Chemotherapeutics Flashcards
ALL txt?
- methotrexate 2. 6-mercaptopurine 3. cyclophosphamide 4. vincristine 5. daunorubicin or COMBO: vincristine + prednisone + one other agent–remember: ALL is in KIDS so KIDS believe mercaptains;
AML
Cytarabine–very effective on its own–think Cyanara AML
Cytarabine and Idarubicin–Ciara and Ida treat AML
after remission–still need to keep saying cyanara so more Cytarabine and HSC`
CML
Imatinib
Dasa–DASA BAAAAD CML–for overcoming resistance
Bulsulfan
CLL
COP: Cyclophosphamide + Vincristine (brand name starts with O) + Prednisone
CHOP: Cyclophosphamide + Doxorubicin (H brand name) + Vincristine (brand name starts with O) + Prednisone
the COP karate CHOPPED the CLL by BENDING his hands
Bendamustine
Chlorambucil
Fludarabine–FLUD the lungs with PCP (side effect)
Hodgkin’s Lymphoma
Stage 1 and Stage 11a: ABVD
Stage 3 and 4: ABVD or Stanford V or MOPP
what makes up ABVD
A–anthracycline doxorubicin, B–bleomycin, V–vinblastine D–dacarbazine–get in the CAR Hodgkin
Non-Hodgkin’s lymphoma
CHOP–Cyclophosphamide+ Doxorubicin (H) + Vincristine (O) + Prednisone
karate CHOP by bending your knees
Bendamustine
Multiple Myeloma
Melphalan–mel’s phalanges got multiple myeloma
Breast Cancer
stage 1–surgical
stage 2–CMF–Cyclophosphamide + methotrexate + 5FU and FAC–5FU + anthracycline (doxorubicin) + cyclophosphamide
prostrate CA
docetaxel+prednisone–standard of care–MEN WEAR DOCKERS–DOCETAXEL
mitoxantrone+prednisone–palliation for bone pain
colorectal CA
FOLFOX–folinic acid (leucovorin) +5FU+oxaliplatin–oxes with their stomachs and their poop–good for colon CA
XELOX–XE is the capecitabine–cafecita–coffee makes you poop OX–oxaliplatin–oxes with their poop
Colorectal CA that has metastasized
FOLFIRI: folinic acid (leucovorin) +5FU + Irinotcan–which gives you diarrhea cause of the toucan and fruit loops–so good for colon CA ADD: ziv-aflibercept if progressing
FOLFOX or FOLFIRI+bevacizumab
refractory colon CA
TAS 102–slap TAT ASS
NSCLC standard option
Bevacizumab–take a BEVERAGE since your cup IS NOT SMALL—NON SMALL CELL
Squamous Histo Lung CA
Cisplatin (or carboplatin) + Cetuximab or + gemcitabine +necitumumab
refractory Squamous Cell Lung CA
Nivolumab–finding NIVO–finding NEMO was hard so this is for when the cancer gets really hard
NSCLC maintenance therapy
pemetrexed after 4 cycles of platinum based chemo
NSCLC with L858R exon 19 or 12 mutations that has advanced
Erlotinib–you advance when you’re an Earl of someplace
NSNSCLC with L858R exon 19 or 12 mutations that has metastasized
Afatinib–you’re a fatty now cause of metastasis (I know so wrong)
Small Cell Lung CA
Cisplatin + either etoposide or irinotecan–just remember topoisomerase 2 for etoposide and topoisomerase 1 for irinotecan
Small Cell Lung CA that failed initial therapy
Topotecan
Ovarian CA stage 1
Cisplatin + Cyclophosphamide
Ovarian CA stage 3 and 4
Carboplatin + Paclitaxel
Testicular Cancer
Penises Eat Boobs–Platinum (cisplatin) , Etoposide, Bleomycin
Malignant Melanoma with BRAF V600E whats the most active cytoxic agents?
Dacarbazine or cisplatin
Malignant Melanoma with BRAF V600E what if it is unresectable or metastatic
Nivolumab–remember finding NIMO is so hard–for unresectable CA and Pembrolizumab
Brain Cancer monotherapy what single agent?
Carmustine
Oligodendroglioma regime of choice
PCV–procarbazine + CCNU (lomustine) + vincristine
Adult Glioblastoma–monotherapy or combo therapy
bevacizumab–take a beverage to drink with for your brain B and B
