhibitors)
Periwinkle Plant
Terminates Cell Replication in Metaphase
Topoisomerase Inhibitors
Plant Alkaloid
Interferes with Enzymes (topoismerases) to stop replication
Hormonal Agents
Replaces natural hormones
Anti-Tumor Antibiotics
Hinders transcription of DNA & RNA
Antimetabolites
5-FU
Disturbs the formation of new Nucleic Acids
Cell Cycle Specific
Nitrosoureas
Group of Alkylating Agents
Hinders the Synthesis of DNA
Can cross BBB (lipid soluble)
Alkylating Agents
Chemically similar to Mustard Gas