Chemotherapies Flashcards

1
Q

What is the mechanism of action for alkylating agents?

A

Act directly on DNA to ultimately prevent cell division and cause cell death

Cross link DNA strands to prevent replication

Abnormal base pairing and DNA strand breaks

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2
Q

What are six types of alkylating agents?

A

Alkylsulfonates

Ethylenimines

Hydrazines and Triazines

Metal salts

Mustard gas derivatives

Nitrosureas

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3
Q

What is the mechanism of action for antimetabolites?

A

Structural analogs of naturally occuring metabolites that compete for catalytic or regulatory site of key enzyme.

Can also be substituted and incorporated into DNA and RNA

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4
Q

What are five types of antimetabolites?

A

Purine antagonists

Pyrimidine antagonists

Folate analogs

Adenosine analogs

Substituted ureas

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5
Q

What is the mechanism of action for topoisomerase inhibitors?

A

Inhibit or interfere with topoisomerase enzymes I and II

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6
Q

What are types of topoisomerase I inhibitors?

A

Irinotecan

Topotecan

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7
Q

What are types of topoisomerase II inhibitors?

A

Amsacrine

Etoposide

Teniposide

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8
Q

What is the mechanism of action for Anti-microtubule agents?

A

Block the ability of a cancer cell to divide via kinetic stabilization of microtubule dynamics

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9
Q

What are types of anti-microtubule agents?

A

Vinca alkaloids

Taxanes

Podophyllaotoxins

Camptothecin analogs

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10
Q

What is the mechanism of action for antitumor antibiotics?

A

Intercalate into DNa and prevent RNA synthesis

Maximal toxicity in S phase

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11
Q

What are types of antitumor antibiotics?

A

Anthracyclines

Chromomycins

Mitomycin and Bleomycin

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12
Q

What is the mechanism of action for monoclonal antibodies?

A

Attenuate hyperactive growth signals

Create immune response

Inhibit angiogenesis

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13
Q

What are the cell cycle specific drugs?

A

Antimetabolites

Topoisomerase I inhibitors

Antimicrotubule agents

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14
Q

Which drugs are not cell cycle specific?

A

Alkylating agents

Topoisomerase II inhibitors

Antitumor antibiotics

Monoclonal antibodies

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