Chemotherapeutics

Question 1

ALL txt?

Answer 1

1. methotrexate 2. 6-mercaptopurine 3. cyclophosphamide 4. vincristine 5. daunorubicin or COMBO: vincristine + prednisone + one other agent–remember: ALL is in KIDS so KIDS believe mercaptains;

Question 2

AML

Answer 2

Cytarabine–very effective on its own–think Cyanara AML

Cytarabine and Idarubicin–Ciara and Ida treat AML

after remission–still need to keep saying cyanara so more Cytarabine and HSC`

Question 3

CML

Answer 3

Imatinib

Dasa–DASA BAAAAD CML–for overcoming resistance

Bulsulfan

Question 4

CLL

Answer 4

COP: Cyclophosphamide + Vincristine (brand name starts with O) + Prednisone

CHOP: Cyclophosphamide + Doxorubicin (H brand name) + Vincristine (brand name starts with O) + Prednisone

the COP karate CHOPPED the CLL by BENDING his hands

Bendamustine

Chlorambucil

Fludarabine–FLUD the lungs with PCP (side effect)

Question 5

Hodgkin’s Lymphoma

Answer 5

Stage 1 and Stage 11a: ABVD

Stage 3 and 4: ABVD or Stanford V or MOPP

Question 6

what makes up ABVD

Answer 6

A–anthracycline doxorubicin, B–bleomycin, V–vinblastine D–dacarbazine–get in the CAR Hodgkin

Question 7

Non-Hodgkin’s lymphoma

Answer 7

CHOP–Cyclophosphamide+ Doxorubicin (H) + Vincristine (O) + Prednisone

karate CHOP by bending your knees

Bendamustine

Question 8

Multiple Myeloma

Answer 8

Melphalan–mel’s phalanges got multiple myeloma

Question 9

Breast Cancer

Answer 9

stage 1–surgical

stage 2–CMF–Cyclophosphamide + methotrexate + 5FU and FAC–5FU + anthracycline (doxorubicin) + cyclophosphamide

Question 10

prostrate CA

Answer 10

docetaxel+prednisone–standard of care–MEN WEAR DOCKERS–DOCETAXEL
mitoxantrone+prednisone–palliation for bone pain

Question 11

colorectal CA

Answer 11

FOLFOX–folinic acid (leucovorin) +5FU+oxaliplatin–oxes with their stomachs and their poop–good for colon CA

XELOX–XE is the capecitabine–cafecita–coffee makes you poop OX–oxaliplatin–oxes with their poop

Question 12

Colorectal CA that has metastasized

Answer 12

FOLFIRI: folinic acid (leucovorin) +5FU + Irinotcan–which gives you diarrhea cause of the toucan and fruit loops–so good for colon CA ADD: ziv-aflibercept if progressing

FOLFOX or FOLFIRI+bevacizumab

Question 13

refractory colon CA

Answer 13

TAS 102–slap TAT ASS

Question 14

NSCLC standard option

Answer 14

Bevacizumab–take a BEVERAGE since your cup IS NOT SMALL—NON SMALL CELL

Question 15

Squamous Histo Lung CA

Answer 15

Cisplatin (or carboplatin) + Cetuximab or + gemcitabine +necitumumab

Question 16

refractory Squamous Cell Lung CA

Answer 16

Nivolumab–finding NIVO–finding NEMO was hard so this is for when the cancer gets really hard

Question 17

NSCLC maintenance therapy

Answer 17

pemetrexed after 4 cycles of platinum based chemo

Question 18

NSCLC with L858R exon 19 or 12 mutations that has advanced

Answer 18

Erlotinib–you advance when you’re an Earl of someplace

Question 19

NSNSCLC with L858R exon 19 or 12 mutations that has metastasized

Answer 19

Afatinib–you’re a fatty now cause of metastasis (I know so wrong)

Question 20

Small Cell Lung CA

Answer 20

Cisplatin + either etoposide or irinotecan–just remember topoisomerase 2 for etoposide and topoisomerase 1 for irinotecan

Question 21

Small Cell Lung CA that failed initial therapy

Answer 21

Topotecan

Question 22

Ovarian CA stage 1

Answer 22

Cisplatin + Cyclophosphamide

Question 23

Ovarian CA stage 3 and 4

Answer 23

Carboplatin + Paclitaxel

Question 24

Testicular Cancer

Answer 24

Penises Eat Boobs–Platinum (cisplatin) , Etoposide, Bleomycin

Question 25

Malignant Melanoma with BRAF V600E whats the most active cytoxic agents?

Answer 25

Dacarbazine or cisplatin

Question 26

Malignant Melanoma with BRAF V600E what if it is unresectable or metastatic

Answer 26

Nivolumab–remember finding NIMO is so hard–for unresectable CA and Pembrolizumab

Question 27

Brain Cancer monotherapy what single agent?

Answer 27

Carmustine

Question 28

Oligodendroglioma regime of choice

Answer 28

PCV–procarbazine + CCNU (lomustine) + vincristine

Question 29

Adult Glioblastoma–monotherapy or combo therapy

Answer 29

bevacizumab–take a beverage to drink with for your brain B and B