Chemokines, and Cytokines

Question 1

Source of TNF

Answer 1

Macrophages & T Cells

Question 2

Target of TNF

Answer 2

Endothelia, epithelia, neutrophils

Question 3

Function of TNF

Answer 3

Activation (inflammation)

Fever

Question 4

Source of IL1

Answer 4

Macrophages, endothelial cells

Question 5

Target of IL1

Answer 5

Endothelia, Hypothalamus, Liver

Question 6

Function of IL1

Answer 6

Inflammation
Fever (Hypothalamus)
Acute phase protein synthesis

Question 7

Source of IL6

Answer 7

Macrophages, endothelial cells, T Cells

Question 8

Target of IL6

Answer 8

Liver, B cells

Question 9

Function of IL6

Answer 9

Acute phase protein synthesis (Liver)

Proliferation of antibody producing B Cells

Question 10

Source of IL-12

Answer 10

Dendritic Cells, Macrophages

Question 11

Target of IL-12

Answer 11

NK cells and T cells

Question 12

Function of IL-12

Answer 12

Increase INF-G, Th1 Differentiation, increase cytotoxic activity

Question 13

Source of IL-23

Answer 13

Dendritic Cells, Macrophages

Question 14

Target of IL-23

Answer 14

T-Cells

Question 15

Function of IL-23

Answer 15

Promote Th-17 differentiation

Question 16

Source of IFN-a and IFN-b

Answer 16

Dendritic cells (IFN-a), Fibroblast (IFN-b)

Question 17

Target of IFN-a and IFN-b

Answer 17

all cells

Question 18

Function of IFN-a and IFN-b

Answer 18

antiviral immunity, increase MHC-class1, activate NK cells

Question 19

Source of IFN-g

Answer 19

Th1 cells

Question 20

Target of IFN-g

Answer 20

T-cells and B-cells

Question 21

Function of IFN-g

Answer 21

Activate macrophages, isotype switching to IgG

Question 22

Source of IL4, IL5, IL13

Answer 22

Th2 cells

Question 23

Target of IL4, IL5, IL13

Answer 23

B cells

Question 24

Function of IL4, IL5. IL13

Answer 24

Isotype switching to IgE

Question 25

Source of IL17

Answer 25

Th17 cells

Question 26

Target of IL17

Answer 26

PMN, epithelia

Question 27

Function of IL17

Answer 27

activate / mitogen for PMNs, increase antimicrobial peptides

Question 28

Source of TGF-b

Answer 28

epithelia, NK cells, T-regs, fibroblasts, endothelia

Question 29

Target of TGF-b

Answer 29

T cells, b-cells

Question 30

Function of TGF-b

Answer 30

suppress Th1 and Th2 development, promote Th17 differentiation, increase IgA isotype switching

Question 31

Source IL10

Answer 31

Macrophages, Dendritic cells, Th2

Question 32

Target of IL10

Answer 32

Macrophages, dendritic cells, T cells

Question 33

Function of IL10

Answer 33

inhibit IL12 production, reduce MHC class 2 and costimulatory molecule expression