Chemokines, and Cytokines Flashcards
Source of TNF
Macrophages & T Cells
Target of TNF
Endothelia, epithelia, neutrophils
Function of TNF
Activation (inflammation)
Fever
Source of IL1
Macrophages, endothelial cells
Target of IL1
Endothelia, Hypothalamus, Liver
Function of IL1
Inflammation
Fever (Hypothalamus)
Acute phase protein synthesis
Source of IL6
Macrophages, endothelial cells, T Cells
Target of IL6
Liver, B cells
Function of IL6
Acute phase protein synthesis (Liver)
Proliferation of antibody producing B Cells
Source of IL-12
Dendritic Cells, Macrophages
Target of IL-12
NK cells and T cells
Function of IL-12
Increase INF-G, Th1 Differentiation, increase cytotoxic activity
Source of IL-23
Dendritic Cells, Macrophages
Target of IL-23
T-Cells
Function of IL-23
Promote Th-17 differentiation
Source of IFN-a and IFN-b
Dendritic cells (IFN-a), Fibroblast (IFN-b)
Target of IFN-a and IFN-b
all cells
Function of IFN-a and IFN-b
antiviral immunity, increase MHC-class1, activate NK cells
Source of IFN-g
Th1 cells
Target of IFN-g
T-cells and B-cells
Function of IFN-g
Activate macrophages, isotype switching to IgG
Source of IL4, IL5, IL13
Th2 cells
Target of IL4, IL5, IL13
B cells
Function of IL4, IL5. IL13
Isotype switching to IgE
Source of IL17
Th17 cells
Target of IL17
PMN, epithelia
Function of IL17
activate / mitogen for PMNs, increase antimicrobial peptides
Source of TGF-b
epithelia, NK cells, T-regs, fibroblasts, endothelia
Target of TGF-b
T cells, b-cells
Function of TGF-b
suppress Th1 and Th2 development, promote Th17 differentiation, increase IgA isotype switching
Source IL10
Macrophages, Dendritic cells, Th2
Target of IL10
Macrophages, dendritic cells, T cells
Function of IL10
inhibit IL12 production, reduce MHC class 2 and costimulatory molecule expression
