Chemo tyrosine kinase inhibitor

Question 0

Sprycel

Answer 0

Dasatinib
Maintain clinical activity in CML resistant to imatinib (Gleevec)
The acid for absorption avoid PPI’s and H2 blocker

Question 1

TKIs targeting BCR ABL

Answer 1

ABL1 gene on chromosome 9 translocated to the BCR gene on chromosome 22 resulting in cancer cell growth

1. Gleevec
2. Sprycel
3. Tasigna

Question 2

Gleevec

Answer 2

Imatinib
PO take with food and water
For Philadelphia chromosome positive chronic myelogenous leukemia

Question 3

Tasigna

Answer 3

Nilotinib

Take on empty stomach

Question 4

Zelboraf

Answer 4

Vemurafenib
PO bid
For BRAF positive melanoma

Question 5

Tarceva

Answer 5

Erlotinib targeting EGFR
Take on empty stomach
monitor bilirubin and transaminase

Question 6

Tykerb

Answer 6

Lapatinib (HER-2 neu)
Inhibit ErbB2 and EGFR tyrosine kinase
Take on empty stomach
For metastatic breast cancer in pt who failed trastuzumab and chemotherapy

Question 7

Votrient

Answer 7

Pazopanib inhibits PDGF-R alpha & beta

Take with food do not crush

Question 8

Nexavar

Answer 8

Sorafenib

Question 9

Sutent

Answer 9

Sunitinib

Question 10

Zactima

Answer 10

Vandetanib

Medullary thyroid cancer