Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Cancer care > Chemotherapy > Flashcards

Chemotherapy Flashcards

1
Q

What is an example of an alkylating agent?

A

Cyclophosphamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How do alkylating agents work?

A

Causes cross lining in DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are some adverse effects of cyclophosphamide?

A

Haemorrhagic cystitis, myelosupression, transitional cell carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are examples of cytotoxic antibiotics?

A

Bleomycin, anthracyclines (e.g doxorubicin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the main adverse defect of bleomycin to be aware of?

A

Lung fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the main adverse effect of doxorubicin to be aware of?

A

Cardiomyopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is meant by the term neoadjuvant?

A

Administration of a therapeutic agent before definitive treatment to shrink tumour and optimise outcomes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is meant by the term adjuvant?

A

Treatment given after definitive treatment to reduce the risk of disease recurrence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is meant by the term palliative cancer therapy?

A

Treatment designed to relieve symptoms and improve quality of life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the different classes of chemotherapeutic agents?

A

Alkylating agents, taxanes, vinka alkaloids, platinum complexes, anti metabolites, anthracyclines, anti tumour antibiotics, topoisomerase inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are examples of taxanes?

A

Paclitaxel, docetaxel, cabazitaxel

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How do taxanes work?

A

Bins to microtubules which inhibits anaphase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are adverse effects of taxanes?

A

Alopecia, peripheral neuropathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are examples of vinka alkaloids?

A

Vincristine, vinorelbine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the main adverse effect of vinka alkaloids?

A

Peripheral neuropathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How do vinka alkaloids work?

A

They inhibit microtubules resulting in failure of mitotic spindles

17
Q

What are examples of platinums?

A

Cisplatin, carboplatin, oxaliplatin

18
Q

What are the effects of platinums toxicity?

A

Highly emetogenic, ototoxicity, nephrotoxicity, peripheral neuropathy

19
Q

How do platinums work?

A

They cause cross linking of DNA strands and stop DNA replication

20
Q

What are examples of anti metabolites?

A

5FU, capecitabine, methotrexate, gemcitabine, pemetrexed

21
Q

What are the adverse effects of anti-metabolites?

A

Palmar plantar erythema, diarrhoea, mucositis

22
Q

what would bilateral ground glass appearance on chest Xray/CT?

A

atypical infection like PCP

23
Q
A

Cancer care (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions